1E2HA

The nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by x-ray crystallography
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31
Knot core rangeKnot core lengthKnot tails rangeSlipknot tails rangeSlipknot loops rangeN-end lengthC-end lengthType
view details
+31 5-116 112 1-4 305-329 117-304 4 25 slipknot
Chain Sequence
MPTLLRVYIDGPHGMGKTTTTQLL-----RDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSPPPAL---TLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQCGGSWREDWGQLSGPRPHIGDT---------------LFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGE
sequence length 329
structure length 306
publication title Nucleoside Binding Site of Herpes Simplex Type 1 Thymidine Kinase Analyzed by X-Ray Crystallography
pubmed doi rcsb
molecule tags Transferase
molecule keywords THYMIDINE KINASE
source organism Herpes simplex virus (type 1 / strain 17)
missing residues 25-29, 105-107, 220-234
ec nomenclature ec 2.7.1.21: Thymidine kinase.
pdb deposition date2000-05-23
KnotProt deposition date2014-07-31

pfam database annotations

chain Pfam Accession CodePfam Family IdentifierPfam Description
A PF00693 Herpes_TKThymidine kinase from herpesvirus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolases 1e2hA00
3RDPA 1E2NA 1KI6A 4IVPA 1VTKA 1KI6B 3F0TA 1E2HA 1KI4A 1QHIA 1OF1A 4JBXA 1E2IA 1KI3A 1P75A 2VTKA 1F48A 1E2LA 1KI8A 4IVRA 1E2PA 4JBYA 1E2JA 1KI2A 1P72A 1E2KA 1P7CA 2KI5A 1E2MA 1KI7A 4IVQA 1KIMA 1P6XA 1OSNA 1P73A 3VTKA
chains in the KnotProt database with same CATH superfamily
3RDPA 3M4NA 3FSGA 3L04A 1E2NA 1KI6A 4IVPA 3KZKA 1QMGA 3KZCA 3L02A 2FG7C 1VTKA 4JBXA 3FR8A 2FG6C 2G7MC 1KI6B 3F0TA 1LNSA 1E2HA 1KI4A 1JS1X 3KZMA 3M5DA 3FR7A 1QHIA 1YRLA 1OF1A 3M5CA 3L05A 4IVRA 1E2IA 1KI3A 1P75A 2VTKA 1YH1A 1F48A 1YVEI 1E2LA 1KI8A 3M4JA 2XTJA 1E2PA 4JBYA 2FG7X 1E2JA 1KI2A 1P72A 1E2KA 3KZOA 1P7CA 2KI5A 3L06A 1E2MA 1KI7A 4IVQA 1KIMA 1P6XA 3VTKA 1OSNA 1P73A 3KZNA
chains in the KnotProt database with same CATH topology
3RDPA 1E2NA 1KI6A 4IVPA 1VTKA 1KI6B 3F0TA 1E2HA 1KI4A 1QHIA 1OF1A 4JBXA 1E2IA 1KI3A 1P75A 2VTKA 1F48A 1E2LA 1KI8A 4IVRA 1E2PA 4JBYA 1E2JA 1KI2A 1P72A 1E2KA 1P7CA 2KI5A 1E2MA 1KI7A 4IVQA 1KIMA 1P6XA 1OSNA 1P73A 3VTKA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 3RDP A;  1E2N A;  1KI6 A;  4IVP A;  1VTK A;  1KI6 B;  3F0T A;  1E2H A;  1KI4 A;  1QHI A;  1OF1 A;  4JBX A;  1E2I A;  1KI3 A;  1P75 A;  2VTK A;  1F48 A;  1E2L A;  1KI8 A;  4IVR A;  1E2P A;  4JBY A;  1E2J A;  1KI2 A;  1P72 A;  1E2K A;  1P7C A;  2KI5 A;  1E2M A;  1KI7 A;  4IVQ A;  1KIM A;  1P6X A;  1OSN A;  1P73 A;  3VTK A; 
#chains in the KnotProt database with same CATH topology
 3RDP A;  3M4N A;  3FSG A;  3L04 A;  1E2N A;  1KI6 A;  4IVP A;  3KZK A;  1QMG A;  3KZC A;  3L02 A;  2FG7 C;  1VTK A;  4JBX A;  3FR8 A;  2FG6 C;  2G7M C;  1KI6 B;  3F0T A;  1LNS A;  1E2H A;  1KI4 A;  1JS1 X;  3KZM A;  3M5D A;  3FR7 A;  1QHI A;  1YRL A;  1OF1 A;  3M5C A;  3L05 A;  4IVR A;  1E2I A;  1KI3 A;  1P75 A;  2VTK A;  1YH1 A;  1F48 A;  1YVE I;  1E2L A;  1KI8 A;  3M4J A;  2XTJ A;  1E2P A;  4JBY A;  2FG7 X;  1E2J A;  1KI2 A;  1P72 A;  1E2K A;  3KZO A;  1P7C A;  2KI5 A;  3L06 A;  1E2M A;  1KI7 A;  4IVQ A;  1KIM A;  1P6X A;  3VTK A;  1OSN A;  1P73 A;  3KZN A; 
#chains in the KnotProt database with same CATH homology
 3RDP A;  1E2N A;  1KI6 A;  4IVP A;  1VTK A;  1KI6 B;  3F0T A;  1E2H A;  1KI4 A;  1QHI A;  1OF1 A;  4JBX A;  1E2I A;  1KI3 A;  1P75 A;  2VTK A;  1F48 A;  1E2L A;  1KI8 A;  4IVR A;  1E2P A;  4JBY A;  1E2J A;  1KI2 A;  1P72 A;  1E2K A;  1P7C A;  2KI5 A;  1E2M A;  1KI7 A;  4IVQ A;  1KIM A;  1P6X A;  1OSN A;  1P73 A;  3VTK A; 
1E2KA 4IVQA 1OF1A 4JBYA 1E2HA 1E2IA 4JBXA 1QHIA 4IVPA 4OQLA 3F0TA 2KI5A 4OQMA 1KI2A 1KIMA 1KI8A 1KI7A 1E2NA 4OQNA 1E2MA 1P7CA 1KI3A 4IVRA 1KI4A 4OQXA 1E2LA 1KI6A 1KI6B 1E2PA 1E2JA 2VTKA 1VTKA 3RDPA 3VTKA
similar chains in the KnotProt database (40% sequence similarity)
1E2KB 4IVQB 1OF1B 4JBYB 1E2HB 1E2IB 4JBXB 1QHIB 4IVPB 4OQLB 3F0TB 2KI5B 4OQMB 1KI2B 1KIMB 1KI8B 1KI7B 1E2NB 4OQNB 1E2MB 1P7CB 1KI3B 4IVRB 1KI4B 4OQXB 1E2LB 1E2PB 1E2JB 3RDPB
similar chains in the pdb database (40% sequence similarity)

 
            
               
#similar chains in the KnotProt database (40% sequence similarity)
 1E2K A;  4IVQ A;  1OF1 A;  4JBY A;  1E2H A;  1E2I A;  4JBX A;  1QHI A;  4IVP A;  4OQL A;  3F0T A;  2KI5 A;  4OQM A;  1KI2 A;  1KIM A;  1KI8 A;  1KI7 A;  1E2N A;  4OQN A;  1E2M A;  1P7C A;  1KI3 A;  4IVR A;  1KI4 A;  4OQX A;  1E2L A;  1KI6 A;  1KI6 B;  1E2P A;  1E2J A;  2VTK A;  1VTK A;  3RDP A;  3VTK A; 
               
               
           
#similar chains in the pdb database (40% sequence similarity)
 1E2K B;  4IVQ B;  1OF1 B;  4JBY B;  1E2H B;  1E2I B;  4JBX B;  1QHI B;  4IVP B;  4OQL B;  3F0T B;  2KI5 B;  4OQM B;  1KI2 B;  1KIM B;  1KI8 B;  1KI7 B;  1E2N B;  4OQN B;  1E2M B;  1P7C B;  1KI3 B;  4IVR B;  1KI4 B;  4OQX B;  1E2L B;  1E2P B;  1E2J B;  3RDP B; 
           

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