1TFG | KnotProt

Cysteine knot

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Help Cysteine knot data interpretation Full screen

				Loop	Piercing
view details				44-c-48-b-111-c-109	15-b-78

Chain Sequence

ALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS

sequence length	112
structure length	112
publication title	An unusual feature revealed by the crystal structure at 2.2 A resolution of human transforming growth factor-beta 2. pubmed doi rcsb
molecule tags	Growth factor
molecule keywords	TRANSFORMING GROWTH FACTOR, BETA 2
source organism	Homo sapiens
ec nomenclature
pdb deposition date	1992-11-17

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	1tfgA00

1KLCA 1LX5A 1QTYV 2GYRA 1KATW 2QCQA 2X1WD 2GH0D 3B4VE 2QCWB 1TZHW 2VPFG 1HD4A 2GNNB 2H62B 1BJ1V 1HRPA 2QR0J 2QR0P 1AOCA 1VPPV 1WQ8A 2QCWA 1QFWB 2GNNA 1PDGC 1REWB 1VPFC 3MJGB 1PDGB 1FL7B 3HH2B 2QJAA 1VPFB 2PJYA 1QFWA 2QR0C 1REUA 1WAQA 1FLTV 2FJHV 1REWA 1S4YD 2R53B 2QR0I 2QJAB 1PDGA 1FL7A 2XV7A 3HH2A 3MJGA 1VPFA 2QJ9A 1RV6V 2GYRD 1TGJA 2VPFD 1NYUB 2VPFH 2FJGV 3KFDC 1QTYR 2ARVB 2GYRB 1CZ8W 1SGFB 2R53A 2V5EB 2VPFB 3EO1C 1KTZA 1DZ7A 1AGQC 2QJBB 2X1XE 3EVSB 2BHKA 2FJGW 2ARVA 1TZHV 3EO1I 2VPFA 1HRPB 2QJBA 3KFDA 1AOCB 2GYRF 2VPFF 2ARPA 2GNND 2QR0U 1WQ9A 2VWEB 1BNDB 1ZKZA 1B98A 2VWEA 2R52B 1ES7C 1BNDA 1FL7D 2B0UB 1VPFD 2GYRE 3QTKC 2VPFE 2QJ9B 1FZVA 2R52A 2B0UA 3EO1L 1CZ8V 2C7WA 1NYUD 2QR0O 3QTKA 1BTGB 3BDYV 3KFDD 1NT3A 3BMPA 3KFDB 1AGQD 2X1WC 1AGQB 2QR0V 1BMPA 1AGQA 1XWDB 2GOOA 1NYSB 1XWDA 1FZVB 1M4UL 3QTKD 1SGFY 2C7WB 3BK3B 2QR0D 2QCQB 3QTKB 2GYZA 1B8MA 1ES7A 2XACB 3BK3A 1QTYS 1LXIA 1TFGA 1HCNB 1XWDE 3QTKF 2XACA 2ASKB 1QTYW 2GOOD 2GNNC 2GH0C 1TGKA 2X1WB 1HCNA 2ASKA 1XWDD 1MJVB 2X1WA 3FUBD 2H62A 1BJ1W 3QTKE 1E9JA 1VPPW 1FL7C 3FUBB 1MJVA 3B4VB 2P6AB 3B4VA 1KLAB 1WQ9B 1S4YB 2TGIA 3B4VF 1KLCB 1FLTW 2FJHW 2GYRC 2P6AA 2VPFC 1TZIV 2H64A 1KLAA 1KATV 1RV6W
chains in the KnotProt database with same CATH superfamily

