5DLWA

Crystal structure of autotaxin (enpp2) with tauroursodeoxycholic acid (tudca) and lysophosphatidic acid (lpa)
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 115-302 188 1-114 432-805 303-431 114 374 slipknot
Chain Sequence
GSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIKVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDASFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKS-----YDPKTIIAALTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPDEVSRPNYPGIMYLQSEFDLGCTCDDSTKER-------------------HLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWAYFQRVLVKKYASERNGVNVISGPIFDYNYDGLRDTEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCASSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYES
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 50-300 251 1-49 307-781 301-306 49 475 slipknot
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3.1 114-303 190 1-113 424-781 304-423 113 358 slipknot
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3.1 114-423 310 1-113 426-781 424-425 113 356 slipknot
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3.1 111-302 192 1-98, 304-781 99-110, 303-303 98 478 slipknot
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3.1 115-410 296 1-113, 421-781 114-114, 411-420 113 361 slipknot
missing residues 342-346, 516-534
publication title Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
doi rcsb
structure length 781
molecule tags Hydrolase
source organism Rattus norvegicus
sequence length 805
molecule keywords Ectonucleotide pyrophosphatase/phosphodiesterase family memb
ec nomenclature
pdb deposition date 2015-09-07
KnotProt deposition date 2016-04-15
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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