1QMGA

Acetohydroxyacid isomeroreductase complexed with its reaction product dihydroxy-methylvalerate, manganese and adp-ribose.
Slipknot S 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 271-388 118 1-246, 449-514 247-270, 389-448 246 66 slipknot
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41 237-444 208 1-236, 445-514 236 69 slipknot
Chain Sequence
SATTFDFDSSVFKKEKVTLSGHDEYIVRGGRNLFPLLPDAFKGIKQIGVIGWGSQAPAQAQNLKDSLTEAKSDVVVKIGLRKGSNSFAEARAAGFSEENGTLGDMWETISGSDLVLLLISDSAQADNYEKVFSHMKPNSILGLSHGFLLGHLQSLGQDFPKNISVIAVCPKGMGPSVRRLYVQGKEVNGAGINSSFAVHQDVDGRATDVALGWSIALGSPFTFATTLEQEYKSDIFGERGILLGAVHGIVECLFRRYTESGMSEDLAYKNTVECITGVISKTISTKGMLALYNSLSEEGKKDFQAAYSASYYPSMDILYECYEDVASGSEIRSVVLAGRRFYEKEGLPAFPMGKIDQTRMWKVGEKVRSVRPAGDLGPLYPFTAGVYVALMMAQIEILRKKGHSYSEIINESVIEAVDSLNPFMHARGVSFMVDNCSTTARLGSRKWAPRFDYILSQQALVAVDNGAPINQDLISNFLSDPVHEAIGVCAQLRPSVDISVTADADFVRPELRQA
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 1x 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 270-385 116 1-244, 444-512 245-269, 386-443 244 69 slipknot
41 236-443 208 1-235, 444-512 235 69 knot
Fingerprint Knot forming loop Loop type
K +31 41
Chain closureSer82 <-> Ala595
... Glu319 <->
Bridging ionMn601
<-> Asp315 ... Ser82
probabilistic
Chain Sequence
SATTFDFDSSVFKKEKVTLSGHDEYIVRGGRNLFPLLPDAFKGIKQIGVIGWGSQAPAQAQNLKDSLTEAKSDVVVKIGLRKGSNSFAEARAAGFSEENGTLGDMWETISGSDLVLLLISDSAQADNYEKVFSHMKPNSILGLSHGFLLGHLQSLGQDFPKNISVIAVCPKGMGPSVRRLYVQGKEVNGAGINSSFAVHQDVDGRATDVALGWSIALGSPFTFATTLEQEYKSDIFGERGILLGAVHGIVECLFRRYTESGMSEDLAYKNTVECITGVISKTISTKGMLALYNSLSEEGKKDFQAAYSASYYPSMDILYECYEDVASGSEIRSVVLAGRRFYEKEGLPAFPMGKIDQTRMWKVGEKVRSVRPAGDLGPLYPFTAGVYVALMMAQIEILRKKGHSYSEIINESVIEAVDSLNPFMHARGVSFMVDNCSTTARLGSRKWAPRFDYILSQQALVAVDNGAPINQDLISNFLSDPVHEAIGVCAQLRPSVDISVTADADFVRPELRQA
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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4.1 235-456 222 1-234, 457-514 234 58 knot
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3.2 235-438 204 1-234 457-514 439-456 234 58 slipknot
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3.2 244-460 217 1-234, 490-514 235-243, 461-489 234 25 slipknot
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2.3 247-435 189 1-234, 451-514 235-246, 436-450 234 64 slipknot
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2.3 247-450 204 1-234, 452-514 235-246, 451-451 234 63 slipknot
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2.1 276-413 138 1-243, 436-514 244-275, 414-435 243 79 slipknot
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3.1 276-435 160 1-246, 439-514 247-275, 436-438 246 76 slipknot
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2.1 272-438 167 1-246, 440-514 247-271, 439-439 246 75 slipknot
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2.1 271-439 169 1-247, 441-514 248-270, 440-440 247 74 slipknot
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2.1 271-440 170 1-248, 449-514 249-270, 441-448 248 66 slipknot
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3.1 270-388 119 1-250, 414-514 251-269, 389-413 250 101 slipknot
publication title Structure of Spinach Acetohydroxyacid Isomeroreductase Complexed with its Product of Reaction Dihydroxy-Methylvalerate, Manganese and Adp-Ribose
pubmed doi rcsb
structure length 514
molecule tags Oxidoreductase
source organism Spinacia oleracea
sequence length 514
molecule keywords ACETOHYDROXY-ACID ISOMEROREDUCTASE
ec nomenclature ec 1.1.1.86: Ketol-acid reductoisomerase.
pdb deposition date 1999-09-28
KnotProt deposition date 2018-10-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01450 IlvC Acetohydroxy acid isomeroreductase, catalytic domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1040.10 Mainly Alpha Orthogonal Bundle N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 1qmgA02
3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain 1qmgA01
1.10.1040.10 Mainly Alpha Orthogonal Bundle N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 1qmgA02
3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain 1qmgA01
3FR7A 1YRLA 1R4NB 3FR8A 1QMGA 3ULKA 1YVEI 1R4MB
chains in the KnotProt database with same CATH superfamily
3RDPA 3M4NA 3FSGA 3L04A 1E2NA 1KI6A 4IVPA 3KZKA 1QMGA 3ULKA 1DBIA 1R4MB 3L02A 2FG7C 1VTKA 1GKUB 4JBXA 3FR8A 1II9A 2FG6C 2G7MC 1KI6B 3F0TA 1LNSA 1E2HA 1KI4A 1JS1X 3KZMA 1E2JA 3M5DA 1QHIA 1YRLA 1OF1A 3KZCA 3L05A 4IVRA 1E2IA 1KI3A 1P75A 2VTKA 1YH1A 1F48A 1YVEI 1E2LA 1KI8A 3M4JA 2XTJA 1E2PA 4JBYA 2FG7X 3M5CA 3FR7A 1KI2A 1P72A 1OSNA 3KZOA 1P7CA 2KI5A 3L06A 1E2MA 1KI7A 4IVQA 1R4NB 1KIMA 1P6XA 3VTKA 1E2KA 1P73A 3KZNA
chains in the KnotProt database with same CATH topology
3FR7A 1YRLA 1R4NB 3FR8A 1QMGA 3ULKA 1YVEI 1R4MB
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 3FR7 A;  1YRL A;  1R4N B;  3FR8 A;  1QMG A;  3ULK A;  1YVE I;  1R4M B; 
#chains in the KnotProt database with same CATH topology
 3RDP A;  3M4N A;  3FSG A;  3L04 A;  1E2N A;  1KI6 A;  4IVP A;  3KZK A;  1QMG A;  3ULK A;  1DBI A;  1R4M B;  3L02 A;  2FG7 C;  1VTK A;  1GKU B;  4JBX A;  3FR8 A;  1II9 A;  2FG6 C;  2G7M C;  1KI6 B;  3F0T A;  1LNS A;  1E2H A;  1KI4 A;  1JS1 X;  3KZM A;  1E2J A;  3M5D A;  1QHI A;  1YRL A;  1OF1 A;  3KZC A;  3L05 A;  4IVR A;  1E2I A;  1KI3 A;  1P75 A;  2VTK A;  1YH1 A;  1F48 A;  1YVE I;  1E2L A;  1KI8 A;  3M4J A;  2XTJ A;  1E2P A;  4JBY A;  2FG7 X;  3M5C A;  3FR7 A;  1KI2 A;  1P72 A;  1OSN A;  3KZO A;  1P7C A;  2KI5 A;  3L06 A;  1E2M A;  1KI7 A;  4IVQ A;  1R4N B;  1KIM A;  1P6X A;  3VTK A;  1E2K A;  1P73 A;  3KZN A; 
#chains in the KnotProt database with same CATH homology
 3FR7 A;  1YRL A;  1R4N B;  3FR8 A;  1QMG A;  3ULK A;  1YVE I;  1R4M B; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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