1EKUA

Crystal structure of a biologically active single chain mutant of human ifn-gamma
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 47-260 214 1-46, 261-263 46 3 knot
Chain Sequence
MQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIDELIQVMAEFSTEEQQEGPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIHELIQVMAELSP-----------MLF
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
missing residues 250-260
publication title Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma.
pubmed doi rcsb
structure length 252
molecule tags Immune system
source organism Homo sapiens
sequence length 263
total genus Genus: 94
molecule keywords INTERFERON GAMMA
ec nomenclature
pdb deposition date 2000-03-09
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00714 IFN-gamma Interferon gamma
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.10 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 1ekuA01
1.20.1250.10 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 1ekuA02
1EKUA
chains in the KnotProt database with same CATH superfamily
1EKUA
chains in the KnotProt database with same CATH topology
1EKUA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1EKU A; 
#chains in the KnotProt database with same CATH topology
 1EKU A; 
#chains in the KnotProt database with same CATH homology
 1EKU A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling