3BDGA

Crystal structure of wild-type/t155v mixed dimer of e. coli alkaline phosphatase
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 159
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 46-367 322 1-45 418-448 368-417 45 31 slipknot
Chain Sequence
PEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDAVPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASI------ANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGHTGSQL--------RIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 46-365 320 1-45 396-434 366-395 45 39 slipknot
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3.1 46-395 350 1-45 402-434 396-401 45 33 slipknot
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2.1 44-401 358 1-43 406-434 402-405 43 29 slipknot
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2.1 37-405 369 1-5, 407-434 6-36, 406-406 5 28 slipknot
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2.1 31-359 329 1-7, 366-434 8-30, 360-365 7 69 slipknot
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2.1 38-360 323 1-30, 366-434 31-37, 361-365 30 69 slipknot
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2.1 39-361 323 1-37, 366-434 38-38, 362-365 37 69 slipknot
sequence length 448
structure length 434
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
source organism Escherichia coli
missing residues 326-331, 403-410
total genus Genus: 159
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdgA00
3M8WA 1E2SP 1ELXA 1AJCA 1O99A 1URBA 1E1ZP 1EW2A 1ED9A 1ANJA 1E3CP 3BDGA 3SZZA 1KH4A 1EW9A 1Y7AA 1EQJA 1KHLA 2G9YA 1AJAA 3MK0A 3MK2A 3OT9A 1EJJA 1AJBA 1KHNA 1N2KA 1ELZA 3UN2A 1K7HA 1N2LA 3DYCA 3T00A 1ALJA 3MK1A 1KHKA 1Y6VA 2GLQA 1ZEDA 1ANIA 1O98A 1KHJA 1ZEFA 3T02A 1ED8A 3UN3A 3CMRA 3T01A 3SZYA 1ZEBA 3TX0A 2QZUA 4FDIA 1B8JA 3DPCA 3BDHA 3UO0A 3IGZB 3TWZA 1AUKA 4FDJA 2IFYA 2GA3A 1SHQA 3UN5A 1KH7A 1ALIA 3BDGB 1ALKA 1HDHA 1HQAA 1FSUA 3M8ZA 1SHNA 3UNYA 1URAA 1HJKA 1EW8A 3ED4A 1AJDA 1ELYA 3M7VA 1E33P 3IGYB 3NVLA 1P49A 1EI6A 3BDFA 1KH9A 3M8YA 2ANHA 1KH5A
chains in the KnotProt database with same CATH superfamily
3M8WA 1E2SP 1ELXA 1AJCA 1O99A 1URBA 1E1ZP 1EW2A 1ED9A 1ANJA 1E3CP 3BDGA 3SZZA 1KH4A 1EW9A 1Y7AA 1EQJA 1KHLA 2G9YA 1AJAA 3MK0A 3MK2A 3OT9A 1EJJA 1AJBA 1KHNA 1N2KA 1ELZA 3UN2A 1K7HA 1N2LA 3DYCA 3T00A 1ALJA 3MK1A 1KHKA 1Y6VA 2GLQA 1ZEDA 1ANIA 1O98A 1KHJA 1ZEFA 3T02A 1ED8A 3UN3A 3CMRA 3T01A 3SZYA 1ZEBA 3TX0A 2QZUA 4FDIA 1B8JA 3DPCA 3BDHA 3UO0A 3IGZB 3TWZA 1AUKA 4FDJA 2IFYA 2GA3A 1SHQA 3UN5A 1KH7A 1ALIA 3BDGB 1ALKA 1HDHA 1HQAA 1FSUA 3M8ZA 1SHNA 3UNYA 1URAA 1HJKA 1EW8A 3ED4A 1AJDA 1ELYA 3M7VA 1E33P 3IGYB 3NVLA 1P49A 1EI6A 3BDFA 1KH9A 3M8YA 2ANHA 1KH5A
chains in the KnotProt database with same CATH topology
3M8WA 1E2SP 1ELXA 1AJCA 1O99A 1URBA 1E1ZP 1EW2A 1ED9A 1ANJA 1E3CP 3BDGA 3SZZA 1KH4A 1EW9A 1Y7AA 1EQJA 1KHLA 2G9YA 1AJAA 3MK0A 3MK2A 3OT9A 1EJJA 1AJBA 1KHNA 1N2KA 1ELZA 3UN2A 1K7HA 1N2LA 3DYCA 3T00A 1ALJA 3MK1A 1KHKA 1Y6VA 2GLQA 1ZEDA 1ANIA 1O98A 1KHJA 1ZEFA 3T02A 1ED8A 3UN3A 3CMRA 3T01A 3SZYA 1ZEBA 3TX0A 2QZUA 4FDIA 1B8JA 3DPCA 3BDHA 3UO0A 3IGZB 3TWZA 1AUKA 4FDJA 2IFYA 2GA3A 1SHQA 3UN5A 1KH7A 1ALIA 3BDGB 1ALKA 1HDHA 1HQAA 1FSUA 3M8ZA 1SHNA 3UNYA 1URAA 1HJKA 1EW8A 3ED4A 1AJDA 1ELYA 3M7VA 1E33P 3IGYB 3NVLA 1P49A 1EI6A 3BDFA 1KH9A 3M8YA 2ANHA 1KH5A
