5DLWA

Crystal structure of autotaxin (enpp2) with tauroursodeoxycholic acid (tudca) and lysophosphatidic acid (lpa)
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 115-302 188 1-114 432-805 303-431 114 374 slipknot
Chain Sequence
GSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIKVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDASFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKS-----YDPKTIIAALTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPDEVSRPNYPGIMYLQSEFDLGCTCDDSTKER-------------------HLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWAYFQRVLVKKYASERNGVNVISGPIFDYNYDGLRDTEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCASSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYES
sequence length 805
structure length 781
publication title Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
doi rcsb
molecule tags Hydrolase
molecule keywords Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
source organism Rattus norvegicus
missing residues 342-346, 516-534
ec nomenclature
pdb deposition date 2015-09-07
KnotProt deposition date 2016-04-15
Image from the rcsb pdb (www.rcsb.org)
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5



Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 50-300 251 1-49 307-781 301-306 49 475 slipknot
view details
3.1 114-303 190 1-113 424-781 304-423 113 358 slipknot
view details
3.1 114-423 310 1-113 426-781 424-425 113 356 slipknot
view details
3.1 111-302 192 1-98, 304-781 99-110, 303-303 98 478 slipknot
view details
3.1 115-410 296 1-113, 421-781 114-114, 411-420 113 361 slipknot
5OHIA 4ZG7A 3NKQA 3NKRA 3WAYA 3NKOA 3NKPA 5OLBA 3NKNA 3WAVA 5DLWA 3WAXA 3NKMA 4ZG6A 5IJQA 3WAWA 2XR9A 5DLVA 5IJSA 5M0SA 4GTWA 4B56A 2XRGA 4GTXA 4GTZA 4GTYA
similar chains in the KnotProt database (40% sequence similarity)
5DLTA 5INHA 5LIAA 6C02A 6C02B 5HRTA 4ZG6B 5M0EA 5DLVB 5GZ5A 5M0MA 6C01A 6C01B 5L0BA 5L0BB 5KXAA 5MHPA 5LQQA 5M0DA 4ZGAA 4ZG9A 4ZG9B 5GZ4A 5L0EA 5L0EB 5L0KA 5L0KB 5M7MA 4GTWB 4B56B 4GTXB 4GTZB 4GTYB
similar chains in the pdb database (40% sequence similarity)

 
            
               
#similar chains in the KnotProt database (40% sequence similarity)
 5OHI A;  4ZG7 A;  3NKQ A;  3NKR A;  3WAY A;  3NKO A;  3NKP A;  5OLB A;  3NKN A;  3WAV A;  5DLW A;  3WAX A;  3NKM A;  4ZG6 A;  5IJQ A;  3WAW A;  2XR9 A;  5DLV A;  5IJS A;  5M0S A;  4GTW A;  4B56 A;  2XRG A;  4GTX A;  4GTZ A;  4GTY A; 
               
               
           
#similar chains in the pdb database (40% sequence similarity)
 5DLT A;  5INH A;  5LIA A;  6C02 A;  6C02 B;  5HRT A;  4ZG6 B;  5M0E A;  5DLV B;  5GZ5 A;  5M0M A;  6C01 A;  6C01 B;  5L0B A;  5L0B B;  5KXA A;  5MHP A;  5LQQ A;  5M0D A;  4ZGA A;  4ZG9 A;  4ZG9 B;  5GZ4 A;  5L0E A;  5L0E B;  5L0K A;  5L0K B;  5M7M A;  4GTW B;  4B56 B;  4GTX B;  4GTZ B;  4GTY B; 
           

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