4OQXA

Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with me-ara-edu
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31
Knot core rangeKnot core lengthKnot tails rangeSlipknot tails rangeSlipknot loops rangeN-end lengthC-end lengthType
view details
+31 6-118 113 1-5 307-330 119-306 5 24 slipknot
Chain Sequence
KMPTLLRVYIDGPHGMGKTTTTQLLVA--SRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAPP-----PALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQCGGSWREDWGQLSGPRPHIGD---------------TLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGE
sequence length 330
structure length 308
publication title Crystal structure of HSV1-TK complexed with Me-ARA-EdU
rcsb
molecule tags Transferase
molecule keywords Thymidine kinase
source organism Human herpesvirus 1
missing residues 28-29, 104-108, 221-235
ec nomenclature ec 2.7.1.21: Thymidine kinase.
pdb deposition date2014-02-10
KnotProt deposition date2014-08-16
Image from the rcsb pdb (www.rcsb.org)
1E2KA 4IVQA 1OF1A 4JBYA 1E2HA 1E2IA 4JBXA 1QHIA 4IVPA 4OQLA 3F0TA 2KI5A 4OQMA 1KI2A 1KIMA 1KI8A 1KI7A 1E2NA 4OQNA 1E2MA 1P7CA 1KI3A 4IVRA 1KI4A 4OQXA 1E2LA 1KI6A 1KI6B 1E2PA 1E2JA 2VTKA 1VTKA 3RDPA 3VTKA
similar chains in the KnotProt database (40% sequence similarity)
1E2KB 4IVQB 1OF1B 4JBYB 1E2HB 1E2IB 4JBXB 1QHIB 4IVPB 4OQLB 3F0TB 2KI5B 4OQMB 1KI2B 1KIMB 1KI8B 1KI7B 1E2NB 4OQNB 1E2MB 1P7CB 1KI3B 4IVRB 1KI4B 4OQXB 1E2LB 1E2PB 1E2JB 3RDPB
similar chains in the pdb database (40% sequence similarity)

 
            
               
#similar chains in the KnotProt database (40% sequence similarity)
 1E2K A;  4IVQ A;  1OF1 A;  4JBY A;  1E2H A;  1E2I A;  4JBX A;  1QHI A;  4IVP A;  4OQL A;  3F0T A;  2KI5 A;  4OQM A;  1KI2 A;  1KIM A;  1KI8 A;  1KI7 A;  1E2N A;  4OQN A;  1E2M A;  1P7C A;  1KI3 A;  4IVR A;  1KI4 A;  4OQX A;  1E2L A;  1KI6 A;  1KI6 B;  1E2P A;  1E2J A;  2VTK A;  1VTK A;  3RDP A;  3VTK A; 
               
               
           
#similar chains in the pdb database (40% sequence similarity)
 1E2K B;  4IVQ B;  1OF1 B;  4JBY B;  1E2H B;  1E2I B;  4JBX B;  1QHI B;  4IVP B;  4OQL B;  3F0T B;  2KI5 B;  4OQM B;  1KI2 B;  1KIM B;  1KI8 B;  1KI7 B;  1E2N B;  4OQN B;  1E2M B;  1P7C B;  1KI3 B;  4IVR B;  1KI4 B;  4OQX B;  1E2L B;  1E2P B;  1E2J B;  3RDP B; 
           

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