3ZP9A

Human carbonic anhydrase ii as a scaffold for an artificial transfer hydrogenase
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 23-255 233 256-259 1-1 2-22 1 3 slipknot
Chain Sequence
HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 7x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 25-255 231 1-24, 256-259 24 4 knot
Fingerprint Knot forming loop Loop type
K +31 His3 ... His94 <->
Bridging ionZn1009
<-> His96 ...
Chain closureLys261 <-> His3
probabilistic
K +31
Chain closureHis3 <-> Lys261
... Glu205 <->
Bridging ionMbo1006
<-> Gln137 ... His3
probabilistic
K +31 His3 ... His96 <->
Bridging ionZn1009
<-> His119 ...
Chain closureLys261 <-> His3
probabilistic
K +31 His3 ... His94 <->
Bridging ionZn1009
<-> His119 ...
Chain closureLys261 <-> His3
probabilistic
K +31
Chain closureHis3 <-> Lys261
... Glu205 <->
Bridging ionMbo1006
<-> Gln137 ... His96 <->
Bridging ionZn1009
<-> His94 ... His3
probabilistic
K +31
Chain closureHis3 <-> Lys261
... Glu205 <->
Bridging ionMbo1006
<-> Gln137 ... His119 <->
Bridging ionZn1009
<-> His96 ... His3
probabilistic
K +31
Chain closureHis3 <-> Lys261
... Glu205 <->
Bridging ionMbo1006
<-> Gln137 ... His119 <->
Bridging ionZn1009
<-> His94 ... His3
probabilistic
Chain Sequence
HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 25-257 233 1-24, 258-258 24 1 knot
view details
2.1 26-252 227 1-25 258-258 253-257 25 1 slipknot
publication title Human Carbonic Anhydrase II as Host Protein for the Creation of Artificial Metalloenzymes: The Asymmetric Transfer Hydrogenation of Imines
doi rcsb
structure length 258
molecule tags Lyase
source organism Homo sapiens
sequence length 258
molecule keywords CARBONIC ANHYDRASE 2
ec nomenclature ec 4.2.1.1: Carbonate dehydratase.
pdb deposition date 2013-02-27
KnotProt deposition date 2018-10-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00194 Carb_anhydrase Eukaryotic-type carbonic anhydrase
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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