5YLCA

Crystal structure of mcr-1 catalytic domain
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 26-248 223 1-25 277-330 249-276 25 54 slipknot
Chain Sequence
KDTIYHAKDAVQATKPDMRKPRLVVFVVGETARADHVSFNGYERDTFPQLAKIDGVTNFSNVTSCGTS-AYSVPCMFSYLGADEYDVDTAKYQENVLDTLDRLGVSILWRDNNSDSKGVMDKLPKAQFADYKSATNNAICNTNPYNECRDVGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHGESLGENGVYLHGMPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTHDAITPTLLKLFDVTADKVKDRTAFIRLEHHH
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5



Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 9-246 238 1-8 252-329 247-251 8 78 slipknot
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3.1 25-249 225 1-24 275-329 250-274 24 55 slipknot
view details
3.1 15-274 260 1-7, 277-329 8-14, 275-276 7 53 slipknot
view details
2.1 15-276 262 1-9, 278-329 10-14, 277-277 9 52 slipknot
view details
2.1 22-274 253 1-14, 277-329 15-21, 275-276 14 53 slipknot
view details
2.1 21-276 256 1-15, 278-329 16-20, 277-277 15 52 slipknot
sequence length 330
structure length 329
publication title Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance.
pubmed doi rcsb
molecule tags Transferase
molecule keywords Probable phosphatidylethanolamine transferase Mcr-1
source organism Escherichia coli
missing residues 69
ec nomenclature
pdb deposition date 2017-10-17
KnotProt deposition date 2017-11-08
Image from the rcsb pdb (www.rcsb.org)
5MX9A 5K4PA 4KAVA 5GRRA 5YLCA 5YLFA 4KAYA 5LRMA 5YLEA 5GOVA 4TN0A 5LRNA
similar chains in the KnotProt database (40% sequence similarity)
6BNCA 6BNCB 5LRNB 6BNDA 6BNDB 4KAYB 5ZJVA 5GOVB 6BNFA 4TN0B 4TN0C 6BNEA
similar chains in the pdb database (40% sequence similarity)

 
            
               
#similar chains in the KnotProt database (40% sequence similarity)
 5MX9 A;  5K4P A;  4KAV A;  5GRR A;  5YLC A;  5YLF A;  4KAY A;  5LRM A;  5YLE A;  5GOV A;  4TN0 A; 
               
               
#similar chains, but unknotted
 5LRN A;                               
               
           
#similar chains in the pdb database (40% sequence similarity)
 6BNC A;  6BNC B;  5LRN B;  6BND A;  6BND B;  4KAY B;  5ZJV A;  5GOV B;  6BNF A;  4TN0 B;  4TN0 C;  6BNE A; 
           

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