5LL9A

Crystal structure of human carbonic anhydrase isozyme xii with 4-(1h-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 24-257 234 1-23, 258-261 23 4 knot
Chain Sequence
KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 3x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 26-234 209 1-25, 235-239 25 5 knot
Fingerprint Knot forming loop Loop type
K +31
Chain closureLys3 <-> Gln263
... His117 <->
Bridging ionZn301
<-> His93 ... Lys3
probabilistic
K +31
Chain closureLys3 <-> Gln263
... His117 <->
Bridging ionZn301
<-> His91 ... Lys3
probabilistic
K +31
Chain closureLys3 <-> Gln263
... His93 <->
Bridging ionZn301
<-> His91 ... Lys3
probabilistic
Chain Sequence
KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 26-258 233 1-25, 259-261 25 3 knot
view details
2.1 24-254 231 1-23 259-261 255-258 23 3 slipknot
publication title Combinatorial Design of Isoform-Selective N-Alkylated Benzimidazole-Based Inhibitors of Carbonic Anhydrases
doi rcsb
structure length 261
molecule tags Lyase
source organism Homo sapiens
sequence length 261
molecule keywords Carbonic anhydrase 12
ec nomenclature
pdb deposition date 2016-07-27
KnotProt deposition date 2018-10-04
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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