1XJDA

Crystal structure of pkc-theta complexed with staurosporine at 2a resolution
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S -31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
-31 127-311 185 312-320 1-110 111-126 110 8 slipknot
Chain Sequence
IEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDP--------------------------------------QNMFRNFSF
sequence length 320
structure length 282
publication title Catalytic domain crystal structure of protein kinase C-theta (PKCtheta)
pubmed doi rcsb
molecule tags Transferase
molecule keywords Protein kinase C, theta type
source organism Homo sapiens
missing residues 274-311
ec nomenclature ec 2.7.11.13: Protein kinase C.
pdb deposition date 2004-09-23
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00433 Pkinase_C Protein kinase C terminal domain
Image from the rcsb pdb (www.rcsb.org)
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5



Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1m 121-273 153 274-282 1-105 106-120 105 8 slipknot
cath code
ClassArchitectureTopologyHomologyDomain
1.10.510.10 Mainly Alpha Orthogonal Bundle Transferase(Phosphotransferase); domain 1 Transferase(Phosphotransferase) domain 1 1xjdA02
3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase; domain 1 Phosphorylase Kinase; domain 1 1xjdA01
1XJDA
chains in the KnotProt database with same CATH superfamily
1XJDA
chains in the KnotProt database with same CATH topology
1XJDA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1XJD A; 
#chains in the KnotProt database with same CATH topology
 1XJD A; 
#chains in the KnotProt database with same CATH homology
 1XJD A; 
3UBDA 4EL9A 4GUEA 1XJDA 5N3JA 5N1FA 5N1GA 5N3SA 5N3IA 5N3GA 5N1HA 4WIHA 5N3TA 5N3NA 5N3MA 1RDQE 5N3QA 5N3OA 5N3KA 5N3LA 5N3HA 4DFXE 5N3RA 5N7UA 5LCPA 5LCQA 5N1NA 5N3AA 5N33A 5N1MA 5N39A 5O0EA 5N1LA 5MHIA 5N7PA 5N1EA 5NTJA 5N3EA 4GV1A 5N37A 5N36A 5LCRA 4WB8A 5LCUA 4C38A 5LCTA 5N3PA 4IAIA 4HPUE 5N1DA 3OVVA 3FJQE 4WB5A 1XH9A 5VHBA 5N3BA 4IAKA 3POOA 3ZO4A 4Z84A 4C37A 4C33A 3X2WA 1XH8A 5N3FA 4IB1A 3QALE 3IDBA 4NW6A 4O22A 4UJ1A 5N3DA 5N3CA 5N1OA 1O6KA 4C34A 3X2VA 5N1KA 2JDOA 4DH7A 3AMAA 4Z83E 4DG3E 5LI9A 4UJ9A 4XW4A 3WF7A 3OWPA 3OW3A 5BX6A 4UJBA 5N32A 1Q8UA 3KKVA 4UJAA 4OTHA 5BX7A 2VO0A 1VZOA 3ZO2A 4C36A 5LI1A 4O21A 5IZJA 4IE9A 2GFCA 4XW6A 4NW5A 3G51A 4IAZA 3ZO1A 2C1BA 4IADA 2C1AA 2GNGA 1XH6A 2R5TA 2VO6A 4OTIA 3QKLA 4UJ2A 4XW5A 3QAME 2UVXA 4EKLA 3WE4A 4OTDA 3P0MA 3VQHA 3DNEA 4IAYA 1Q8TA 3MVHA 2VO3A 4IB0A 2VO7A 1APME 1SVGA 2UW8A 2UVZA 4AXAA 4DG2E 4DG0E 3L9MA 3WF8A 1XH5A 1CDKA 4DH1A 3FHIA 5NW8A 3ZO3A 2VNWA 3WF5A 1SMHA 5D9LA 3CQWA 3AG9A 2UW0A 1L3RE 4YXSA 2UVYA 4IAFA 3WF6A 4DFZE 1Q61A 3D0EA 3TXOA 2GNHA 2JDSA 5N23A 4WB6A 4WB6B 4IACA 2VNYA 3L9NA 3OOGA 3L9LA 2UW4A 3NX8A 4DH8A 1JBPE 1RE8A 3OXTA 1ATPE 3AGLA 4HPTE 3AGMA 3A8XA 3WF9A 4IB3A 1FMOE 4C35A 2JDVA 4L3LA 4DH5A 1YDRE 1BX6A 2UW3A 4L3JA 1JLUE 3QKMA 2JDTA 2QCSA 2UW5A 2F7XE 4AE6A 2UW6A 1YDSE 3E8EA 4DH3A 2GNJA 3DNDA 2GU8A 2GNIA 4YXRA 3CQUA 1REJA 2Z7RA 5IZFA 5UZKA 2JEDA 1Q62A 4DC2A 1YDTE 2GNFA 2UW7A 2Z7QA 1Q8WA 4AE9A 3BWJA 3QKKA 4X6RA 3AMBA 2ERZE 4NUSA 1STCE 3A8WA 6CCYA 1SVHA 2F7EE 1XH4A 1REKA 4IJ9A 3X2UA 1XH7A 2OJFE 5D9KA 3E87A 3TNPC 2UZTA 4RLOA 3MV5A 1SVEA 2Z7SA 3A62A 4X6QC 4RA4A 2CPKE 3E8CA 2QVSE 2QURA 3OW4A 1GZKA 3MVJA 1XHAA 1Q24A 2GNLA 2OH0E 4OTGA 3E88A 1SZMA 1BKXA 4Q9ZA 4Q9ZB 3HDMA 1FOTA 3IW4A 1VEBA 1SYKA 1CTPE 3OCBA 4RA5A 3ZH8A 4CRSA 4RLPA 2UZVA 2I0EA 3A60A 5J5XA 2UZWE 3O7LB 3O7LD 4EKKA 1GZNA 1MRYA 3IDCA 4L42A 4WBBB 1GZOA 4L46A 1CMKE 1MRVA 4L45A 5X3FB 4L43A 4L44A 2UZUE 4NTSA 3TNQB 1J3HA 2F7ZE 1ZRZA 4DFYA 3HDNA 3PVBA 4DINA 4NTTA 5LIHA 3A61A 5JR7A 3J4QD 3J4RD
similar chains in the KnotProt database (40% sequence similarity)
5M6YA 5M6VA 5M0BA 5M0LA 5M71A 5M75A 5O5MA 5M0UA 1O6LA 5M0CA 2X39A 5IZJB 5VI9A 3L9MB 1CDKB 5F9EA 5F9EB 3AG9B 3D0EB 3L9LB 3AGLB 3A8XB 4AE6B 3E8EB 3E8EE 3E8EI 3E8EL 3E8EP 2UW9A 2JEDB 2JDRA 4AE9B 3A8WB 5D9KB 3E87B 3TNPF 5VIBA 4RLOB 3E8CB 3E8CC 3E8CD 3E8CE 3E8CF 3OW4B 3MVJB 3MVJE 3E88B 6C0UA 1SZMB 3IW4B 3IW4C 3E8DA 3E8DB 1SYKB 3OCBB 4RA5B 3ZH8B 3ZH8C 2XH5A 2I0EB 3A60B 4EKKB 4NTSB 1J3HB 4DFYE 4NTTB 5LIHB 5JR7C 3J4QE 3J4RE
similar chains in the pdb database (40% sequence similarity)

 
            
               
#similar chains in the KnotProt database (40% sequence similarity)
 3UBD A;  4EL9 A;  4GUE A;  1XJD A; 
               
               
#similar chains, but unknotted
 5N3J A;  5N1F A;  5N1G A;  5N3S A;  5N3I A;  5N3G A;  5N1H A;  4WIH A;  5N3T A;  5N3N A;  5N3M A;  1RDQ E;  5N3Q A;  5N3O A;  5N3K A;  5N3L A;  5N3H A;  4DFX E;  5N3R A;  5N7U A;  5LCP A;  5LCQ A;  5N1N A;  5N3A A;  5N33 A;  5N1M A;  5N39 A;  5O0E A;  5N1L A;  5MHI A;  5N7P A;  5N1E A;  5NTJ A;  5N3E A;  4GV1 A;  5N37 A;  5N36 A;  5LCR A;  4WB8 A;  5LCU A;  4C38 A;  5LCT A;  5N3P A;  4IAI A;  4HPU E;  5N1D A;  3OVV A;  3FJQ E;  4WB5 A;  1XH9 A;  5VHB A;  5N3B A;  4IAK A;  3POO A;  3ZO4 A;  4Z84 A;  4C37 A;  4C33 A;  3X2W A;  1XH8 A;  5N3F A;  4IB1 A;  3QAL E;  3IDB A;  4NW6 A;  4O22 A;  4UJ1 A;  5N3D A;  5N3C A;  5N1O A;  1O6K A;  4C34 A;  3X2V A;  5N1K A;  2JDO A;  4DH7 A;  3AMA A;  4Z83 E;  4DG3 E;  5LI9 A;  4UJ9 A;  4XW4 A;  3WF7 A;  3OWP A;  3OW3 A;  5BX6 A;  4UJB A;  5N32 A;  1Q8U A;  3KKV A;  4UJA A;  4OTH A;  5BX7 A;  2VO0 A;  1VZO A;  3ZO2 A;  4C36 A;  5LI1 A;  4O21 A;  5IZJ A;  4IE9 A;  2GFC A;  4XW6 A;  4NW5 A;  3G51 A;  4IAZ A;  3ZO1 A;  2C1B A;  4IAD A;  2C1A A;  2GNG A;  1XH6 A;  2R5T A;  2VO6 A;  4OTI A;  3QKL A;  4UJ2 A;  4XW5 A;  3QAM E;  2UVX A;  4EKL A;  3WE4 A;  4OTD A;  3P0M A;  3VQH A;  3DNE A;  4IAY A;  1Q8T A;  3MVH A;  2VO3 A;  4IB0 A;  2VO7 A;  1APM E;  1SVG A;  2UW8 A;  2UVZ A;  4AXA A;  4DG2 E;  4DG0 E;  3L9M A;  3WF8 A;  1XH5 A;  1CDK A;  4DH1 A;  3FHI A;  5NW8 A;  3ZO3 A;  2VNW A;  3WF5 A;  1SMH A;  5D9L A;  3CQW A;  3AG9 A;  2UW0 A;  1L3R E;  4YXS A;  2UVY A;  4IAF A;  3WF6 A;  4DFZ E;  1Q61 A;  3D0E A;  3TXO A;  2GNH A;  2JDS A;  5N23 A;  4WB6 A;  4WB6 B;  4IAC A;  2VNY A;  3L9N A;  3OOG A;  3L9L A;  2UW4 A;  3NX8 A;  4DH8 A;  1JBP E;  1RE8 A;  3OXT A;  1ATP E;  3AGL A;  4HPT E;  3AGM A;  3A8X A;  3WF9 A;  4IB3 A;  1FMO E;  4C35 A;  2JDV A;  4L3L A;  4DH5 A;  1YDR E;  1BX6 A;  2UW3 A;  4L3J A;  1JLU E;  3QKM A;  2JDT A;  2QCS A;  2UW5 A;  2F7X E;  4AE6 A;  2UW6 A;  1YDS E;  3E8E A;  4DH3 A;  2GNJ A;  3DND A;  2GU8 A;  2GNI A;  4YXR A;  3CQU A;  1REJ A;  2Z7R A;  5IZF A;  5UZK A;  2JED A;  1Q62 A;  4DC2 A;  1YDT E;  2GNF A;  2UW7 A;  2Z7Q A;  1Q8W A;  4AE9 A;  3BWJ A;  3QKK A;  4X6R A;  3AMB A;  2ERZ E;  4NUS A;  1STC E;  3A8W A;  6CCY A;  1SVH A;  2F7E E;  1XH4 A;  1REK A;  4IJ9 A;  3X2U A;  1XH7 A;  2OJF E;  5D9K A;  3E87 A;  3TNP C;  2UZT A;  4RLO A;  3MV5 A;  1SVE A;  2Z7S A;  3A62 A;  4X6Q C;  4RA4 A;  2CPK E;  3E8C A;  2QVS E;  2QUR A;  3OW4 A;  1GZK A;  3MVJ A;  1XHA A;  1Q24 A;  2GNL A;  2OH0 E;  4OTG A;  3E88 A;  1SZM A;  1BKX A;  4Q9Z A;  4Q9Z B;  3HDM A;  1FOT A;  3IW4 A;  1VEB A;  1SYK A;  1CTP E;  3OCB A;  4RA5 A;  3ZH8 A;  4CRS A;  4RLP A;  2UZV A;  2I0E A;  3A60 A;  5J5X A;  2UZW E;  3O7L B;  3O7L D;  4EKK A;  1GZN A;  1MRY A;  3IDC A;  4L42 A;  4WBB B;  1GZO A;  4L46 A;  1CMK E;  1MRV A;  4L45 A;  5X3F B;  4L43 A;  4L44 A;  2UZU E;  4NTS A;  3TNQ B;  1J3H A;  2F7Z E;  1ZRZ A;  4DFY A;  3HDN A;  3PVB A;  4DIN A;  4NTT A;  5LIH A;  3A61 A;  5JR7 A;  3J4Q D;  3J4R D;                               
               
           
#similar chains in the pdb database (40% sequence similarity)
 5M6Y A;  5M6V A;  5M0B A;  5M0L A;  5M71 A;  5M75 A;  5O5M A;  5M0U A;  1O6L A;  5M0C A;  2X39 A;  5IZJ B;  5VI9 A;  3L9M B;  1CDK B;  5F9E A;  5F9E B;  3AG9 B;  3D0E B;  3L9L B;  3AGL B;  3A8X B;  4AE6 B;  3E8E B;  3E8E E;  3E8E I;  3E8E L;  3E8E P;  2UW9 A;  2JED B;  2JDR A;  4AE9 B;  3A8W B;  5D9K B;  3E87 B;  3TNP F;  5VIB A;  4RLO B;  3E8C B;  3E8C C;  3E8C D;  3E8C E;  3E8C F;  3OW4 B;  3MVJ B;  3MVJ E;  3E88 B;  6C0U A;  1SZM B;  3IW4 B;  3IW4 C;  3E8D A;  3E8D B;  1SYK B;  3OCB B;  4RA5 B;  3ZH8 B;  3ZH8 C;  2XH5 A;  2I0E B;  3A60 B;  4EKK B;  4NTS B;  1J3H B;  4DFY E;  4NTT B;  5LIH B;  5JR7 C;  3J4Q E;  3J4R E; 
           

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