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 3M8W A;  1E2S P;  1ELX A;  1AJC A;  1O99 A;  1URB A;  1E1Z P;  1EW2 A;  1ED9 A;  1ANJ A;  1E3C P;  3BDG A;  3SZZ A;  1KH4 A;  1EW9 A;  1Y7A A;  1EQJ A;  1KHL A;  2G9Y A;  1AJA A;  3MK0 A;  3MK2 A;  3OT9 A;  1EJJ A;  1AJB A;  1KHN A;  1N2K A;  1ELZ A;  3UN2 A;  1K7H A;  1N2L A;  3DYC A;  3T00 A;  1ALJ A;  3MK1 A;  1KHK A;  1Y6V A;  2GLQ A;  1ZED A;  1ANI A;  1O98 A;  1KHJ A;  1ZEF A;  3T02 A;  1ED8 A;  3UN3 A;  3CMR A;  3T01 A;  3SZY A;  1ZEB A;  3TX0 A;  2QZU A;  4FDI A;  1B8J A;  3DPC A;  3BDH A;  3UO0 A;  3IGZ B;  3TWZ A;  1AUK A;  4FDJ A;  2IFY A;  2GA3 A;  1SHQ A;  3UN5 A;  1KH7 A;  1ALI A;  3BDG B;  1ALK A;  1HDH A;  1HQA A;  1FSU A;  3M8Z A;  1SHN A;  3UNY A;  1URA A;  1HJK A;  1EW8 A;  3ED4 A;  1AJD A;  1ELY A;  3M7V A;  1E33 P;  3IGY B;  3NVL A;  1P49 A;  1EI6 A;  3BDF A;  1KH9 A;  3M8Y A;  2ANH A;  1KH5 A; 
#chains in the KnotProt database with same CATH topology
 3M8W A;  1E2S P;  1ELX A;  1AJC A;  1O99 A;  1URB A;  1E1Z P;  1EW2 A;  1ED9 A;  1ANJ A;  1E3C P;  3BDG A;  3SZZ A;  1KH4 A;  1EW9 A;  1Y7A A;  1EQJ A;  1KHL A;  2G9Y A;  1AJA A;  3MK0 A;  3MK2 A;  3OT9 A;  1EJJ A;  1AJB A;  1KHN A;  1N2K A;  1ELZ A;  3UN2 A;  1K7H A;  1N2L A;  3DYC A;  3T00 A;  1ALJ A;  3MK1 A;  1KHK A;  1Y6V A;  2GLQ A;  1ZED A;  1ANI A;  1O98 A;  1KHJ A;  1ZEF A;  3T02 A;  1ED8 A;  3UN3 A;  3CMR A;  3T01 A;  3SZY A;  1ZEB A;  3TX0 A;  2QZU A;  4FDI A;  1B8J A;  3DPC A;  3BDH A;  3UO0 A;  3IGZ B;  3TWZ A;  1AUK A;  4FDJ A;  2IFY A;  2GA3 A;  1SHQ A;  3UN5 A;  1KH7 A;  1ALI A;  3BDG B;  1ALK A;  1HDH A;  1HQA A;  1FSU A;  3M8Z A;  1SHN A;  3UNY A;  1URA A;  1HJK A;  1EW8 A;  3ED4 A;  1AJD A;  1ELY A;  3M7V A;  1E33 P;  3IGY B;  3NVL A;  1P49 A;  1EI6 A;  3BDF A;  1KH9 A;  3M8Y A;  2ANH A;  1KH5 A; 
#chains in the KnotProt database with same CATH homology
 3M8W A;  1E2S P;  1ELX A;  1AJC A;  1O99 A;  1URB A;  1E1Z P;  1EW2 A;  1ED9 A;  1ANJ A;  1E3C P;  3BDG A;  3SZZ A;  1KH4 A;  1EW9 A;  1Y7A A;  1EQJ A;  1KHL A;  2G9Y A;  1AJA A;  3MK0 A;  3MK2 A;  3OT9 A;  1EJJ A;  1AJB A;  1KHN A;  1N2K A;  1ELZ A;  3UN2 A;  1K7H A;  1N2L A;  3DYC A;  3T00 A;  1ALJ A;  3MK1 A;  1KHK A;  1Y6V A;  2GLQ A;  1ZED A;  1ANI A;  1O98 A;  1KHJ A;  1ZEF A;  3T02 A;  1ED8 A;  3UN3 A;  3CMR A;  3T01 A;  3SZY A;  1ZEB A;  3TX0 A;  2QZU A;  4FDI A;  1B8J A;  3DPC A;  3BDH A;  3UO0 A;  3IGZ B;  3TWZ A;  1AUK A;  4FDJ A;  2IFY A;  2GA3 A;  1SHQ A;  3UN5 A;  1KH7 A;  1ALI A;  3BDG B;  1ALK A;  1HDH A;  1HQA A;  1FSU A;  3M8Z A;  1SHN A;  3UNY A;  1URA A;  1HJK A;  1EW8 A;  3ED4 A;  1AJD A;  1ELY A;  3M7V A;  1E33 P;  3IGY B;  3NVL A;  1P49 A;  1EI6 A;  3BDF A;  1KH9 A;  3M8Y A;  2ANH A;  1KH5 A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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