1FLTW

Vegf in complex with domain 2 of the flt-1 receptor
Cysteine knot

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Loop Piercing
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57-c-61-b-104-c-102 26-b-68
Chain Sequence
HEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKD
sequence length 98
structure length 98
publication title Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.
pubmed doi rcsb
molecule tags Complex (growth factor/transferase)
molecule keywords VASCULAR ENDOTHELIAL GROWTH FACTOR
source organism Homo sapiens
ec nomenclature
pdb deposition date 1997-11-20
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 1fltW00
1FL7C 1TZHV 1KATV 1ES7A 1QTYW 2GYRF 3QTKF 2QR0C 3B4VF 3BMPA 1AGQB 3FUBD 1XWDD 2GOOA 1VPPV 2XV7A 1AGQC 1ES7C 1NYSB 1RV6V 1CZ8V 1FL7A 2H62A 1FZVA 1KLAA 1QTYV 2FJGW 3KFDA 1KTZA 2QCWA 2VPFG 2GYRD 1QTYS 2VPFC 1FZVB 1TGJA 1REWA 1BMPA 2GNNC 1KLAB 3EVSB 3KFDB 1S4YD 3MJGA 3KFDD 2QCWB 1SGFB 2ARVA 3QTKC 3KFDC 1BJ1W 1BNDA 1FLTV 1REWB 2P6AA 3EO1C 1M4UL 2QCQA 3MJGB 2ARVB 2FJGV 2VPFA 1B98A 1HRPA 1WQ9A 1BNDB 1FLTW 2GNNA 2P6AB 1LX5A 1PDGB 1HCNA 2C7WB 2QCQB 2QR0U 2GYRA 1PDGC 3BK3B 3QTKA 1VPFD 2QJBA 2VPFB 2X1WD 1HRPB 1KLCA 1WQ9B 2V5EB 3B4VA 3EO1I 2R53A 1ZKZA 2GNNB 2GH0D 1B8MA 1LXIA 1BJ1V 1HCNB 2H64A 1BTGB 2GYRB 3QTKB 1WQ8A 2QJBB 1XWDA 3B4VB 1KLCB 2GYRC 2R53B 2GOOD 2XACB 1REUA 2VPFE 2QR0J 3BDYV 1S4YB 1TFGA 1QFWA 1PDGA 2QR0P 2QR0V 1NYUD 2PJYA 2TGIA 2C7WA 3FUBB 1XWDB 2QJ9B 3BK3A 2ASKA 3HH2A 1AOCA 1FL7D 2GYRE 3QTKE 1E9JA 2GYZA 2VWEA 3B4VE 1QFWB 2VPFF 1VPFA 2QR0D 1MJVA 3HH2B 2QJAA 1AOCB 2ASKB 1XWDE 1AGQD 2VPFH 1NT3A 2VWEB 2XACA 1SGFY 1VPFB 1MJVB 2FJHW 2X1WB 2QJAB 1TZHW 1VPFC 2R52A 2X1WC 1KATW 1TGKA 2QJ9A 2B0UA 2GH0C 2BHKA 2ARPA 1VPPW 2QR0O 2R52B 2VPFD 2X1XE 3EO1L 2B0UB 2QR0I 1NYUB 2GNND 1DZ7A 1QTYR 1HD4A 1RV6W 1CZ8W 1FL7B 1TZIV 2X1WA 3QTKD 2FJHV 2H62B 1AGQA 1WAQA
chains in the KnotProt database with same CATH superfamily
