3S9MC

Complex between transferrin receptor 1 and transferrin with iron in the n-lobe, cryocooled 1
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 2x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 19-161 143 1-18, 162-220 18 58 slipknot
Fingerprint Knot forming loop Loop type
K +31 Asp63 ... Cys137 <-> Cys331 ... Tyr188 <->
Bridging ionFe901
<-> Asp63
ion-based
K +31 Asp63 ... Cys137 <-> Cys331 ... Cys241 <-> Cys227 ... Tyr188 <->
Bridging ionFe901
<-> Asp63
ion-based
Chain Sequence
KTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVKKASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTCPEAPTDECKPVKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGKCGLVPVLAENYDKSDNCEDTPEAG-------------------------------------------------------------------------------------------------------------------------------------------------------------PNHAVVTRKDKEACVHKILRQQQHLFGSDVTDCSGNFCLFRSETKDLLFRDDTVCLAKLHDRNTYEKYLGEEYVKAVGNLRKCSTSSLLEACTFR
sequence length 674
structure length 517
publication title How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Transferrin receptor protein 1
source organism Homo sapiens
missing residues 423-579
total genus Genus: 114
ec nomenclature
pdb deposition date 2011-06-01
KnotProt deposition date 2018-11-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00405 Transferrin Transferrin
Image from the rcsb pdb (www.rcsb.org)
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