4YX4A

Human carbonic anhydrase ii complexed with an inhibitor with a benzenesulfonamide group (1).
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 24-254 231 255-258 1-1 2-23 1 3 slipknot
Chain Sequence
HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 11x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 24-255 232 1-23, 256-258 23 3 knot
Fingerprint Knot forming loop Loop type
K +31 His4 ... His94 <->
Bridging ionZn301
<-> His96 ...
Chain closureLys261 <-> His4
probabilistic
K +31
Chain closureHis4 <-> Lys261
... Cys206 <->
Bridging ionMbo302
<-> Gln137 ... His4
probabilistic
K +31 His4 ... His96 <->
Bridging ionZn301
<-> His119 ...
Chain closureLys261 <-> His4
probabilistic
K +31 His4 ... His94 <->
Bridging ionZn301
<-> His119 ...
Chain closureLys261 <-> His4
probabilistic
K +31
Chain closureHis4 <-> Lys261
... Glu205 <->
Bridging ionMbo302
<-> Gln137 ... His4
probabilistic
K +31
Chain closureHis4 <-> Lys261
... Cys206 <->
Bridging ionMbo302
<-> Gln137 ... His96 <->
Bridging ionZn301
<-> His94 ... His4
probabilistic
K +31
Chain closureHis4 <-> Lys261
... Cys206 <->
Bridging ionMbo302
<-> Gln137 ... His119 <->
Bridging ionZn301
<-> His96 ... His4
probabilistic
K +31
Chain closureHis4 <-> Lys261
... Cys206 <->
Bridging ionMbo302
<-> Gln137 ... His119 <->
Bridging ionZn301
<-> His94 ... His4
probabilistic
K +31
Chain closureHis4 <-> Lys261
... Glu205 <->
Bridging ionMbo302
<-> Gln137 ... His96 <->
Bridging ionZn301
<-> His94 ... His4
probabilistic
K +31
Chain closureHis4 <-> Lys261
... Glu205 <->
Bridging ionMbo302
<-> Gln137 ... His119 <->
Bridging ionZn301
<-> His96 ... His4
probabilistic
K +31
Chain closureHis4 <-> Lys261
... Glu205 <->
Bridging ionMbo302
<-> Gln137 ... His119 <->
Bridging ionZn301
<-> His94 ... His4
probabilistic
Chain Sequence
HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 25-255 231 1-24, 256-257 24 2 knot
view details
2.1 24-251 228 1-23 257-257 252-256 23 1 slipknot
view details
3.1 26-255 230 256-257 1-24 25-25 24 1 slipknot
sequence length 257
structure length 257
publication title Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies.
pubmed doi rcsb
molecule tags Lyase
molecule keywords Carbonic anhydrase 2
source organism Homo sapiens
total genus Genus: 76
ec nomenclature
pdb deposition date 2015-03-22
KnotProt deposition date 2018-10-19
Image from the rcsb pdb (www.rcsb.org)
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