1FL7C 1TZHV 1KATV 1ES7A 1QTYW 2GYRF 3QTKF 2QR0C 3B4VF 3BMPA 1AGQB 3FUBD 1XWDD 2GOOA 1VPPV 2XV7A 1AGQC 1ES7C 1NYSB 1RV6V 1CZ8V 1FL7A 2H62A 1FZVA 1KLAA 1QTYV 2FJGW 3KFDA 1KTZA 2QCWA 2VPFG 2GYRD 1QTYS 2VPFC 1FZVB 1TGJA 1REWA 1BMPA 2GNNC 1KLAB 3EVSB 3KFDB 1S4YD 3MJGA 3KFDD 2QCWB 1SGFB 2ARVA 3QTKC 3KFDC 1BJ1W 1BNDA 1FLTV 1REWB 2P6AA 3EO1C 1M4UL 2QCQA 3MJGB 2ARVB 2FJGV 2VPFA 1B98A 1HRPA 1WQ9A 1BNDB 1FLTW 2GNNA 2P6AB 1LX5A 1PDGB 1HCNA 2C7WB 2QCQB 2QR0U 2GYRA 1PDGC 3BK3B 3QTKA 1VPFD 2QJBA 2VPFB 2X1WD 1HRPB 1KLCA 1WQ9B 2V5EB 3B4VA 3EO1I 2R53A 1ZKZA 2GNNB 2GH0D 1B8MA 1LXIA 1BJ1V 1HCNB 2H64A 1BTGB 2GYRB 3QTKB 1WQ8A 2QJBB 1XWDA 3B4VB 1KLCB 2GYRC 2R53B 2GOOD 2XACB 1REUA 2VPFE 2QR0J 3BDYV 1S4YB 1TFGA 1QFWA 1PDGA 2QR0P 2QR0V 1NYUD 2PJYA 2TGIA 2C7WA 3FUBB 1XWDB 2QJ9B 3BK3A 2ASKA 3HH2A 1AOCA 1FL7D 2GYRE 3QTKE 1E9JA 2GYZA 2VWEA 3B4VE 1QFWB 2VPFF 1VPFA 2QR0D 1MJVA 3HH2B 2QJAA 1AOCB 2ASKB 1XWDE 1AGQD 2VPFH 1NT3A 2VWEB 2XACA 1SGFY 1VPFB 1MJVB 2FJHW 2X1WB 2QJAB 1TZHW 1VPFC 2R52A 2X1WC 1KATW 1TGKA 2QJ9A 2B0UA 2GH0C 2BHKA 2ARPA 1VPPW 2QR0O 2R52B 2VPFD 2X1XE 3EO1L 2B0UB 2QR0I 1NYUB 2GNND 1DZ7A 1QTYR 1HD4A 1RV6W 1CZ8W 1FL7B 1TZIV 2X1WA 3QTKD 2FJHV 2H62B 1AGQA 1WAQA
chains in the KnotProt database with same CATH topology
1FL7C 1TZHV 1KATV 1ES7A 1QTYW 2GYRF 3QTKF 2QR0C 3B4VF 3BMPA 1AGQB 3FUBD 1XWDD 2GOOA 1VPPV 2XV7A 1AGQC 1ES7C 1NYSB 1RV6V 1CZ8V 1FL7A 2H62A 1FZVA 1KLAA 1QTYV 2FJGW 3KFDA 1KTZA 2QCWA 2VPFG 2GYRD 1QTYS 2VPFC 1FZVB 1TGJA 1REWA 1BMPA 2GNNC 1KLAB 3EVSB 3KFDB 1S4YD 3MJGA 3KFDD 2QCWB 1SGFB 2ARVA 3QTKC 3KFDC 1BJ1W 1BNDA 1FLTV 1REWB 2P6AA 3EO1C 1M4UL 2QCQA 3MJGB 2ARVB 2FJGV 2VPFA 1B98A 1HRPA 1WQ9A 1BNDB 1FLTW 2GNNA 2P6AB 1LX5A 1PDGB 1HCNA 2C7WB 2QCQB 2QR0U 2GYRA 1PDGC 3BK3B 3QTKA 1VPFD 2QJBA 2VPFB 2X1WD 1HRPB 1KLCA 1WQ9B 2V5EB 3B4VA 3EO1I 2R53A 1ZKZA 2GNNB 2GH0D 1B8MA 1LXIA 1BJ1V 1HCNB 2H64A 1BTGB 2GYRB 3QTKB 1WQ8A 2QJBB 1XWDA 3B4VB 1KLCB 2GYRC 2R53B 2GOOD 2XACB 1REUA 2VPFE 2QR0J 3BDYV 1S4YB 1TFGA 1QFWA 1PDGA 2QR0P 2QR0V 1NYUD 2PJYA 2TGIA 2C7WA 3FUBB 1XWDB 2QJ9B 3BK3A 2ASKA 3HH2A 1AOCA 1FL7D 2GYRE 3QTKE 1E9JA 2GYZA 2VWEA 3B4VE 1QFWB 2VPFF 1VPFA 2QR0D 1MJVA 3HH2B 2QJAA 1AOCB 2ASKB 1XWDE 1AGQD 2VPFH 1NT3A 2VWEB 2XACA 1SGFY 1VPFB 1MJVB 2FJHW 2X1WB 2QJAB 