2XR9A

Crystal structure of autotaxin (enpp2)
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 115-253 139 1-114 432-804 254-431 114 373 slipknot
Chain Sequence
GSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIKVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDASFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKSI----YDPKTIIAALTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPCFFQ----------GDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPDEVSRPNYPGIMYLQSEFDLGCTCDKLEELNKRLHTKGS-------TKERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWAYFQRVLVKKYASERNGVNVISGPIFDYNYDGLRDTEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYE
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5



Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 43-301 259 1-42 308-783 302-307 42 476 slipknot
view details
3.1 114-304 191 1-113 416-783 305-415 113 368 slipknot
view details
2.1 62-415 354 1-11, 420-783 12-61, 416-419 11 364 slipknot
sequence length 804
structure length 783
publication title Structural Basis of Substrate Discrimination and Integrin Binding by Autotaxin.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2
source organism Rattus norvegicus
missing residues 343-346, 403-412, 515-521
ec nomenclature ec 3.1.4.39: Alkylglycerophosphoethanolamine phosphodiesterase.
pdb deposition date 2010-09-13
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01663 Phosphodiest Type I phosphodiesterase / nucleotide pyrophosphatase
Image from the rcsb pdb (www.rcsb.org)
5OHIA 4ZG7A 3NKQA 3NKRA 3WAYA 3NKOA 3NKPA 5OLBA 3NKNA 3WAVA 5DLWA 3WAXA 3NKMA 4ZG6A 5IJQA 3WAWA 2XR9A 5DLVA 5IJSA 5M0SA 4GTWA 4B56A 2XRGA 4GTXA 4GTZA 4GTYA
similar chains in the KnotProt database (40% sequence similarity)
5DLTA 5INHA 5LIAA 6C02A 6C02B 5HRTA 4ZG6B 5M0EA 5DLVB 5GZ5A 5M0MA 6C01A 6C01B 5L0BA 5L0BB 5KXAA 5MHPA 5LQQA 5M0DA 4ZGAA 4ZG9A 4ZG9B 5GZ4A 5L0EA 5L0EB 5L0KA 5L0KB 5M7MA 4GTWB 4B56B 4GTXB 4GTZB 4GTYB
similar chains in the pdb database (40% sequence similarity)

 
            
               
#similar chains in the KnotProt database (40% sequence similarity)
 5OHI A;  4ZG7 A;  3NKQ A;  3NKR A;  3WAY A;  3NKO A;  3NKP A;  5OLB A;  3NKN A;  3WAV A;  5DLW A;  3WAX A;  3NKM A;  4ZG6 A;  5IJQ A;  3WAW A;  2XR9 A;  5DLV A;  5IJS A;  5M0S A;  4GTW A;  4B56 A;  2XRG A;  4GTX A;  4GTZ A;  4GTY A; 
               
               
           
#similar chains in the pdb database (40% sequence similarity)
 5DLT A;  5INH A;  5LIA A;  6C02 A;  6C02 B;  5HRT A;  4ZG6 B;  5M0E A;  5DLV B;  5GZ5 A;  5M0M A;  6C01 A;  6C01 B;  5L0B A;  5L0B B;  5KXA A;  5MHP A;  5LQQ A;  5M0D A;  4ZGA A;  4ZG9 A;  4ZG9 B;  5GZ4 A;  5L0E A;  5L0E B;  5L0K A;  5L0K B;  5M7M A;  4GTW B;  4B56 B;  4GTX B;  4GTZ B;  4GTY B; 
           

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