4MM4A

Crystal structure of leubat (delta13 mutant) in complex with paroxetine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 37-264 228 265-507 1-20 21-36 20 242 slipknot
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41 13-294 282 1-12 348-507 295-347 12 160 slipknot
Chain Sequence
REHWATRLGLILAMAGYAVDLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVASYYVYIESWTLGFAIKFLVGLVPEPP---TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFSLGLGFGVLITFASYVRKDQDIVLSGLTAATLNEKASVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAGMQGMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWATGIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYTHW-------TVWITRFYIIGLFLFLTFLVFLAERRRNHE
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 11-287 277 1-10 301-497 288-300 10 197 slipknot
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3.2 10-300 291 1-9 307-497 301-306 9 191 slipknot
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3.2 10-331 322 1-9 346-497 332-345 9 152 slipknot
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4.1 8-326 319 1-2, 331-497 3-7, 327-330 2 167 slipknot
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4.1 8-330 323 1-2, 332-497 3-7, 331-331 2 166 slipknot
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3.2 9-314 306 1-3, 319-497 4-8, 315-318 3 179 slipknot
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4.1 9-320 312 1-3, 325-497 4-8, 321-324 3 173 slipknot
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3.2m 12-296 285 1-9, 307-497 10-11, 297-306 9 191 slipknot
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3.2 12-325 314 1-6, 331-497 7-11, 326-330 6 167 slipknot
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3.2 12-330 319 1-7, 332-497 8-11, 331-331 7 166 slipknot
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3.2 14-313 300 1-8, 319-497 9-13, 314-318 8 179 slipknot
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2.1 29-258 230 1-15, 271-497 16-28, 259-270 15 227 slipknot
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2.1 40-353 314 1-17, 397-497 18-39, 354-396 17 101 slipknot
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2.1 41-411 371 412-497 1-18 19-40 18 85 slipknot
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1.1 38-242 205 1-23, 258-497 24-37, 243-257 23 240 slipknot
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1.1 41-275 235 1-25, 294-497 26-40, 276-293 25 204 slipknot
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2.1 33-258 226 1-28, 264-497 29-32, 259-263 28 234 slipknot
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2.1 39-261 223 1-29, 272-497 30-38, 262-271 29 226 slipknot
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2.1 37-401 365 1-30, 408-497 31-36, 402-407 30 90 slipknot
sequence length 507
structure length 497
publication title Structural basis for action by diverse antidepressants on biogenic amine transporters.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Transporter
source organism Aquifex aeolicus
missing residues 128-130, 468-474
total genus Genus: 205
ec nomenclature
pdb deposition date 2013-09-08
KnotProt deposition date 2014-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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