6AWPA

X-ray structure of the ts3 human serotonin transporter complexed with fluvoxamine at the central site
Slipknot S +31 41 +31
Knot core rangeKnot core lengthKnot tails rangeSlipknot tails rangeSlipknot loops rangeN-end lengthC-end lengthType
view details
+31 42-276 235 277-544 1-24 25-41 24 267 slipknot
view details
41 19-305 287 1-18 367-544 306-366 18 178 slipknot
Chain Sequence
GSQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICAQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIALSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSSFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIIASFLMSPPQLRLFQYNYPYWSIILGYAIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP
sequence length 544
structure length 544
publication title Structural basis for recognition of diverse antidepressants by the human serotonin transporter
rcsb
molecule tags Transport protein
molecule keywords Sodium-dependent serotonin transporter
source organism Homo sapiens
ec nomenclature
pdb deposition date2017-09-06
KnotProt deposition date2017-10-25
Image from the rcsb pdb (www.rcsb.org)
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5



Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.2 16-301 286 1-15 312-544 302-311 15 233 slipknot
view details
4.1 15-313 299 1-14 337-544 314-336 14 208 slipknot
view details
4.1 12-341 330 1-11 352-544 342-351 11 193 slipknot
view details
3.2 14-347 334 1-13 365-544 348-364 13 180 slipknot
view details
3.2 19-341 323 1-11, 362-544 12-18, 342-361 11 183 slipknot
view details
3.2 19-361 343 1-13, 365-544 14-18, 362-364 13 180 slipknot
view details
3.2 17-335 319 1-11, 342-544 12-16, 336-341 11 203 slipknot
view details
2.1 43-272 230 1-19, 290-544 20-42, 273-289 19 255 slipknot
view details
2.1 43-370 328 1-21, 407-544 22-42, 371-406 21 138 slipknot
view details
2.1 46-424 379 1-22, 509-544 23-45, 425-508 22 36 slipknot
view details
1.1 37-293 257 1-27, 309-544 28-36, 294-308 27 236 slipknot
view details
1.1 40-258 219 1-28, 273-544 29-39, 259-272 28 272 slipknot
view details
1.1 42-258 217 1-39, 273-544 40-41, 259-272 39 272 slipknot
view details
1.1 45-293 249 1-36, 309-544 37-44, 294-308 36 236 slipknot
view details
2.1 43-289 247 1-31, 294-544 32-42, 290-293 31 251 slipknot
view details
1.1 43-259 217 1-41, 267-544 42-42, 260-266 41 278 slipknot
view details
2.1 44-286 243 1-42, 293-544 43-43, 287-292 42 252 slipknot
4XP9C 4XP1A 4XP4A 4M48A 4XNXA 4XNUA 4XPAA 4XPHA 4XP6A 4XPBA 4XPTA 4XPFA 4XPGA 4XP5A 6AWNA 6AWOA 6AWPA 6AWQA
similar chains in the KnotProt database (40% sequence similarity)
5I6XA 5I71A 5I73A 5I74A 5I75A 5I6ZA
similar chains in the pdb database (40% sequence similarity)

 
            
               
#similar chains in the KnotProt database (40% sequence similarity)
 4XP9 C;  4XP1 A;  4XP4 A;  4M48 A;  4XNX A;  4XNU A;  4XPA A;  4XPH A;  4XP6 A;  4XPB A;  4XPT A;  4XPF A;  4XPG A;  4XP5 A;  6AWN A;  6AWO A;  6AWP A;  6AWQ A; 
               
               
           
#similar chains in the pdb database (40% sequence similarity)
 5I6X A;  5I71 A;  5I73 A;  5I74 A;  5I75 A;  5I6Z A; 
           

KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling