3RG3A

Crystal structure of the w5e mutant of human carbonic anhydrase ii
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 21-252 232 253-256 1-1 2-20 1 3 slipknot
Chain Sequence
GYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 3x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 25-252 228 1-24, 253-256 24 4 knot
Fingerprint Knot forming loop Loop type
K +31 Gly6 ... His94 <->
Bridging ionZn262
<-> His96 ...
Chain closureLys261 <-> Gly6
probabilistic
K +31
Chain closureGly6 <-> Lys261
... His119 <->
Bridging ionZn262
<-> His96 ... Gly6
probabilistic
K +31 Gly6 ... His94 <->
Bridging ionZn262
<-> His119 ...
Chain closureLys261 <-> Gly6
probabilistic
Chain Sequence
GYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 24-253 230 1-23, 254-255 23 2 knot
view details
2.1 22-249 228 1-21 255-255 250-254 21 1 slipknot
publication title Structure and catalysis by carbonic anhydrase II: role of active-site tryptophan 5.
pubmed doi rcsb
structure length 255
molecule tags Lyase
source organism Homo sapiens
sequence length 255
molecule keywords Carbonic anhydrase 2
ec nomenclature ec 4.2.1.1: Carbonate dehydratase.
pdb deposition date 2011-04-07
KnotProt deposition date 2018-10-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00194 Carb_anhydrase Eukaryotic-type carbonic anhydrase
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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