1BY7A

Human plasminogen activator inhibitor-2. loop (66-98) deletion mutant
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 177-350 174 1-176, 351-381 176 31 knot
Chain Sequence
EDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVG-AADKIHSSFRSLSSAINL------LESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLYPFRVN---SAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTGPQFVADHPF-----------------LFLIMHKITNCILFFGRFSSP
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 169-323 155 1-168, 324-354 168 31 knot
view details
2.1 171-328 158 1-168, 336-354 169-170, 329-335 168 19 slipknot
view details
3.1 170-336 167 337-354 1-168 169-169 168 17 slipknot
view details
3.1 172-336 165 337-354 1-169 170-171 169 17 slipknot
missing residues 64, 82-87, 182-184, 334-350
publication title The crystal structure of plasminogen activator inhibitor 2 at 2.0 A resolution: implications for serpin function.
pubmed doi rcsb
structure length 354
molecule tags Protein binding
source organism Homo sapiens
sequence length 381
total genus Genus: 114
molecule keywords PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-2)
ec nomenclature
pdb deposition date 1998-10-27
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 1by7A01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 1by7A02
2WXZC 1BY7A 3NDAA
chains in the KnotProt database with same CATH superfamily
2WXZC 1BY7A 3NDAA
chains in the KnotProt database with same CATH topology
2WXZC 1BY7A 3NDAA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 2WXZ C;  1BY7 A;  3NDA A; 
#chains in the KnotProt database with same CATH topology
 2WXZ C;  1BY7 A;  3NDA A; 
#chains in the KnotProt database with same CATH homology
 2WXZ C;  1BY7 A;  3NDA A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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