6AWQA

Anomalous chloride signal reveals the position of sertraline complexed with the serotonin transporter at the central site
Slipknot S +31 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 42-276 235 277-544 1-24 25-41 24 267 slipknot
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41 19-305 287 1-18 367-544 306-366 18 178 slipknot
Chain Sequence
GSQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICAQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIALSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSSFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIIASFLMSPPQLRLFQYNYPYWSIILGYAIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 15-301 287 1-14 314-544 302-313 14 231 slipknot
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4.1 16-313 298 1-15 329-544 314-328 15 216 slipknot
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4.1 16-328 313 1-15 339-544 329-338 15 206 slipknot
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4.1 10-338 329 1-9 353-544 339-352 9 192 slipknot
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4.1 16-348 333 1-15 362-544 349-361 15 183 slipknot
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4.1 16-361 346 1-15 365-544 362-364 15 180 slipknot
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3.2 18-348 331 1-15, 362-544 16-17, 349-361 15 183 slipknot
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3.2 24-338 315 1-16, 349-544 17-23, 339-348 16 196 slipknot
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3.2 23-335 313 1-17, 339-544 18-22, 336-338 17 206 slipknot
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1.1 26-287 262 1-20, 297-544 21-25, 288-296 20 248 slipknot
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2.1 43-369 327 1-20, 410-544 21-42, 370-409 20 135 slipknot
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2.1 46-483 438 484-544 1-21 22-45 21 60 slipknot
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2.1 43-272 230 1-27, 288-544 28-42, 273-287 27 257 slipknot
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1.1 42-258 217 1-28, 268-544 29-41, 259-267 28 277 slipknot
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1.1 45-290 246 1-31, 308-544 32-44, 291-307 31 237 slipknot
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1.1 39-267 229 1-32, 273-544 33-38, 268-272 32 272 slipknot
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2.1 42-414 373 1-36, 421-544 37-41, 415-420 36 124 slipknot
publication title Structural basis for recognition of diverse antidepressants by the human serotonin transporter
rcsb
structure length 544
molecule tags Transport protein
source organism Homo sapiens
sequence length 544
molecule keywords Sodium-dependent serotonin transporter
ec nomenclature
pdb deposition date 2017-09-06
KnotProt deposition date 2017-10-25
Image from the rcsb pdb (www.rcsb.org)
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