5FQLA

Insights into hunter syndrome from the structure of iduronate-2- sulfatase
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 7-302 296 1-6 325-517 303-324 6 193 slipknot
Chain Sequence
TDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAV-APSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVELCREGKNLLKHFRP----------GNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYNDSQGGDLFQLLMP
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 4-300 297 1-3 306-506 301-305 3 201 slipknot
view details
4.2m 5-305 301 1-4 311-506 306-310 4 196 slipknot
view details
3.1 6-311 306 1-5 323-506 312-322 5 184 slipknot
view details
3.1 5-322 318 1-4 324-506 323-323 4 183 slipknot
view details
2.1 4-323 320 1-3 325-506 324-324 3 182 slipknot
missing residues 51, 411-420
publication title Insights Into Hunter Syndrome from the Structure of Iduronate-2-Sulfatase
rcsb
structure length 506
molecule tags Hydrolase
source organism Homo sapiens
sequence length 517
molecule keywords IDURONATE-2-SULFATASE
ec nomenclature
pdb deposition date 2015-12-11
KnotProt deposition date 2017-01-19
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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