4MTYA

Structure at 1a resolution of a helical aromatic foldamer-protein complex.
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 24-254 231 1-23, 255-258 23 4 knot
Chain Sequence
HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 15x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 25-255 231 1-24, 256-258 24 3 knot
Fingerprint Knot forming loop Loop type
K +31 His3 ... His94 <->
Bridging ionZn301
<-> His96 ...
Chain closureLys260 <-> His3
probabilistic
K +31
Chain closureHis3 <-> Lys260
... Cys205 <->
Bridging ionHgb304
<-> Gln136 ... His3
probabilistic
K +31
Chain closureHis3 <-> Lys260
... Cys205 <->
Bridging ionHg309
<-> Val134 ... His3
probabilistic
K +31
Chain closureHis3 <-> Lys260
... Glu204 <->
Bridging ionHgb304
<-> Gln136 ... His3
probabilistic
K +31 His3 ... His96 <->
Bridging ionZn301
<-> His119 ...
Chain closureLys260 <-> His3
probabilistic
K +31 His3 ... His94 <->
Bridging ionZn301
<-> His119 ...
Chain closureLys260 <-> His3
probabilistic
K +31
Chain closureHis3 <-> Lys260
... Cys205 <->
Bridging ionHgb304
<-> Gln136 ... His96 <->
Bridging ionZn301
<-> His94 ... His3
probabilistic
K +31
Chain closureHis3 <-> Lys260
... Cys205 <->
Bridging ionHg309
<-> Val134 ... His96 <->
Bridging ionZn301
<-> His94 ... His3
probabilistic
K +31
Chain closureHis3 <-> Lys260
... Glu204 <->
Bridging ionHgb304
<-> Gln136 ... His96 <->
Bridging ionZn301
<-> His94 ... His3
probabilistic
K +31
Chain closureHis3 <-> Lys260
... Cys205 <->
Bridging ionHgb304
<-> Gln136 ... His119 <->
Bridging ionZn301
<-> His96 ... His3
probabilistic
K +31
Chain closureHis3 <-> Lys260
... Cys205 <->
Bridging ionHg309
<-> Val134 ... His119 <->
Bridging ionZn301
<-> His96 ... His3
probabilistic
K +31
Chain closureHis3 <-> Lys260
... Glu204 <->
Bridging ionHgb304
<-> Gln136 ... His119 <->
Bridging ionZn301
<-> His96 ... His3
probabilistic
K +31
Chain closureHis3 <-> Lys260
... Cys205 <->
Bridging ionHgb304
<-> Gln136 ... His119 <->
Bridging ionZn301
<-> His94 ... His3
probabilistic
K +31
Chain closureHis3 <-> Lys260
... Cys205 <->
Bridging ionHg309
<-> Val134 ... His119 <->
Bridging ionZn301
<-> His94 ... His3
probabilistic
K +31
Chain closureHis3 <-> Lys260
... Glu204 <->
Bridging ionHgb304
<-> Gln136 ... His119 <->
Bridging ionZn301
<-> His94 ... His3
probabilistic
Chain Sequence
HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 26-252 227 1-25 258-258 253-257 25 1 slipknot
publication title Structure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 a resolution.
pubmed doi rcsb
structure length 258
molecule tags Lyase/lyase inhibitor
source organism Homo sapiens
sequence length 258
molecule keywords Carbonic anhydrase 2
ec nomenclature ec 4.2.1.1: Carbonate dehydratase.
pdb deposition date 2013-09-20
KnotProt deposition date 2018-10-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00194 Carb_anhydrase Eukaryotic-type carbonic anhydrase
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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