6AWNA

X-ray structure of the s439t human serotonin transporter complexed with paroxetine at the central site
Slipknot S +31 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 42-273 232 1-24, 544-544 25-41, 274-543 24 1 slipknot
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41 19-305 287 1-18 364-544 306-363 18 181 slipknot
Chain Sequence
GSQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICAQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIALSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIIASFLMSPPQLRLFQYNYPYWSIILGYAIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5



Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 15-301 287 1-14 313-544 302-312 14 232 slipknot
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4.1 16-311 296 1-15 325-544 312-324 15 220 slipknot
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4.1 16-324 309 1-15 338-544 325-337 15 207 slipknot
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3.2 23-348 326 1-4, 364-544 5-22, 349-363 4 181 slipknot
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2.1 25-276 252 1-19, 286-544 20-24, 277-285 19 259 slipknot
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2.1 26-384 359 1-20, 397-544 21-25, 385-396 20 148 slipknot
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2.1 45-425 381 426-544 1-20 21-44 20 118 slipknot
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2.1 46-369 324 1-21, 409-544 22-45, 370-408 21 136 slipknot
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1.1 40-293 254 1-22, 308-544 23-39, 294-307 22 237 slipknot
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2.1 38-271 234 1-23, 292-544 24-37, 272-291 23 253 slipknot
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1.1 34-259 226 1-27, 269-544 28-33, 260-268 27 276 slipknot
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1.1 45-291 247 1-30, 309-544 31-44, 292-308 30 236 slipknot
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1.1 42-257 216 1-33, 273-544 34-41, 258-272 33 272 slipknot
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2.1 42-411 370 1-34, 417-544 35-41, 412-416 34 128 slipknot
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2.1 45-274 230 1-38, 288-544 39-44, 275-287 38 257 slipknot
sequence length 544
structure length 544
publication title Structural basis for recognition of diverse antidepressants by the human serotonin transporter
rcsb
molecule tags Transport protein
molecule keywords Sodium-dependent serotonin transporter
source organism Homo sapiens
ec nomenclature
pdb deposition date 2017-09-06
KnotProt deposition date 2017-10-25
Image from the rcsb pdb (www.rcsb.org)
4XP9C 4XP1A 4XP4A 4M48A 4XNXA 4XNUA 4XPAA 4XPHA 4XP6A 4XPBA 4XPTA 4XPFA 4XPGA 4XP5A 6AWNA 6AWOA 6AWPA 6AWQA
similar chains in the KnotProt database (40% sequence similarity)
5I6XA 5I71A 5I73A 5I74A 5I75A 5I6ZA
similar chains in the pdb database (40% sequence similarity)

 
            
               
#similar chains in the KnotProt database (40% sequence similarity)
 4XP9 C;  4XP1 A;  4XP4 A;  4M48 A;  4XNX A;  4XNU A;  4XPA A;  4XPH A;  4XP6 A;  4XPB A;  4XPT A;  4XPF A;  4XPG A;  4XP5 A;  6AWN A;  6AWO A;  6AWP A;  6AWQ A; 
               
               
           
#similar chains in the pdb database (40% sequence similarity)
 5I6X A;  5I71 A;  5I73 A;  5I74 A;  5I75 A;  5I6Z A; 
           

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