5L9EA

Crystal structure of human carbonic anhydrase ii in complex with a quinoline oligoamide foldamer
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 26-256 231 1-25, 257-259 25 3 knot
Chain Sequence
SHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 7x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 25-254 230 1-24, 255-259 24 4 slipknot
Fingerprint Knot forming loop Loop type
K +31 Ser2 ... Asp34 <->
Bridging ionZn310
<-> His36 ...
Chain closureLys260 <-> Ser2
probabilistic
K +31 Ser2 ... His94 <->
Bridging ionZn301
<-> His96 ...
Chain closureLys260 <-> Ser2
probabilistic
K +31 Ser2 ... His96 <->
Bridging ionZn301
<-> His119 ...
Chain closureLys260 <-> Ser2
probabilistic
K +31 Ser2 ... His94 <->
Bridging ionZn301
<-> His119 ...
Chain closureLys260 <-> Ser2
probabilistic
K +31 Ser2 ... Asp34 <->
Bridging ionZn310
<-> His36 ... His94 <->
Bridging ionZn301
<-> His96 ...
Chain closureLys260 <-> Ser2
probabilistic
K +31 Ser2 ... Asp34 <->
Bridging ionZn310
<-> His36 ... His96 <->
Bridging ionZn301
<-> His119 ...
Chain closureLys260 <-> Ser2
probabilistic
K +31 Ser2 ... Asp34 <->
Bridging ionZn310
<-> His36 ... His94 <->
Bridging ionZn301
<-> His119 ...
Chain closureLys260 <-> Ser2
probabilistic
Chain Sequence
SHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 28-257 230 1-27, 258-259 27 2 knot
view details
2.1 26-253 228 1-25 258-259 254-257 25 2 slipknot
publication title CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A QUINOLINE OLIGOAMIDE FOLDAMER
rcsb
structure length 259
molecule tags Lyase/inhibitor
source organism Homo sapiens
sequence length 259
molecule keywords Carbonic anhydrase 2
ec nomenclature
pdb deposition date 2016-06-10
KnotProt deposition date 2018-10-03
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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