1TZHW 1VPFC 2R52A 2X1WC 1KATW 1TGKA 2QJ9A 2B0UA 2GH0C 2BHKA 2ARPA 1VPPW 2QR0O 2R52B 2VPFD 2X1XE 3EO1L 2B0UB 2QR0I 1NYUB 2GNND 1DZ7A 1QTYR 1HD4A 1RV6W 1CZ8W 1FL7B 1TZIV 2X1WA 3QTKD 2FJHV 2H62B 1AGQA 1WAQA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1FL7 C;  1TZH V;  1KAT V;  1ES7 A;  1QTY W;  2GYR F;  3QTK F;  2QR0 C;  3B4V F;  3BMP A;  1AGQ B;  3FUB D;  1XWD D;  2GOO A;  1VPP V;  2XV7 A;  1AGQ C;  1ES7 C;  1NYS B;  1RV6 V;  1CZ8 V;  1FL7 A;  2H62 A;  1FZV A;  1KLA A;  1QTY V;  2FJG W;  3KFD A;  1KTZ A;  2QCW A;  2VPF G;  2GYR D;  1QTY S;  2VPF C;  1FZV B;  1TGJ A;  1REW A;  1BMP A;  2GNN C;  1KLA B;  3EVS B;  3KFD B;  1S4Y D;  3MJG A;  3KFD D;  2QCW B;  1SGF B;  2ARV A;  3QTK C;  3KFD C;  1BJ1 W;  1BND A;  1FLT V;  1REW B;  2P6A A;  3EO1 C;  1M4U L;  2QCQ A;  3MJG B;  2ARV B;  2FJG V;  2VPF A;  1B98 A;  1HRP A;  1WQ9 A;  1BND B;  1FLT W;  2GNN A;  2P6A B;  1LX5 A;  1PDG B;  1HCN A;  2C7W B;  2QCQ B;  2QR0 U;  2GYR A;  1PDG C;  3BK3 B;  3QTK A;  1VPF D;  2QJB A;  2VPF B;  2X1W D;  1HRP B;  1KLC A;  1WQ9 B;  2V5E B;  3B4V A;  3EO1 I;  2R53 A;  1ZKZ A;  2GNN B;  2GH0 D;  1B8M A;  1LXI A;  1BJ1 V;  1HCN B;  2H64 A;  1BTG B;  2GYR B;  3QTK B;  1WQ8 A;  2QJB B;  1XWD A;  3B4V B;  1KLC B;  2GYR C;  2R53 B;  2GOO D;  2XAC B;  1REU A;  2VPF E;  2QR0 J;  3BDY V;  1S4Y B;  1TFG A;  1QFW A;  1PDG A;  2QR0 P;  2QR0 V;  1NYU D;  2PJY A;  2TGI A;  2C7W A;  3FUB B;  1XWD B;  2QJ9 B;  3BK3 A;  2ASK A;  3HH2 A;  1AOC A;  1FL7 D;  2GYR E;  3QTK E;  1E9J A;  2GYZ A;  2VWE A;  3B4V E;  1QFW B;  2VPF F;  1VPF A;  2QR0 D;  1MJV A;  3HH2 B;  2QJA A;  1AOC B;  2ASK B;  1XWD E;  1AGQ D;  2VPF H;  1NT3 A;  2VWE B;  2XAC A;  1SGF Y;  1VPF B;  1MJV B;  2FJH W;  2X1W B;  2QJA B;  1TZH W;  1VPF C;  2R52 A;  2X1W C;  1KAT W;  1TGK A;  2QJ9 A;  2B0U A;  2GH0 C;  2BHK A;  2ARP A;  1VPP W;  2QR0 O;  2R52 B;  2VPF D;  2X1X E;  3EO1 L;  2B0U B;  2QR0 I;  1NYU B;  2GNN D;  1DZ7 A;  1QTY R;  1HD4 A;  1RV6 W;  1CZ8 W;  1FL7 B;  1TZI V;  2X1W A;  3QTK D;  2FJH V;  2H62 B;  1AGQ A;  1WAQ A; 
#chains in the KnotProt database with same CATH topology
 1FL7 C;  1TZH V;  1KAT V;  1ES7 A;  1QTY W;  2GYR F;  3QTK F;  2QR0 C;  3B4V F;  3BMP A;  1AGQ B;  3FUB D;  1XWD D;  2GOO A;  1VPP V;  2XV7 A;  1AGQ C;  1ES7 C;  1NYS B;  1RV6 V;  1CZ8 V;  1FL7 A;  2H62 A;  1FZV A;  1KLA A;  1QTY V;  2FJG W;  3KFD A;  1KTZ A;  2QCW A;  2VPF G;  2GYR D;  1QTY S;  2VPF C;  1FZV B;  1TGJ A;  1REW A;  1BMP A;  2GNN C;  1KLA B;  3EVS B;  3KFD B;  1S4Y D;  3MJG A;  3KFD D;  2QCW B;  1SGF B;  2ARV A;  3QTK C;  3KFD C;  1BJ1 W;  1BND A;  1FLT V;  1REW B;  2P6A A;  3EO1 C;  1M4U L;  2QCQ A;  3MJG B;  2ARV B;  2FJG V;  2VPF A;  1B98 A;  1HRP A;  1WQ9 A;  1BND B;  1FLT W;  2GNN A;  2P6A B;  1LX5 A;  1PDG B;  1HCN A;  2C7W B;  2QCQ B;  2QR0 U;  2GYR A;  1PDG C;  3BK3 B;  3QTK A;  1VPF D;  2QJB A;  2VPF B;  2X1W D;  1HRP B;  1KLC A;  1WQ9 B;  2V5E B;  3B4V A;  3EO1 I;  2R53 A;  1ZKZ A;  2GNN B;  2GH0 D;  1B8M A;  1LXI A;  1BJ1 V;  1HCN B;  2H64 A;  1BTG B;  2GYR B;  3QTK B;  1WQ8 A;  2QJB B;  1XWD A;  3B4V B;  1KLC B;  2GYR C;  2R53 B;  2GOO D;  2XAC B;  1REU A;  2VPF E;  2QR0 J;  3BDY V;  1S4Y B;  1TFG A;  1QFW A;  1PDG A;  2QR0 P;  2QR0 V;  1NYU D;  2PJY A;  2TGI A;  2C7W A;  3FUB B;  1XWD B;  2QJ9 B;  3BK3 A;  2ASK A;  3HH2 A;  1AOC A;  1FL7 D;  2GYR E;  3QTK E;  1E9J A;  2GYZ A;  2VWE A;  3B4V E;  1QFW B;  2VPF F;  1VPF A;  2QR0 D;  1MJV A;  3HH2 B;  2QJA A;  1AOC B;  2ASK B;  1XWD E;  1AGQ D;  2VPF H;  1NT3 A;  2VWE B;  2XAC A;  1SGF Y;  1VPF B;  1MJV B;  2FJH W;  2X1W B;  2QJA B;  1TZH W;  1VPF C;  2R52 A;  2X1W C;  1KAT W;  1TGK A;  2QJ9 A;  2B0U A;  2GH0 C;  2BHK A;  2ARP A;  1VPP W;  2QR0 O;  2R52 B;  2VPF D;  2X1X E;  3EO1 L;  2B0U B;  2QR0 I;  1NYU B;  2GNN D;  1DZ7 A;  1QTY R;  1HD4 A;  1RV6 W;  1CZ8 W;  1FL7 B;  1TZI V;  2X1W A;  3QTK D;  2FJH V;  2H62 B;  1AGQ A;  1WAQ A; 
#chains in the KnotProt database with same CATH homology
 1FL7 C;  1TZH V;  1KAT V;  1ES7 A;  1QTY W;  2GYR F;  3QTK F;  2QR0 C;  3B4V F;  3BMP A;  1AGQ B;  3FUB D;  1XWD D;  2GOO A;  1VPP V;  2XV7 A;  1AGQ C;  1ES7 C;  1NYS B;  1RV6 V;  1CZ8 V;  1FL7 A;  2H62 A;  1FZV A;  1KLA A;  1QTY V;  2FJG W;  3KFD A;  1KTZ A;  2QCW A;  2VPF G;  2GYR D;  1QTY S;  2VPF C;  1FZV B;  1TGJ A;  1REW A;  1BMP A;  2GNN C;  1KLA B;  3EVS B;  3KFD B;  1S4Y D;  3MJG A;  3KFD D;  2QCW B;  1SGF B;  2ARV A;  3QTK C;  3KFD C;  1BJ1 W;  1BND A;  1FLT V;  1REW B;  2P6A A;  3EO1 C;  1M4U L;  2QCQ A;  3MJG B;  2ARV B;  2FJG V;  2VPF A;  1B98 A;  1HRP A;  1WQ9 A;  1BND B;  1FLT W;  2GNN A;  2P6A B;  1LX5 A;  1PDG B;  1HCN A;  2C7W B;  2QCQ B;  2QR0 U;  2GYR A;  1PDG C;  3BK3 B;  3QTK A;  1VPF D;  2QJB A;  2VPF B;  2X1W D;  1HRP B;  1KLC A;  1WQ9 B;  2V5E B;  3B4V A;  3EO1 I;  2R53 A;  1ZKZ A;  2GNN B;  2GH0 D;  1B8M A;  1LXI A;  1BJ1 V;  1HCN B;  2H64 A;  1BTG B;  2GYR B;  3QTK B;  1WQ8 A;  2QJB B;  1XWD A;  3B4V B;  1KLC B;  2GYR C;  2R53 B;  2GOO D;  2XAC B;  1REU A;  2VPF E;  2QR0 J;  3BDY V;  1S4Y B;  1TFG A;  1QFW A;  1PDG A;  2QR0 P;  2QR0 V;  1NYU D;  2PJY A;  2TGI A;  2C7W A;  3FUB B;  1XWD B;  2QJ9 B;  3BK3 A;  2ASK A;  3HH2 A;  1AOC A;  1FL7 D;  2GYR E;  3QTK E;  1E9J A;  2GYZ A;  2VWE A;  3B4V E;  1QFW B;  2VPF F;  1VPF A;  2QR0 D;  1MJV A;  3HH2 B;  2QJA A;  1AOC B;  2ASK B;  1XWD E;  1AGQ D;  2VPF H;  1NT3 A;  2VWE B;  2XAC A;  1SGF Y;  1VPF B;  1MJV B;  2FJH W;  2X1W B;  2QJA B;  1TZH W;  1VPF C;  2R52 A;  2X1W C;  1KAT W;  1TGK A;  2QJ9 A;  2B0U A;  2GH0 C;  2BHK A;  2ARP A;  1VPP W;  2QR0 O;  2R52 B;  2VPF D;  2X1X E;  3EO1 L;  2B0U B;  2QR0 I;  1NYU B;  2GNN D;  1DZ7 A;  1QTY R;  1HD4 A;  1RV6 W;  1CZ8 W;  1FL7 B;  1TZI V;  2X1W A;  3QTK D;  2FJH V;  2H62 B;  1AGQ A;  1WAQ A;
1FLTV 1KATV 1QTYR 1TZHV 1TZIV 1VPFA 1VPPV 2FJGV 2FJHV
similar chains in the KnotProt database (40% sequence similarity)
None
similar chains in the pdb database (40% sequence similarity)

  
#similar chains in the KnotProt database (40% sequence similarity)
1FLT V; 1KAT V; 1QTY R; 1TZH V; 1TZI V; 1VPF A; 1VPP V; 2FJG V; 2FJH V; 
#similar chains, but unknotted

#similar chains in the pdb database (40% sequence similarity)
How to cite
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