5MSAA

Crystal structure of human carbonic anhydrase isozyme xii with 2,3,5,6-tetrafluoro-4-(propylthio)benzenesulfonamide
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 26-256 231 1-25, 257-261 25 5 knot
Chain Sequence
KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 3x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 26-234 209 1-25, 235-239 25 5 knot
Fingerprint Knot forming loop Loop type
K +31
Chain closureLys3 <-> Gln263
... His117 <->
Bridging ionZn301
<-> His93 ... Lys3
probabilistic
K +31
Chain closureLys3 <-> Gln263
... His117 <->
Bridging ionZn301
<-> His91 ... Lys3
probabilistic
K +31
Chain closureLys3 <-> Gln263
... His93 <->
Bridging ionZn301
<-> His91 ... Lys3
probabilistic
Chain Sequence
KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 26-258 233 1-25, 259-261 25 3 knot
view details
2.1 25-254 230 1-24 259-261 255-258 24 3 slipknot
publication title Crystal structure of human carbonic anhydrase isozyme XII with 2,3,5,6-Tetrafluoro-4-(propylthio)benzenesulfonamide
rcsb
structure length 261
molecule tags Lyase
source organism Homo sapiens
sequence length 261
molecule keywords Carbonic anhydrase 12
ec nomenclature
pdb deposition date 2017-01-02
KnotProt deposition date 2018-10-20
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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