4M48A

X-ray structure of dopamine transporter elucidates antidepressant mechanism
Slipknot S +31 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 39-268 230 269-532 1-22 23-38 22 263 slipknot
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41 14-295 282 1-13 350-532 296-349 13 183 slipknot
Chain Sequence
DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLAVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAALLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWADAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLATLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYLLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 13-290 278 1-12 302-532 291-301 12 231 slipknot
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4.1 10-301 292 1-9 315-532 302-314 9 218 slipknot
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3.2 9-318 310 1-8 345-532 319-344 8 188 slipknot
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4.1 20-331 312 1-19 349-532 332-348 19 184 slipknot
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4.1 20-348 329 1-19 353-532 349-352 19 180 slipknot
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3.2 21-331 311 1-19, 349-532 20-20, 332-348 19 184 slipknot
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3.2 22-332 311 1-20, 349-532 21-21, 333-348 20 184 slipknot
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3.2 22-349 328 1-20, 353-532 21-21, 350-352 20 180 slipknot
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3.2 12-316 305 1-5, 324-532 6-11, 317-323 5 209 slipknot
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3.2 16-328 313 1-8, 332-532 9-15, 329-331 8 201 slipknot
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3.2m 18-301 284 1-10, 308-532 11-17, 302-307 10 225 slipknot
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2.1 43-357 315 1-18, 396-532 19-42, 358-395 18 137 slipknot
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2.1 44-417 374 418-532 1-18 19-43 18 114 slipknot
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2.1 35-263 229 1-20, 277-532 21-34, 264-276 20 256 slipknot
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1.1 31-250 220 1-22, 259-532 23-30, 251-258 22 274 slipknot
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1.1 44-280 237 1-24, 299-532 25-43, 281-298 24 234 slipknot
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1.1 39-248 210 1-25, 261-532 26-38, 249-260 25 272 slipknot
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2.1 40-400 361 1-32, 410-532 33-39, 401-409 32 123 slipknot
sequence length 532
structure length 532
publication title X-ray structure of dopamine transporter elucidates antidepressant mechanism.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Transporter
source organism Drosophila melanogaster
total genus Genus: 218
ec nomenclature
pdb deposition date 2013-08-06
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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