1TWHB

Rna polymerase ii complexed with 2'datp
Cysteine knot
Loop Piercing
view details
1166-c-1182-b-1185-c-1185 1163-b-1185
Chain Sequence
FEDESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEDSTLIE------------------ISFGKIYVTKPMVNESDGVTHALYPQEARLRNLTYSSGLFVDVKKRTYEKVFIGRLPIMLRSKNCYLS-------------------------EATESDLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSALEKGSRFISTLQVKLYGREGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEKRIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVELAINAKTITSGLKYALATGNWGAGVSQVLNRYTYSSTLSHLRRT--------NTPIAKPRQLHNTHWGLVCPAETPEGQACG---------LVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDY------VPHQSPDATRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESLGHKELKVRKGHIAKLMATEYQDEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPDVDPAKRIRVSHHATTFTHCEIHPSMILGVAA---------SIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILY---------YPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDDGLIAPGVRVSGEDVIIGKTTSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAI----------------PSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPGLRFGEMERDCMIAHGAASFLKERLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRLYTDRSRDF
sequence length 1207
structure length 1091
publication title Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.
pubmed doi rcsb
molecule tags Transcription
molecule keywords DNA-directed RNA polymerase II largest subunit
missing residues 54-71, 122-146, 421-428, 451-459, 486-491, 652-660, 696-704, 900-915, 1094-1109
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2004-06-30
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.50.150 Mainly Beta Beta Barrel OB fold (Dihydrolipoamide Acetyltransferase, E2P) OB fold (Dihydrolipoamide Acetyltransferase, E2P) 1twhB07
3.90.1110.10 Alpha Beta Alpha-Beta Complex Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3 Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3 1twhB04
1TWHB 1TWGB
chains in the KnotProt database with same CATH superfamily
1TWHB 1K3RA 1TWGB
chains in the KnotProt database with same CATH topology
1TWHB 1TWGB
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1TWH B;  1TWG B; 
#chains in the KnotProt database with same CATH topology
 1TWH B;  1K3R A;  1TWG B; 
#chains in the KnotProt database with same CATH homology
 1TWH B;  1TWG B; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling