Found 242 chains in Knotoided chains table. Displaying 151 - 242. Applied filters: Probabilistic

Search results query: topological notation for knotoids: K 2.1

Hide raw data panel
#pdbid|chain|deposition date|is S/K-not|(slip)knot types;
      
  7e3s|A|2022-05-11|K|2.1;
  7e3q|A|2022-05-11|K|2.1;
  7d51|A|2021-11-23|K|2.1;
  7mu3|A|2021-10-05|K|2.1;
  6zr9|A|2021-07-16|K|2.1;
  6yma|A|2020-08-23|K|2.1;
  6ufd|A|2020-08-22|K|2.1;
  6ufc|A|2020-08-22|K|2.1;
  6km6|A|2020-08-20|K|2.1;
  6wq7|A|2020-08-06|K|2.1;
  6wq8|A|2020-08-06|K|2.1;
  6otk|A|2020-08-04|K|2.1;
  6oti|A|2020-08-04|K|2.1;
  6oum|A|2020-08-04|K|2.1;
  6oue|A|2020-08-04|K|2.1;
  6rg3|A|2020-08-04|K|2.1;
  6s03|A|2020-08-04|K|2.1;
  6ux1|A|2020-04-30|K|2.1;
  6r6j|A|2020-04-17|K|2.1;
  6rxz|CN|2020-04-09|K|2.1;
  6qut|A|2020-04-09|K|2.1;
  6i0j|A|2019-11-28|K|2.1;
  6i0l|A|2019-11-28|K|2.1;
  6qfv|A|2019-05-08|K|2.1;
  6qfx|A|2019-05-08|K|2.1;
  6qfu|A|2019-05-08|K|2.1;
  6qfw|A|2019-05-08|K|2.1;
  6qeb|A|2019-03-22|K|2.1;
  6h2z|A|2019-01-09|K|2.1;
  6h34|A|2019-01-09|K|2.1;
  6h33|A|2019-01-09|K|2.1;
  6g3v|A|2018-12-02|K|2.1;
  12ca|A|2018-10-21|K|2.1;
  5e2m|A|2018-10-21|K|2.1;
  6evr|A|2018-10-21|K|2.1;
  1azm|A|2018-10-21|K|2.1;
  1cvb|A|2018-10-20|K|2.1;
  7ca2|A|2018-10-20|K|2.1;
  3mwo|A|2018-10-20|K|2.1;
  1ydd|A|2018-10-20|K|2.1;
  1huh|A|2018-10-20|K|2.1;
  1hug|A|2018-10-20|K|2.1;
  3p44|A|2018-10-20|K|2.1;
  3bl1|A|2018-10-20|K|2.1;
  4g7a|A|2018-10-20|K|2.1;
  3w6i|A|2018-10-20|K|2.1;
  1cve|A|2018-10-20|K|2.1;
  1hcb|A|2018-10-20|K|2.1;
  4mty|A|2018-10-20|K|2.1;
  5tfx|A|2018-10-20|K|2.1;
  4l5v|A|2018-10-20|K|2.1;
  3kkx|A|2018-10-20|K|2.1;
  4pq7|A|2018-10-20|K|2.1;
  1rj5|A|2018-10-20|K|2.1;
  2fw4|A|2018-10-20|K|2.1;
  1bnq|A|2018-10-20|K|2.1;
  2eu3|A|2018-10-20|K|2.1;
  2weh|A|2018-10-20|K|2.1;
  3f4x|A|2018-10-20|K|2.1;
  3ieo|A|2018-10-20|K|2.1;
  4m2w|A|2018-10-20|K|2.1;
  4ywp|A|2018-10-20|K|2.1;
  4q08|A|2018-10-20|K|2.1;
  4xix|A|2018-10-20|K|2.1;
  1j9w|A|2018-10-20|K|2.1;
  5ty1|A|2018-10-20|K|2.1;
  5ehe|A|2018-10-20|K|2.1;
  5ogj|A|2018-10-20|K|2.1;
  4bcw|A|2018-10-20|K|2.1;
  1ccs|A|2018-10-20|K|2.1;
  3t82|A|2018-10-19|K|2.1;
  1uga|A|2018-10-19|K|2.1;
  1fqr|A|2018-10-19|K|2.1;
  3ni5|A|2018-10-19|K|2.1;
  1bnw|A|2018-10-19|K|2.1;
  4e4a|A|2018-10-19|K|2.1;
  5n1s|A|2018-10-19|K|2.1;
  5cac|A|2018-10-19|K|2.1;
  5tya|A|2018-10-19|K|2.1;
  2pov|A|2018-10-19|K|2.1;
  4wl4|A|2018-10-19|K|2.1;
  4ito|A|2018-10-19|K|2.1;
  3v3j|A|2018-10-19|K|2.1;
  4fl7|A|2018-10-19|K|2.1;
  1koq|A|2018-10-19|K|2.1;
  1cvh|A|2018-10-19|K|2.1;
  2it4|A|2018-10-19|K|2.1;
  1g6v|A|2018-10-19|K|2.1;
  1rj6|A|2018-10-19|K|2.1;
  1cct|A|2018-10-19|K|2.1;
  1bnu|A|2018-10-19|K|2.1;
  3m2z|A|2018-10-19|K|2.1;
  6bcc|A|2018-10-19|K|2.1;
  1dcb|A|2018-10-19|K|2.1;
  4frc|A|2018-10-19|K|2.1;
  1oq5|A|2018-10-19|K|2.1;
  4e3d|A|2018-10-19|K|2.1;
  4pxx|A|2018-10-19|K|2.1;
  4r5b|A|2018-10-19|K|2.1;
  3dcs|A|2018-10-19|K|2.1;
  2cab|A|2018-10-19|K|2.1;
  4q6d|A|2018-10-19|K|2.1;
  5u0e|A|2018-10-19|K|2.1;
  1dca|A|2018-10-19|K|2.1;
  4qjx|A|2018-10-18|K|2.1;
  5gmm|A|2018-10-18|K|2.1;
  4yvy|A|2018-10-18|K|2.1;
  5n0d|A|2018-10-18|K|2.1;
  1cva|A|2018-10-18|K|2.1;
  1cil|A|2018-10-18|K|2.1;
  1tg9|A|2018-10-18|K|2.1;
  1hec|A|2018-10-18|K|2.1;
  1cvc|A|2018-10-18|K|2.1;
  1yo1|A|2018-10-18|K|2.1;
  2nxs|A|2018-10-18|K|2.1;
  1ydb|A|2018-10-18|K|2.1;
  2nxr|A|2018-10-18|K|2.1;
  3t84|A|2018-10-18|K|2.1;
  4z1j|A|2018-10-18|K|2.1;
  4y0j|A|2018-10-18|K|2.1;
  1fr7|A|2018-10-18|K|2.1;
  1crm|A|2018-10-18|K|2.1;
  1flj|A|2018-10-18|K|2.1;
  1cnw|A|2018-10-18|K|2.1;
  4q06|A|2018-10-18|K|2.1;
  2nn7|A|2018-10-18|K|2.1;
  3m5s|A|2018-10-18|K|2.1;
  3m1w|A|2018-10-18|K|2.1;
  1cvd|A|2018-10-18|K|2.1;
  6d1m|A|2018-10-18|K|2.1;
  1fsr|A|2018-10-18|K|2.1;
  4m2v|A|2018-10-18|K|2.1;
  4k1q|A|2018-10-18|K|2.1;
  1cny|A|2018-10-18|K|2.1;
  1a42|A|2018-10-18|K|2.1;
  3v3g|B|2018-10-18|K|2.1;
  3hfp|A|2018-10-18|K|2.1;
  1cnc|A|2018-10-18|K|2.1;
  2nwz|A|2018-10-18|K|2.1;
  4hf3|A|2018-10-18|K|2.1;
  3tvo|X|2018-10-18|K|2.1;
  2q38|A|2018-10-18|K|2.1;
  3kig|A|2018-10-18|K|2.1;
  3m2y|A|2018-10-18|K|2.1;
  8ca2|A|2018-10-17|K|2.1;
  3da2|A|2018-10-17|K|2.1;
  4yyt|A|2018-10-17|K|2.1;
  4yxo|A|2018-10-17|K|2.1;
  2h15|A|2018-10-17|K|2.1;
  1cim|A|2018-10-17|K|2.1;
  3mdz|A|2018-10-17|K|2.1;
  4lp6|A|2018-10-17|K|2.1;
  6f3b|A|2018-10-12|K|2.1;
  6ex1|A|2018-10-12|K|2.1;
  6fag|A|2018-10-12|K|2.1;
  4kap|A|2018-10-03|K|2.1;
  4q9y|A|2018-10-03|K|2.1;
  1ca2|A|2018-10-03|K|2.1;
  2nwy|A|2018-10-03|K|2.1;
  1heb|A|2018-10-03|K|2.1;
  1hed|A|2018-10-03|K|2.1;
  1hca|A|2018-10-03|K|2.1;
  2ca2|A|2018-10-03|K|2.1;
  1if5|A|2018-10-03|K|2.1;
  1ydc|A|2018-10-03|K|2.1;
  6ca2|A|2018-10-03|K|2.1;
  2o4z|A|2018-10-02|K|2.1;
  3t85|A|2018-10-02|K|2.1;
  3rz0|B|2018-10-02|K|2.1;
  3b4f|A|2018-10-02|K|2.1;
  3ca2|A|2018-10-02|K|2.1;
  3f8e|A|2018-10-02|K|2.1;
  1yda|A|2018-10-01|K|2.1;
  3ffp|X|2018-10-01|K|2.1;
  3okv|A|2018-10-01|K|2.1;
  3kok|A|2018-10-01|K|2.1;
  1kop|A|2018-09-29|K|2.1;
  5dsn|A|2018-09-26|K|2.1;
  5l6k|A|2018-06-12|K|2.1;
  5llg|A|2018-06-12|K|2.1;
  5lln|A|2018-06-12|K|2.1;
  5nxw|A|2018-06-12|K|2.1;
  9ca2|A|2018-06-12|K|2.1;
  5ipz|A|2018-06-12|K|2.1;
  1cnh|A|2018-06-11|K|2.1;
  1czm|A|2018-06-11|K|2.1;
  1fqm|A|2018-06-11|K|2.1;
  1fsn|A|2018-06-11|K|2.1;
  1lg5|A|2018-06-11|K|2.1;
  1mxc|A|2018-06-11|K|2.1;
  1o90|A|2018-06-11|K|2.1;
  2hfy|A|2018-06-11|K|2.1;
  2obv|A|2018-06-11|K|2.1;
  3caj|A|2018-06-11|K|2.1;
  3d8w|A|2018-06-11|K|2.1;
  3dd8|A|2018-06-11|K|2.1;
  3f7b|A|2018-06-11|K|2.1;
  3f7u|A|2018-06-11|K|2.1;
  3fw3|A|2018-06-11|K|2.1;
  3ibl|A|2018-06-11|K|2.1;
  3iml|A|2018-06-11|K|2.1;
  3jxg|A|2018-06-11|K|2.1;
  3jxh|C|2018-06-11|K|2.1;
  3kld|B|2018-06-11|K|2.1;
  3m2n|A|2018-06-11|K|2.1;
  3m3x|A|2018-06-11|K|2.1;
  3m67|A|2018-06-11|K|2.1;
  3mhl|A|2018-06-11|K|2.1;
  3mho|A|2018-06-11|K|2.1;
  3nk6|A|2018-06-11|K|2.1;
  3po6|A|2018-06-11|K|2.1;
  3pyk|A|2018-06-11|K|2.1;
  3rv2|A|2018-06-11|K|2.1;
  3ryy|A|2018-06-11|K|2.1;
  3rz8|A|2018-06-11|K|2.1;
  3so4|A|2018-06-11|K|2.1;
  3tmj|A|2018-06-11|K|2.1;
  3u47|A|2018-06-11|K|2.1;
  3znc|A|2018-06-11|K|2.1;
  4bf6|A|2018-06-11|K|2.1;
  4etq|C|2018-06-11|K|2.1;
  4gge|A|2018-06-11|K|2.1;
  4ktv|C|2018-06-11|K|2.1;
  4ktv|D|2018-06-11|K|2.1;
  4le5|A|2018-06-11|K|2.1;
  4ndn|B|2018-06-11|K|2.1;
  4ndn|C|2018-06-11|K|2.1;
  5dog|A|2018-06-11|K|2.1;
  5e5r|A|2018-06-11|K|2.1;
  5e5u|A|2018-06-11|K|2.1;
  5g03|A|2018-06-11|K|2.1;
  5jn8|A|2018-06-11|K|2.1;
  5jna|A|2018-06-11|K|2.1;
  5jnc|A|2018-06-11|K|2.1;
  5ku6|A|2018-06-11|K|2.1;
  5sz2|A|2018-06-11|K|2.1;
  5sz3|A|2018-06-11|K|2.1;
  5sz7|A|2018-06-11|K|2.1;
  5thj|A|2018-06-11|K|2.1;
  1znc|A|2018-06-11|K|2.1;
  1bcd|A|2018-06-10|K|2.1;
  1bic|A|2018-06-10|K|2.1;

      
Knotoid types pdb Title
K 2.1 3mdzA Crystal structure of human carbonic anhydrase vii [isoform 1], ca7
K 2.1 4lp6A Crystal structure of human carbonic anhydrase ii in complex with a quinoline oligoamide foldamer
K 2.1 6f3bA Crystal structure of human carbonic anhydrase i in complex with the 1-(2-hydroxy-5-sulfamoylphenyl)-3-[(4-methylphenyl)methyl]urea inhibitor
K 2.1 6ex1A Crystal structure of human carbonic anhydrase i in complex with the 4-[(3s)-3 benzyl-4-(4-sulfamoylbenzoyl)piperazine -1-carbonyl]benzene-1-sulfonamide inhibitor
K 2.1 6fagA Crystal structure of human carbonic anhydrase i in complex with the 1-(2-hydroxy-5-sulfamoylphenyl)-3-(2-methoxyphenyl)urea inhibitor
K 2.1 4kapA The binding of benzoarylsulfonamide ligands to human carbonic anhydrase is insensitive to formal fluorination of the ligand
K 2.1 4q9yA Crystal structure of 3-methylthiophenol bound to human carbonic anhydrase ii
K 2.1 1ca2A Refined structure of human carbonic anhydrase ii at 2.0 angstroms resolution
K 2.1 2nwyA Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase ii
K 2.1 1hebA Structural consequences of hydrophilic amino-acid substitutions in the hydrophobic pocket of human carbonic anhydrase ii
K 2.1 1hedA Structural consequences of hydrophilic amino-acid substitutions in the hydrophobic pocket of human carbonic anhydrase ii
K 2.1 1hcaA Unexpected ph-dependent conformation of his-64, the proton shuttle of carbonic anhydrase ii.
K 2.1 2ca2A Crystallographic studies of inhibitor binding sites in human carbonic anhydrase ii. a pentacoordinated binding of the scn-ion to the zinc at high p*h
K 2.1 1if5A Carbonic anhydrase ii complexed with 2,6-difluorobenzenesulfonamide
K 2.1 1ydcA Structural basis of inhibitor affinity to variants of human carbonic anhydrase ii
K 2.1 6ca2A Engineering the hydrophobic pocket of carbonic anhydrase ii
K 2.1 2o4zA Crystal structure of the carbonic anhydrase ii complexed with hydroxysulfamide inhibitor
K 2.1 3t85A Human carbonic anhydrase ii in complex with acetylated carbohydrate sulfamates
K 2.1 3rz0B Fluoroalkyl and alkyl chains have similar hydrophobicities in binding to the hydrophobic wall of carbonic anhydrase
K 2.1 3b4fA Carbonic anhydrase inhibitors. interaction of 2-(hydrazinocarbonyl)-3-phenyl-1h-indole-5-sulfonamide with twelve mammalian isoforms: kinetic and x-ray crystallographic studies
K 2.1 3ca2A Crystallographic studies of inhibitor binding sites in human carbonic anhydrase ii. a pentacoordinated binding of the scn-ion to the zinc at high p*h
K 2.1 3f8eA Coumarins are a novel class of suicide carbonic anhydrase inhibitors
K 2.1 1ydaA Structural basis of inhibitor affinity to variants of human carbonic anhydrase ii
K 2.1 3ffpX X ray structure of the complex between carbonic anhydrase ii and lc inhibitors
K 2.1 3okvA Human carbonic anhydrase ii a65s, n67q (ca ix mimic) bound with 2-ethylestrone 3-o-sulfamate
K 2.1 3kokA Crystal structure of cobalt (ii) human carbonic anhydrase ii at ph 8.5
K 2.1 1kopA Neisseria gonorrhoeae carbonic anhydrase
K 2.1 5dsnA Structure of co2 released holo-form of human carbonic anhydrase ii with 1 hr warming
K 2.1 5l6kA Crystal structure of human carbonic anhydrase ii in complex with a quinoline oligoamide foldamer
K 2.1 5llgA Crystal structure of human carbonic anhydrase isozyme ii with 4-propylthiobenzenesulfonamide
K 2.1 5llnA Crystal structure of human carbonic anhydrase isozyme xiii with 2,3,5,6-tetrafluoro-4-(propylthio)benzenesulfonamide
K 2.1 5nxwA Carbonic anhydrase ii inhibitor ra9
K 2.1 9ca2A Engineering the hydrophobic pocket of carbonic anhydrase ii
K 2.1
1
5ipzA Crystal structure of human carbonic anhydrase isozyme iv with 5-(2-amino-1,3-thiazol-4-yl)-2-chlorobenzenesulfonamide
K 2.1 1cnhA X-ray crystallographic studies of engineered hydrogen bond networks in a protein-zinc binding site
K 2.1 1czmA Drug-protein interactions: structure of sulfonamide drug complexed with human carbonic anhydrase i
K 2.1 1fqmA X-ray crystal structure of zinc-bound f93i/f95m/w97v carbonic anhydrase (caii) variant
K 2.1 1fsnA X-ray crystal structure of metal-free f93s/f95l/w97m carbonic anhydrase (caii) variant
K 2.1 1lg5A Crystal structure analysis of the hca ii mutant t199p in complex with beta-mercaptoethanol
K 2.1
2
1mxcA S-adenosylmethionine synthetase with 8-br-adp
K 2.1
7
1o90A Methionine adenosyltransferase complexed with a l-methionine analogous
K 2.1 2hfyA Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase iii
K 2.1 2obvA Crystal structure of the human s-adenosylmethionine synthetase 1 in complex with the product
K 2.1 3cajA Crystal structure of the human carbonic anhydrase ii in complex with ethoxzolamide
K 2.1 3d8wA Use of a carbonic anhydrase ii, ix active-site mimic, for the purpose of screening inhibitors for possible anti-cancer properties
K 2.1 3dd8A Carbonic anhydrase inhibitors. interaction of the antitumor sulfamate emd-486019 with twelve mammalian isoforms: kinetic and x-ray crystallographic studies
K 2.1
1
3f7bA Crystal structure of soluble domain of ca4 in complex with small molecule.
K 2.1
1
3f7uA Crystal structure of soluble domain of ca4 in complex with small molecule.
K 2.1
2
3fw3A Crystal structure of soluble domain of ca4 in complex with dorzolamide
K 2.1 3iblA The crystal structure of the human carbonic anhydrase ii in complex with an aliphatic bis-sulfamate inhibitor
K 2.1
5
3imlA Crystal structure of s-adenosylmethionine synthetase from burkholderia pseudomallei
K 2.1
1
3jxgA Ca-like domain of mouse ptprg
K 2.1
2
3jxhC Ca-like domain of human ptprg
K 2.1
1
3kldB Ptprg cntn4 complex
K 2.1 3m2nA Crystal structure of human carbonic anhydrase isozyme ii with 4-{2-[n-(6-chloro-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide
K 2.1 3m3xA Crystal structure of human carbonic anhydrase isozyme ii with 4-{2-[n-(6-methoxy-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide
K 2.1 3m67A Crystal structure of human carbonic anhydrase isozyme ii with 2-chloro-5-[(6,7-dihydro-1h-[1,4]dioxino[2,3-f]benzimidazol-2-ylsulfanyl)acetyl]benzenesulfonamide
K 2.1 3mhlA Crystal structure of human carbonic anhydrase isozyme ii with 4-{[n-(6-methoxy-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide
K 2.1 3mhoA Crystal structure of human carbonic anhydrase isozyme ii with 4-[n-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]benzenesulfonamide
K 2.1 3nk6A Structure of the nosiheptide-resistance methyltransferase
K 2.1 3po6A Crystal structure of human carbonic anhydrase ii with 6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1h)-sulfonamide
K 2.1 3pykA Human carbonic anhydrase ii as host for pianostool complexes bearing a sulfonamide anchor
K 2.1
3
3rv2A Crystal structure of s-adenosylmethionine synthetase from mycobacterium marinum
K 2.1 3ryyA Fluoroalkyl and alkyl chains have similar hydrophobicities in binding to the hydrophobic wall of carbonic anhydrase
K 2.1 3rz8A Fluoroalkyl and alkyl chains have similar hydrophobicities in binding to the hydrophobic wall of carbonic anhydrase
K 2.1
3
3so4A Methionine-adenosyltransferase from entamoeba histolytica
K 2.1 3tmjA Joint x-ray/neutron structure of human carbonic anhydrase ii at ph 7.8
K 2.1 3u47A Human carbonic anhydrase ii v143l
K 2.1
1
3zncA Murine carbonic anhydrase iv complexed with brinzolamide
K 2.1 4bf6A Three dimensional structure of human carbonic anhydrase ii in complex with 5-(1-(3-cyanophenyl)-1h-1,2,3-triazol-4-yl)thiophene-2- sulfonamide
K 2.1
1
4etqC Vaccinia virus d8l imv envelope protein in complex with fab of murine igg2a la5
K 2.1 4ggeA Crystal structure of human carbonic anhydrase ii (hcaii) bound with cyanate
K 2.1
5
4ktvC Structural insights of mat enzymes: mata2b complexed with adenosine and pyrophosphate
K 2.1 4ktvD Structural insights of mat enzymes: mata2b complexed with adenosine and pyrophosphate
K 2.1
3
4le5A Structure of an unusual s-adenosylmethionine synthetase from campylobacter jejuni
K 2.1 4ndnB Structural insights of mat enzymes: mata2b complexed with sam and ppnp
K 2.1
2
4ndnC Structural insights of mat enzymes: mata2b complexed with sam and ppnp
K 2.1 5dogA Crystal structure of human carbonic anhydrase isozyme ii with 2-(benzylamino)-3,5,6-trifluoro-4-[(2-phenylethyl)thio]benzene- sulfonamide
K 2.1
1
5e5rA Crystal structure of the complex between carbonic anhydrase-like domain of ptprg and immunoglobulin domains 2-3 of cntn3
K 2.1 5e5uA Crystal structure of the complex between carbonic anhydrase-like domain of ptprg and immunoglobulin domains 2-3 of cntn6
K 2.1 5g03A An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of psammaplin c
K 2.1
1
5jn8A Crystal structure for the complex of human carbonic anhydrase iv and acetazolamide
K 2.1
1
5jnaA Crystal structure for the complex of human carbonic anhydrase iv and topiramate
K 2.1
1
5jncA Crystal structure for the complex of human carbonic anhydrase iv and 4-aminomethylbenzene sulfonamide
K 2.1
1
5ku6A Crystal structure for the complex of human carbonic anhydrase iv and methazolamide
K 2.1 5sz2A Carbonic anhydrase ii in complex with 4-(3-formylphenyl)-benzenesulfonamide
K 2.1 5sz3A Carbonic anhydrase ii in complex with 4-(3-quinolinyl)-benzenesulfonamide
K 2.1 5sz7A Carbonic anhydrase ix-mimic in complex with 4-(3-quinolinyl)-benzenesulfonamide
K 2.1 5thjA Crystal structure of 2-hydroxycyclohepta-2,4,6-trien-1-one bound to human carbonic anhydrase 2
K 2.1 1zncA Human carbonic anhydrase iv
K 2.1 1bcdA X-ray crystallographic structure of a complex between human carbonic anhydrase ii and a new topical inhibitor, trifluoromethane sulphonamide
K 2.1 1bicA Crystallographic analysis of thr-200-> his human carbonic anhydrase ii and its complex with the substrate, hco3-

KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling