2WXZC

Crystal structure of rat angiotensinogen in c2 space group
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 278-421 144 1-252, 432-445 253-277, 422-431 252 14 slipknot
Chain Sequence
HPFHLLYYSKSTCAQ-------TLPEPTFEPVPIQAKTSPVDEKTLRDKLVLATEKLEAEDRQRAAQVAMIANFMGFRMYKMLSEARVASGAVL-SPPALFGTLVSFYLGSLDPTASQLQVLLGVPVKEGDCTSRLDGHKVLTALQAVQGLLVTPLLQSTVV--------GLFTAPGLRLKQPFVESLGPFTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDSTLFFNTYVHFQGKMRGFSQLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNNFSVTRVPLGESVTLLLIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQAKLSTLLGAEANLGKMGDTNPRVGEVLNSILLELQAGVLDVTLSSPFLFAIYE----------------RDSGALHFLGRVDNPQ
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5



Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
sequence length 445
structure length 413
publication title A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
pubmed doi rcsb
molecule tags Hormone
molecule keywords ANGIOTENSINOGEN
source organism Rattus norvegicus
missing residues 16-22, 88, 155-162, 398-413
ec nomenclature
pdb deposition date 2009-11-11
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2wxzC01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2wxzC02
2WXZC 1BY7A 3NDAA
chains in the KnotProt database with same CATH superfamily
2WXZC 1BY7A 3NDAA
chains in the KnotProt database with same CATH topology
2WXZC 1BY7A 3NDAA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 2WXZ C;  1BY7 A;  3NDA A; 
#chains in the KnotProt database with same CATH topology
 2WXZ C;  1BY7 A;  3NDA A; 
#chains in the KnotProt database with same CATH homology
 2WXZ C;  1BY7 A;  3NDA A; 
2WXZC 5M3YA 2WXYC 2WY0C 5M3XA 2WXXA 2WXZA 2WY1A 2WXWA 2X0BB
similar chains in the KnotProt database (40% sequence similarity)
5M3XB 2WXXB 2WXXC 2WXXD 2WY1B 2X0BD 2X0BF 2X0BH
similar chains in the pdb database (40% sequence similarity)

 
            
               
#similar chains in the KnotProt database (40% sequence similarity)
 2WXZ C; 
               
               
#similar chains, but unknotted
 5M3Y A;  2WXY C;  2WY0 C;  5M3X A;  2WXX A;  2WXZ A;  2WY1 A;  2WXW A;  2X0B B;                               
               
           
#similar chains in the pdb database (40% sequence similarity)
 5M3X B;  2WXX B;  2WXX C;  2WXX D;  2WY1 B;  2X0B D;  2X0B F;  2X0B H; 
           

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