5UDYA

Human alkaline sphingomyelinase (alk-smase, enpp7, npp7)
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 9-217 209 1-8 335-388 218-334 8 54 slipknot
Chain Sequence
QNKLLLVSFDGFRWNYDQDVDTPNLDAMARDGVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMYYNTTSKVKLPYHATLGIQRWWDNGSVPIWITAQRQGLRAGSFFYPGGNVTYQGVAVTRSRKEGIAHNYKNETEWRANIDTVMAWFTEEDLDLVTLYFGEPDSTGHRYGPESPERREMVRQVDRTVGYLRESIARNHLTDRLNLIITSDHGMTTVDKRAGDLVEFHKFPNFTFRDIEFELLDYGPNGMLLPKEGRLEKVYDALKDAHPKLHVYKKEAFPEAFHYANNPRVTPLLMYSDLGYVIHGRINVQFNNGEHGFDNKDMDMKTIFRAVGPSFRAGLEVEPFESVHVYELMCRLLGIVPEANDGHLATLLPMLHTES
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 5-217 213 1-4 222-388 218-221 4 167 slipknot
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3.1 8-221 214 1-7 252-388 222-251 7 137 slipknot
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3.1 6-254 249 1-5 278-388 255-277 5 111 slipknot
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3.1 8-278 271 1-7 323-388 279-322 7 66 slipknot
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3.1 7-256 250 1-5, 259-388 6-6, 257-258 5 130 slipknot
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2.1 7-323 317 1-2, 331-388 3-6, 324-330 2 58 slipknot
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3.1 9-283 275 1-7, 289-388 8-8, 284-288 7 100 slipknot
publication title Crystal Structure of the Human Alkaline Sphingomyelinase Provides Insights into Substrate Recognition.
pubmed doi rcsb
structure length 388
molecule tags Hydrolase
source organism Homo sapiens
sequence length 388
molecule keywords Ectonucleotide pyrophosphatase/phosphodiesterase family memb
ec nomenclature
pdb deposition date 2016-12-28
KnotProt deposition date 2017-03-27
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the pdb database (?% sequence similarity)

 
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