1KTZA

Crystal structure of the human tgf-beta type ii receptor extracellular domain in complex with tgf-beta3
Cysteine knot
Loop Piercing
view details
44-c-48-b-111-c-109 15-b-78
Chain Sequence
ENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSAS------------------ASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS
sequence length 100
structure length 82
publication title Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex.
pubmed rcsb
molecule tags Cytokine/cytokine receptor
molecule keywords TRANSFORMING GROWTH FACTOR BETA 3
source organism Homo sapiens
missing residues 43-60
ec nomenclature
pdb deposition date 2002-01-18
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 1ktzA00
1WQ9A 2GH0D 2QR0J 1MJVB 2VPFG 2QJ9B 3QTKF 1XWDE 1AGQB 1FZVB 2VPFF 2ARVA 2GNNB 2QJBB 1WAQA 1REWB 1HCNB 2FJHW 2X1XE 2FJHV 1TZIV 2XACB 1AGQC 1ES7A 3EO1C 1BNDA 1QFWB 2GNNC 1TZHV 2VWEA 2QJAA 3B4VF 2QCWA 2QR0C 1PDGB 1RV6W 3MJGB 1RV6V 1TFGA 1HRPB 3HH2B 2QR0O 1AGQD 3B4VA 1XWDB 1PDGC 2GNND 2B0UA 3QTKE 2ASKB 1BJ1W 1NYUB 1QTYR 1BMPA 1ZKZA 2QR0D 1BJ1V 1FL7B 2R52B 2VPFE 3KFDB 1LX5A 2GYRF 1KLCA 2X1WB 2H64A 2PJYA 2VPFC 1AOCA 2GOOA 1DZ7A 1KATW 2R53B 1VPFB 1WQ9B 1FL7C 1KATV 2QR0U 2QCQB 1E9JA 2QJ9A 3KFDC 2X1WC 1AGQA 2GYRA 2P6AA 2ARVB 2ARPA 3EO1L 1VPFC 1XWDD 1KLAA 2QR0I 1SGFY 2C7WA 1NYUD 3BK3A 3QTKB 1FL7D 2H62A 3KFDD 1BNDB 2VPFB 2X1WD 2VWEB 3FUBB 2QJAB 2QCWB 1B98A 2QR0V 2V5EB 1HRPA 1REUA 1VPFD 3QTKC 1ES7C 2XV7A 1FLTW 1TGJA 3B4VB 1QTYS 2B0UB 1MJVA 2GYZA 3B4VE 1FZVA 3BMPA 2GNNA 3EO1I 1NYSB 1NT3A 3QTKD 2QJBA 2BHKA 1REWA 2VPFD 1AOCB 3FUBD 1HCNA 2QCQA 1HD4A 2XACA 2QR0P 1QFWA 1S4YB 2GYRB 2TGIA 1VPPW 2P6AB 1VPPV 1PDGA 3MJGA 2GYRE 1KLAB 3HH2A 1M4UL 2C7WB 1B8MA 1QTYW 3QTKA 1KTZA 3BK3B 2GYRC 1CZ8W 1QTYV 1TZHW 3EVSB 1CZ8V 1XWDA 2H62B 1FLTV 2VPFA 2GH0C 3BDYV 1WQ8A 2ASKA 2R52A 1LXIA 2FJGW 1FL7A 2FJGV 3KFDA 2GOOD 2VPFH 2X1WA 1TGKA 1KLCB 1S4YD 1SGFB 2GYRD 2R53A 1VPFA 1BTGB
chains in the KnotProt database with same CATH superfamily
