5DLVA

Crystal structure of autotaxin (enpp2) with tauroursodeoxycholic acid (tudca)
Slipknot S +31
Knot core rangeKnot core lengthKnot tails rangeSlipknot tails rangeSlipknot loops rangeN-end lengthC-end lengthType
view details
+31 116-301 186 1-115 432-804 302-431 115 373 slipknot
Chain Sequence
GSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIKVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDASFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKSINNSKYDPKTIIAALTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPLDV-------CFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPDEVSRPNYPGIMYLQSEFDLGCTCDHTKGSTK----------------ERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWAYFQRVLVKKYASERNGVNVISGPIFDYNYDGLRDTEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCASSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYE
sequence length 804
structure length 781
publication title Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
doi rcsb
molecule tags Hydrolase
molecule keywords Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
source organism Rattus norvegicus
missing residues 406-412, 515-530
ec nomenclature
pdb deposition date2015-09-07
KnotProt deposition date2016-04-15
Image from the rcsb pdb (www.rcsb.org)
4ZG7A 3NKQA 3NKRA 3WAYA 3NKOA 3NKPA 3NKNA 3WAVA 5DLWA 3WAXA 3NKMA 4ZG6A 5IJQA 3WAWA 2XR9A 5DLVA 5IJSA 5M0SA 4GTWA 4B56A 2XRGA 4GTXA 4GTZA 4GTYA
similar chains in the KnotProt database (40% sequence similarity)
5DLTA 5INHA 5LIAA 5HRTA 4ZG6B 5M0EA 5DLVB 5GZ5A 5M0MA 5L0BA 5L0BB 5KXAA 5MHPA 5LQQA 5M0DA 4ZGAA 4ZG9A 4ZG9B 5GZ4A 5L0EA 5L0EB 5L0KA 5L0KB 5M7MA 4GTWB 4B56B 4GTXB 4GTZB 4GTYB
similar chains in the pdb database (40% sequence similarity)

 
            
               
#similar chains in the KnotProt database (40% sequence similarity)
 4ZG7 A;  3NKQ A;  3NKR A;  3WAY A;  3NKO A;  3NKP A;  3NKN A;  3WAV A;  5DLW A;  3WAX A;  3NKM A;  4ZG6 A;  5IJQ A;  3WAW A;  2XR9 A;  5DLV A;  5IJS A;  5M0S A;  4GTW A;  4B56 A;  2XRG A;  4GTX A;  4GTZ A;  4GTY A; 
               
               
           
#similar chains in the pdb database (40% sequence similarity)
 5DLT A;  5INH A;  5LIA A;  5HRT A;  4ZG6 B;  5M0E A;  5DLV B;  5GZ5 A;  5M0M A;  5L0B A;  5L0B B;  5KXA A;  5MHP A;  5LQQ A;  5M0D A;  4ZGA A;  4ZG9 A;  4ZG9 B;  5GZ4 A;  5L0E A;  5L0E B;  5L0K A;  5L0K B;  5M7M A;  4GTW B;  4B56 B;  4GTX B;  4GTZ B;  4GTY B; 
           

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