5CJLA

Crystal structure of human carbonic anhydrase ii in complex with a heteroaryl-pyrazole carboxylic acid derivative.
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 26-253 228 1-25, 254-257 25 4 knot
Chain Sequence
HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
sequence length 257
structure length 257
publication title Exploration of substituted heteroaryl-pyrazole carboxylic acid derivatives as novel human carbonic anhydrase cytosolic isozymes I and II, and transmembrane tumor-associated isozymes IX and XII.
rcsb
molecule tags Lyase/lyase inhibitor
molecule keywords Carbonic anhydrase 2
source organism Homo sapiens
ec nomenclature
pdb deposition date 2015-07-14
KnotProt deposition date 2016-09-28
Image from the rcsb pdb (www.rcsb.org)
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5



Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 20-256 237 1-19, 257-257 19 1 knot
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2.1 24-251 228 1-23 257-257 252-256 23 1 slipknot
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2.1 26-255 230 256-257 1-20 21-25 20 1 slipknot
5CJLA
similar chains in the KnotProt database (40% sequence similarity)

 
            
               
#similar chains in the KnotProt database (40% sequence similarity)
 5CJL A; 
               
               
           

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