#chains in the KnotProt database with same CATH superfamily
 1KLC A;  1LX5 A;  1QTY V;  2GYR A;  1KAT W;  2QCQ A;  2X1W D;  2GH0 D;  3B4V E;  2QCW B;  1TZH W;  2VPF G;  1HD4 A;  2GNN B;  2H62 B;  1BJ1 V;  1HRP A;  2QR0 J;  2QR0 P;  1AOC A;  1VPP V;  1WQ8 A;  2QCW A;  1QFW B;  2GNN A;  1PDG C;  1REW B;  1VPF C;  3MJG B;  1PDG B;  1FL7 B;  3HH2 B;  2QJA A;  1VPF B;  2PJY A;  1QFW A;  2QR0 C;  1REU A;  1WAQ A;  1FLT V;  2FJH V;  1REW A;  1S4Y D;  2R53 B;  2QR0 I;  2QJA B;  1PDG A;  1FL7 A;  2XV7 A;  3HH2 A;  3MJG A;  1VPF A;  2QJ9 A;  1RV6 V;  2GYR D;  1TGJ A;  2VPF D;  1NYU B;  2VPF H;  2FJG V;  3KFD C;  1QTY R;  2ARV B;  2GYR B;  1CZ8 W;  1SGF B;  2R53 A;  2V5E B;  2VPF B;  3EO1 C;  1KTZ A;  1DZ7 A;  1AGQ C;  2QJB B;  2X1X E;  3EVS B;  2BHK A;  2FJG W;  2ARV A;  1TZH V;  3EO1 I;  2VPF A;  1HRP B;  2QJB A;  3KFD A;  1AOC B;  2GYR F;  2VPF F;  2ARP A;  2GNN D;  2QR0 U;  1WQ9 A;  2VWE B;  1BND B;  1ZKZ A;  1B98 A;  2VWE A;  2R52 B;  1ES7 C;  1BND A;  1FL7 D;  2B0U B;  1VPF D;  2GYR E;  3QTK C;  2VPF E;  2QJ9 B;  1FZV A;  2R52 A;  2B0U A;  3EO1 L;  1CZ8 V;  2C7W A;  1NYU D;  2QR0 O;  3QTK A;  1BTG B;  3BDY V;  3KFD D;  1NT3 A;  3BMP A;  3KFD B;  1AGQ D;  2X1W C;  1AGQ B;  2QR0 V;  1BMP A;  1AGQ A;  1XWD B;  2GOO A;  1NYS B;  1XWD A;  1FZV B;  1M4U L;  3QTK D;  1SGF Y;  2C7W B;  3BK3 B;  2QR0 D;  2QCQ B;  3QTK B;  2GYZ A;  1B8M A;  1ES7 A;  2XAC B;  3BK3 A;  1QTY S;  1LXI A;  1TFG A;  1HCN B;  1XWD E;  3QTK F;  2XAC A;  2ASK B;  1QTY W;  2GOO D;  2GNN C;  2GH0 C;  1TGK A;  2X1W B;  1HCN A;  2ASK A;  1XWD D;  1MJV B;  2X1W A;  3FUB D;  2H62 A;  1BJ1 W;  3QTK E;  1E9J A;  1VPP W;  1FL7 C;  3FUB B;  1MJV A;  3B4V B;  2P6A B;  3B4V A;  1KLA B;  1WQ9 B;  1S4Y B;  2TGI A;  3B4V F;  1KLC B;  1FLT W;  2FJH W;  2GYR C;  2P6A A;  2VPF C;  1TZI V;  2H64 A;  1KLA A;  1KAT V;  1RV6 W; 
#chains in the KnotProt database with same CATH topology
 1KLC A;  1LX5 A;  1QTY V;  2GYR A;  1KAT W;  2QCQ A;  2X1W D;  2GH0 D;  3B4V E;  2QCW B;  1TZH W;  2VPF G;  1HD4 A;  2GNN B;  2H62 B;  1BJ1 V;  1HRP A;  2QR0 J;  2QR0 P;  1AOC A;  1VPP V;  1WQ8 A;  2QCW A;  1QFW B;  2GNN A;  1PDG C;  1REW B;  1VPF C;  3MJG B;  1PDG B;  1FL7 B;  3HH2 B;  2QJA A;  1VPF B;  2PJY A;  1QFW A;  2QR0 C;  1REU A;  1WAQ A;  1FLT V;  2FJH V;  1REW A;  1S4Y D;  2R53 B;  2QR0 I;  2QJA B;  1PDG A;  1FL7 A;  2XV7 A;  3HH2 A;  3MJG A;  1VPF A;  2QJ9 A;  1RV6 V;  2GYR D;  1TGJ A;  2VPF D;  1NYU B;  2VPF H;  2FJG V;  3KFD C;  1QTY R;  2ARV B;  2GYR B;  1CZ8 W;  1SGF B;  2R53 A;  2V5E B;  2VPF B;  3EO1 C;  1KTZ A;  1DZ7 A;  1AGQ C;  2QJB B;  2X1X E;  3EVS B;  2BHK A;  2FJG W;  2ARV A;  1TZH V;  3EO1 I;  2VPF A;  1HRP B;  2QJB A;  3KFD A;  1AOC B;  2GYR F;  2VPF F;  2ARP A;  2GNN D;  2QR0 U;  1WQ9 A;  2VWE B;  1BND B;  1ZKZ A;  1B98 A;  2VWE A;  2R52 B;  1ES7 C;  1BND A;  1FL7 D;  2B0U B;  1VPF D;  2GYR E;  3QTK C;  2VPF E;  2QJ9 B;  1FZV A;  2R52 A;  2B0U A;  3EO1 L;  1CZ8 V;  2C7W A;  1NYU D;  2QR0 O;  3QTK A;  1BTG B;  3BDY V;  3KFD D;  1NT3 A;  3BMP A;  3KFD B;  1AGQ D;  2X1W C;  1AGQ B;  2QR0 V;  1BMP A;  1AGQ A;  1XWD B;  2GOO A;  1NYS B;  1XWD A;  1FZV B;  1M4U L;  3QTK D;  1SGF Y;  2C7W B;  3BK3 B;  2QR0 D;  2QCQ B;  3QTK B;  2GYZ A;  1B8M A;  1ES7 A;  2XAC B;  3BK3 A;  1QTY S;  1LXI A;  1TFG A;  1HCN B;  1XWD E;  3QTK F;  2XAC A;  2ASK B;  1QTY W;  2GOO D;  2GNN C;  2GH0 C;  1TGK A;  2X1W B;  1HCN A;  2ASK A;  1XWD D;  1MJV B;  2X1W A;  3FUB D;  2H62 A;  1BJ1 W;  3QTK E;  1E9J A;  1VPP W;  1FL7 C;  3FUB B;  1MJV A;  3B4V B;  2P6A B;  3B4V A;  1KLA B;  1WQ9 B;  1S4Y B;  2TGI A;  3B4V F;  1KLC B;  1FLT W;  2FJH W;  2GYR C;  2P6A A;  2VPF C;  1TZI V;  2H64 A;  1KLA A;  1KAT V;  1RV6 W; 
#chains in the KnotProt database with same CATH homology
 1KLC A;  1LX5 A;  1QTY V;  2GYR A;  1KAT W;  2QCQ A;  2X1W D;  2GH0 D;  3B4V E;  2QCW B;  1TZH W;  2VPF G;  1HD4 A;  2GNN B;  2H62 B;  1BJ1 V;  1HRP A;  2QR0 J;  2QR0 P;  1AOC A;  1VPP V;  1WQ8 A;  2QCW A;  1QFW B;  2GNN A;  1PDG C;  1REW B;  1VPF C;  3MJG B;  1PDG B;  1FL7 B;  3HH2 B;  2QJA A;  1VPF B;  2PJY A;  1QFW A;  2QR0 C;  1REU A;  1WAQ A;  1FLT V;  2FJH V;  1REW A;  1S4Y D;  2R53 B;  2QR0 I;  2QJA B;  1PDG A;  1FL7 A;  2XV7 A;  3HH2 A;  3MJG A;  1VPF A;  2QJ9 A;  1RV6 V;  2GYR D;  1TGJ A;  2VPF D;  1NYU B;  2VPF H;  2FJG V;  3KFD C;  1QTY R;  2ARV B;  2GYR B;  1CZ8 W;  1SGF B;  2R53 A;  2V5E B;  2VPF B;  3EO1 C;  1KTZ A;  1DZ7 A;  1AGQ C;  2QJB B;  2X1X E;  3EVS B;  2BHK A;  2FJG W;  2ARV A;  1TZH V;  3EO1 I;  2VPF A;  1HRP B;  2QJB A;  3KFD A;  1AOC B;  2GYR F;  2VPF F;  2ARP A;  2GNN D;  2QR0 U;  1WQ9 A;  2VWE B;  1BND B;  1ZKZ A;  1B98 A;  2VWE A;  2R52 B;  1ES7 C;  1BND A;  1FL7 D;  2B0U B;  1VPF D;  2GYR E;  3QTK C;  2VPF E;  2QJ9 B;  1FZV A;  2R52 A;  2B0U A;  3EO1 L;  1CZ8 V;  2C7W A;  1NYU D;  2QR0 O;  3QTK A;  1BTG B;  3BDY V;  3KFD D;  1NT3 A;  3BMP A;  3KFD B;  1AGQ D;  2X1W C;  1AGQ B;  2QR0 V;  1BMP A;  1AGQ A;  1XWD B;  2GOO A;  1NYS B;  1XWD A;  1FZV B;  1M4U L;  3QTK D;  1SGF Y;  2C7W B;  3BK3 B;  2QR0 D;  2QCQ B;  3QTK B;  2GYZ A;  1B8M A;  1ES7 A;  2XAC B;  3BK3 A;  1QTY S;  1LXI A;  1TFG A;  1HCN B;  1XWD E;  3QTK F;  2XAC A;  2ASK B;  1QTY W;  2GOO D;  2GNN C;  2GH0 C;  1TGK A;  2X1W B;  1HCN A;  2ASK A;  1XWD D;  1MJV B;  2X1W A;  3FUB D;  2H62 A;  1BJ1 W;  3QTK E;  1E9J A;  1VPP W;  1FL7 C;  3FUB B;  1MJV A;  3B4V B;  2P6A B;  3B4V A;  1KLA B;  1WQ9 B;  1S4Y B;  2TGI A;  3B4V F;  1KLC B;  1FLT W;  2FJH W;  2GYR C;  2P6A A;  2VPF C;  1TZI V;  2H64 A;  1KLA A;  1KAT V;  1RV6 W;

1KTZA 2TGIA 4KXZA 6I9JA 6XM2I
similar chains in the KnotProt database (40% sequence similarity)

7RCOA 8DC0B 8FXSA 8FXVA
similar chains in the pdb database (40% sequence similarity)

#similar chains in the KnotProt database (40% sequence similarity)
1KTZ A; 2TGI A; 4KXZ A; 6I9J A; 6XM2 I; 
#similar chains, but unknotted

#similar chains in the pdb database (40% sequence similarity)
7RCO A; 8DC0 B; 8FXS A; 8FXV A;