1QMGA

Acetohydroxyacid isomeroreductase complexed with its reaction product dihydroxy-methylvalerate, manganese and adp-ribose.
Genus: 210
Slipknot S 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 271-388 118 1-246, 449-514 247-270, 389-448 246 66 slipknot
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41 237-444 208 1-236, 445-514 236 69 slipknot
Chain Sequence
SATTFDFDSSVFKKEKVTLSGHDEYIVRGGRNLFPLLPDAFKGIKQIGVIGWGSQAPAQAQNLKDSLTEAKSDVVVKIGLRKGSNSFAEARAAGFSEENGTLGDMWETISGSDLVLLLISDSAQADNYEKVFSHMKPNSILGLSHGFLLGHLQSLGQDFPKNISVIAVCPKGMGPSVRRLYVQGKEVNGAGINSSFAVHQDVDGRATDVALGWSIALGSPFTFATTLEQEYKSDIFGERGILLGAVHGIVECLFRRYTESGMSEDLAYKNTVECITGVISKTISTKGMLALYNSLSEEGKKDFQAAYSASYYPSMDILYECYEDVASGSEIRSVVLAGRRFYEKEGLPAFPMGKIDQTRMWKVGEKVRSVRPAGDLGPLYPFTAGVYVALMMAQIEILRKKGHSYSEIINESVIEAVDSLNPFMHARGVSFMVDNCSTTARLGSRKWAPRFDYILSQQALVAVDNGAPINQDLISNFLSDPVHEAIGVCAQLRPSVDISVTADADFVRPELRQA
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 1x 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
41 236-443 208 1-235, 444-512 235 69 knot
+ 31 270-385 116 1-244, 444-512 245-269, 386-443 244 69 slipknot
Fingerprint Knot forming loop Loop type
K 41 +31
Chain closureSer82 <-> Ala595
... Glu319 <->
Bridging ionMn601
<-> Asp315 ... Ser82		 probabilistic
Chain Sequence
SATTFDFDSSVFKKEKVTLSGHDEYIVRGGRNLFPLLPDAFKGIKQIGVIGWGSQAPAQAQNLKDSLTEAKSDVVVKIGLRKGSNSFAEARAAGFSEENGTLGDMWETISGSDLVLLLISDSAQADNYEKVFSHMKPNSILGLSHGFLLGHLQSLGQDFPKNISVIAVCPKGMGPSVRRLYVQGKEVNGAGINSSFAVHQDVDGRATDVALGWSIALGSPFTFATTLEQEYKSDIFGERGILLGAVHGIVECLFRRYTESGMSEDLAYKNTVECITGVISKTISTKGMLALYNSLSEEGKKDFQAAYSASYYPSMDILYECYEDVASGSEIRSVVLAGRRFYEKEGLPAFPMGKIDQTRMWKVGEKVRSVRPAGDLGPLYPFTAGVYVALMMAQIEILRKKGHSYSEIINESVIEAVDSLNPFMHARGVSFMVDNCSTTARLGSRKWAPRFDYILSQQALVAVDNGAPINQDLISNFLSDPVHEAIGVCAQLRPSVDISVTADADFVRPELRQA
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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4.1 235-456 222 1-234, 457-514 234 58 knot
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3.2 235-438 204 1-234 457-514 439-456 234 58 slipknot
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3.2 244-460 217 1-234, 490-514 235-243, 461-489 234 25 slipknot
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2.3 247-435 189 1-234, 451-514 235-246, 436-450 234 64 slipknot
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2.3 247-450 204 1-234, 452-514 235-246, 451-451 234 63 slipknot
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2.1 276-413 138 1-243, 436-514 244-275, 414-435 243 79 slipknot
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3.1 276-435 160 1-246, 439-514 247-275, 436-438 246 76 slipknot
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2.1 272-438 167 1-246, 440-514 247-271, 439-439 246 75 slipknot
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2.1 271-439 169 1-247, 441-514 248-270, 440-440 247 74 slipknot
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2.1 271-440 170 1-248, 449-514 249-270, 441-448 248 66 slipknot
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3.1 270-388 119 1-250, 414-514 251-269, 389-413 250 101 slipknot
sequence length 514
structure length 514
publication title Structure of Spinach Acetohydroxyacid Isomeroreductase Complexed with its Product of Reaction Dihydroxy-Methylvalerate, Manganese and Adp-Ribose
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords ACETOHYDROXY-ACID ISOMEROREDUCTASE
source organism Spinacia oleracea
total genus Genus: 210
ec nomenclature ec 1.1.1.86: Ketol-acid reductoisomerase.
pdb deposition date 1999-09-28
KnotProt deposition date 2018-10-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01450 IlvC Acetohydroxy acid isomeroreductase, catalytic domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1040.10 Mainly Alpha Orthogonal Bundle N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 1qmgA02
3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain 1qmgA01
1.10.1040.10 Mainly Alpha Orthogonal Bundle N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 1qmgA02
3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain 1qmgA01
1YRLA 3ULKA 3FR8A 1QMGA 1R4NB 1R4MB 1YVEI 3FR7A
chains in the KnotProt database with same CATH superfamily
3M4JA 1YRLA 3L05A 3KZNA 3RDPA 2G7MC 3FR8A 1P7CA 4IVQA 1E2KA 4JBYA 1E2JA 1KI6A 1QHIA 1VTKA 1KI4A 1P6XA 3M5CA 3KZMA 1F48A 2FG6C 3M4NA 3KZCA 1KIMA 1E2NA 1KI6B 1DBIA 1R4NB 2KI5A 3L02A 1OSNA 1LNSA 1OF1A 1YVEI 3L06A 1E2MA 1YH1A 1JS1X 3FSGA 1II9A 1P75A 1KI2A 1R4MB 1E2LA 3FR7A 1KI7A 4JBXA 1KI8A 3VTKA 4IVRA 3F0TA 3KZKA 3ULKA 1QMGA 1E2PA 1E2HA 1KI3A 3KZOA 2XTJA 3M5DA 4IVPA 1P73A 1GKUB 1P72A 1E2IA 2VTKA 3L04A
chains in the KnotProt database with same CATH topology
1YRLA 3ULKA 3FR8A 1QMGA 1R4NB 1R4MB 1YVEI 3FR7A
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1YRL A;  3ULK A;  3FR8 A;  1QMG A;  1R4N B;  1R4M B;  1YVE I;  3FR7 A; 
#chains in the KnotProt database with same CATH topology
 3M4J A;  1YRL A;  3L05 A;  3KZN A;  3RDP A;  2G7M C;  3FR8 A;  1P7C A;  4IVQ A;  1E2K A;  4JBY A;  1E2J A;  1KI6 A;  1QHI A;  1VTK A;  1KI4 A;  1P6X A;  3M5C A;  3KZM A;  1F48 A;  2FG6 C;  3M4N A;  3KZC A;  1KIM A;  1E2N A;  1KI6 B;  1DBI A;  1R4N B;  2KI5 A;  3L02 A;  1OSN A;  1LNS A;  1OF1 A;  1YVE I;  3L06 A;  1E2M A;  1YH1 A;  1JS1 X;  3FSG A;  1II9 A;  1P75 A;  1KI2 A;  1R4M B;  1E2L A;  3FR7 A;  1KI7 A;  4JBX A;  1KI8 A;  3VTK A;  4IVR A;  3F0T A;  3KZK A;  3ULK A;  1QMG A;  1E2P A;  1E2H A;  1KI3 A;  3KZO A;  2XTJ A;  3M5D A;  4IVP A;  1P73 A;  1GKU B;  1P72 A;  1E2I A;  2VTK A;  3L04 A; 
#chains in the KnotProt database with same CATH homology
 1YRL A;  3ULK A;  3FR8 A;  1QMG A;  1R4N B;  1R4M B;  1YVE I;  3FR7 A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling