3FR7A

Ketol-acid reductoisomerase (kari) in complex with mg2+
Knot K 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 265-381 117 1-241, 438-493 242-264, 382-437 241 56 slipknot
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41 232-438 207 1-231, 439-493 231 55 knot
Chain Sequence
LDFDTSVFNKEKVSLAGHEEYIVRGGRNLFPLLPEAFKGIKQIGVIGWGSQGPAQAQNLRDSLAEAKSDIVVKIGLRKGSKSFDEARAAGFTEESGTLGDIWETVSGSDLVLLLISDAAQADNYEKIFSHMKPNSILGLSHGFLLGHLQSAGLDFPKNISVIAVCPKGMGPSVRRLYVQGKEINGAGINSSFAVHQDVDGRATDVALGWSVALGSPFTFATTLEQEYKSDIFGERGILLGAVHGIVEALFRRYTEQGMDEEMAYKNTVEGITGIISKTISKKGMLEVYNSLTEEGKKEFNKAYSASFYPCMDILYECYEDVASGSEIRSVVLAGRRFYEKEGLPAFPMGNIDQTRMWKVGEKVRSTRPENDLGPLHPFTAGVYVALMMAQIEVLRKKGHSYSEIINESVIESVDSLNPFMHARGVAFMVDNCSTTARLGSRKWAPRFDYILTQQAFVTVDKDAPINQDLISNFMSDPVHGAIEVCAELRPTVDIS
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 2x 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 268-384 117 1-243, 438-495 244-267, 385-437 243 58 slipknot
41 234-439 206 1-233, 440-495 233 56 knot
Fingerprint Knot forming loop Loop type
K +31 41 Leu86 ... Ser580 probabilistic
K +31 41 Leu86 ... Asp315 <->
Bridging ionMg1576
<-> Glu319 ...
Chain closureSer580 <-> Leu86
probabilistic
Chain Sequence
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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4.1 229-446 218 1-228, 447-495 228 49 knot
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3.2 171-432 262 1-170 452-495 433-451 170 44 slipknot
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4.1 230-449 220 1-228, 489-495 229-229, 450-488 228 7 slipknot
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4.1 231-453 223 1-229, 494-495 230-230, 454-493 229 2 slipknot
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3.2 241-456 216 1-230, 485-495 231-240, 457-484 230 11 slipknot
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3.2 242-461 220 1-240, 484-495 241-241, 462-483 240 12 slipknot
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3.2 242-484 243 1-230, 495-495 231-241, 485-494 230 1 slipknot
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2.1 253-386 134 1-237, 409-495 238-252, 387-408 237 87 slipknot
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3.1 261-389 129 1-248, 413-495 249-260, 390-412 248 83 slipknot
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3.1 266-389 124 1-260, 413-495 261-265, 390-412 260 83 slipknot
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2.1 267-409 143 1-250, 432-495 251-266, 410-431 250 64 slipknot
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2.1 268-431 164 1-251, 448-495 252-267, 432-447 251 48 slipknot
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3.1 268-410 143 1-266, 432-495 267-267, 411-431 266 64 slipknot
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2.1 272-409 138 1-267, 432-495 268-271, 410-431 267 64 slipknot
publication title Conformational changes in a plant ketol-acid reductoisomerase upon Mg(2+) and NADPH binding as revealed by two crystal structures
pubmed doi rcsb
structure length 495
molecule tags Oxidoreductase
source organism Oryza sativa japonica group
sequence length 495
molecule keywords Putative ketol-acid reductoisomerase (Os05g0573700 protein)
ec nomenclature ec 1.1.1.86: Ketol-acid reductoisomerase.
pdb deposition date 2009-01-08
KnotProt deposition date 2018-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01450 IlvC Acetohydroxy acid isomeroreductase, catalytic domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1040.10 Mainly Alpha Orthogonal Bundle N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 3fr7A02
3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain 3fr7A01
1.10.1040.10 Mainly Alpha Orthogonal Bundle N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 3fr7A02
3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain 3fr7A01
3FR7A 1YRLA 1R4NB 3FR8A 1QMGA 3ULKA 1YVEI 1R4MB
chains in the KnotProt database with same CATH superfamily
3RDPA 3M4NA 3FSGA 3L04A 1E2NA 1KI6A 4IVPA 3KZKA 1QMGA 3ULKA 1DBIA 1R4MB 3L02A 2FG7C 1VTKA 1GKUB 4JBXA 3FR8A 2FG6C 2G7MC 1KI6B 3F0TA 1LNSA 1E2HA 1KI4A 1JS1X 3KZMA 1E2JA 3M5DA 1QHIA 1YRLA 1OF1A 3KZCA 3L05A 4IVRA 1E2IA 1KI3A 1P75A 2VTKA 1YH1A 1F48A 1YVEI 1E2LA 1KI8A 3M4JA 2XTJA 1E2PA 4JBYA 2FG7X 3M5CA 3FR7A 1KI2A 1P72A 1OSNA 3KZOA 1P7CA 2KI5A 3L06A 1E2MA 1KI7A 4IVQA 1R4NB 1KIMA 1P6XA 3VTKA 1E2KA 1P73A 3KZNA
chains in the KnotProt database with same CATH topology
3FR7A 1YRLA 1R4NB 3FR8A 1QMGA 3ULKA 1YVEI 1R4MB
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 3FR7 A;  1YRL A;  1R4N B;  3FR8 A;  1QMG A;  3ULK A;  1YVE I;  1R4M B; 
#chains in the KnotProt database with same CATH topology
 3RDP A;  3M4N A;  3FSG A;  3L04 A;  1E2N A;  1KI6 A;  4IVP A;  3KZK A;  1QMG A;  3ULK A;  1DBI A;  1R4M B;  3L02 A;  2FG7 C;  1VTK A;  1GKU B;  4JBX A;  3FR8 A;  2FG6 C;  2G7M C;  1KI6 B;  3F0T A;  1LNS A;  1E2H A;  1KI4 A;  1JS1 X;  3KZM A;  1E2J A;  3M5D A;  1QHI A;  1YRL A;  1OF1 A;  3KZC A;  3L05 A;  4IVR A;  1E2I A;  1KI3 A;  1P75 A;  2VTK A;  1YH1 A;  1F48 A;  1YVE I;  1E2L A;  1KI8 A;  3M4J A;  2XTJ A;  1E2P A;  4JBY A;  2FG7 X;  3M5C A;  3FR7 A;  1KI2 A;  1P72 A;  1OSN A;  3KZO A;  1P7C A;  2KI5 A;  3L06 A;  1E2M A;  1KI7 A;  4IVQ A;  1R4N B;  1KIM A;  1P6X A;  3VTK A;  1E2K A;  1P73 A;  3KZN A; 
#chains in the KnotProt database with same CATH homology
 3FR7 A;  1YRL A;  1R4N B;  3FR8 A;  1QMG A;  3ULK A;  1YVE I;  1R4M B; 
3FR7A 3FR8A 1QMGA 1YVEI
similar chains in the KnotProt database (40% sequence similarity)
3FR7B 1QMGB 1QMGC 1QMGD 1YVEJ 1YVEK 1YVEL 3FR8B
similar chains in the pdb database (40% sequence similarity)

 
            
               
#similar chains in the KnotProt database (40% sequence similarity)
 3FR7 A;  3FR8 A; 
               
               
#similar chains, but unknotted
 1QMG A;  1YVE I;                               
               
           
#similar chains in the pdb database (40% sequence similarity)
 3FR7 B;  1QMG B;  1QMG C;  1QMG D;  1YVE J;  1YVE K;  1YVE L;  3FR8 B; 
           

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