1WQ9A 2GH0D 2QR0J 1MJVB 2VPFG 2QJ9B 3QTKF 1XWDE 1AGQB 1FZVB 2VPFF 2ARVA 2GNNB 2QJBB 1WAQA 1REWB 1HCNB 2FJHW 2X1XE 2FJHV 1TZIV 2XACB 1AGQC 1ES7A 3EO1C 1BNDA 1QFWB 2GNNC 1TZHV 2VWEA 2QJAA 3B4VF 2QCWA 2QR0C 1PDGB 1RV6W 3MJGB 1RV6V 1TFGA 1HRPB 3HH2B 2QR0O 1AGQD 3B4VA 1XWDB 1PDGC 2GNND 2B0UA 3QTKE 2ASKB 1BJ1W 1NYUB 1QTYR 1BMPA 1ZKZA 2QR0D 1BJ1V 1FL7B 2R52B 2VPFE 3KFDB 1LX5A 2GYRF 1KLCA 2X1WB 2H64A 2PJYA 2VPFC 1AOCA 2GOOA 1DZ7A 1KATW 2R53B 1VPFB 1WQ9B 1FL7C 1KATV 2QR0U 2QCQB 1E9JA 2QJ9A 3KFDC 2X1WC 1AGQA 2GYRA 2P6AA 2ARVB 2ARPA 3EO1L 1VPFC 1XWDD 1KLAA 2QR0I 1SGFY 2C7WA 1NYUD 3BK3A 3QTKB 1FL7D 2H62A 3KFDD 1BNDB 2VPFB 2X1WD 2VWEB 3FUBB 2QJAB 2QCWB 1B98A 2QR0V 2V5EB 1HRPA 1REUA 1VPFD 3QTKC 1ES7C 2XV7A 1FLTW 1TGJA 3B4VB 1QTYS 2B0UB 1MJVA 2GYZA 3B4VE 1FZVA 3BMPA 2GNNA 3EO1I 1NYSB 1NT3A 3QTKD 2QJBA 2BHKA 1REWA 2VPFD 1AOCB 3FUBD 1HCNA 2QCQA 1HD4A 2XACA 2QR0P 1QFWA 1S4YB 2GYRB 2TGIA 1VPPW 2P6AB 1VPPV 1PDGA 3MJGA 2GYRE 1KLAB 3HH2A 1M4UL 2C7WB 1B8MA 1QTYW 3QTKA 1KTZA 3BK3B 2GYRC 1CZ8W 1QTYV 1TZHW 3EVSB 1CZ8V 1XWDA 2H62B 1FLTV 2VPFA 2GH0C 3BDYV 1WQ8A 2ASKA 2R52A 1LXIA 2FJGW 1FL7A 2FJGV 3KFDA 2GOOD 2VPFH 2X1WA 1TGKA 1KLCB 1S4YD 1SGFB 2GYRD 2R53A 1VPFA 1BTGB
chains in the KnotProt database with same CATH topology
1WQ9A 2GH0D 2QR0J 1MJVB 2VPFG 2QJ9B 3QTKF 1XWDE 1AGQB 1FZVB 2VPFF 2ARVA 2GNNB 2QJBB 1WAQA 1REWB 1HCNB 2FJHW 2X1XE 2FJHV 1TZIV 2XACB 1AGQC 1ES7A 3EO1C 1BNDA 1QFWB 2GNNC 1TZHV 2VWEA 2QJAA 3B4VF 2QCWA 2QR0C 1PDGB 1RV6W 3MJGB 1RV6V 1TFGA 1HRPB 3HH2B 2QR0O 1AGQD 3B4VA 1XWDB 1PDGC 2GNND 2B0UA 3QTKE 2ASKB 1BJ1W 1NYUB 1QTYR 1BMPA 1ZKZA 2QR0D 1BJ1V 1FL7B 2R52B 2VPFE 3KFDB 1LX5A 2GYRF 1KLCA 2X1WB 2H64A 2PJYA 2VPFC 1AOCA 2GOOA 1DZ7A 1KATW 2R53B 1VPFB 1WQ9B 1FL7C 1KATV 2QR0U 2QCQB 1E9JA 2QJ9A 3KFDC 2X1WC 1AGQA 2GYRA 2P6AA 2ARVB 2ARPA 3EO1L 1VPFC 1XWDD 1KLAA 2QR0I 1SGFY 2C7WA 1NYUD 3BK3A 3QTKB 1FL7D 2H62A 3KFDD 1BNDB 2VPFB 2X1WD 2VWEB 3FUBB 2QJAB 2QCWB 1B98A 2QR0V 2V5EB 1HRPA 1REUA 1VPFD 3QTKC 1ES7C 2XV7A 1FLTW 1TGJA 3B4VB 1QTYS 2B0UB 1MJVA 2GYZA 3B4VE 1FZVA 3BMPA 2GNNA 3EO1I 1NYSB 1NT3A 3QTKD 2QJBA 2BHKA 1REWA 2VPFD 1AOCB 3FUBD 1HCNA 2QCQA 1HD4A 2XACA 2QR0P 1QFWA 1S4YB 2GYRB 2TGIA 1VPPW 2P6AB 1VPPV 1PDGA 3MJGA 2GYRE 1KLAB 3HH2A 1M4UL 2C7WB 1B8MA 1QTYW 3QTKA 1KTZA 3BK3B 2GYRC 1CZ8W 1QTYV 1TZHW 3EVSB 1CZ8V 1XWDA 2H62B 1FLTV 2VPFA 2GH0C 3BDYV 1WQ8A 2ASKA 2R52A 1LXIA 2FJGW 1FL7A 2FJGV 3KFDA 2GOOD 2VPFH 2X1WA 1TGKA 1KLCB 1S4YD 1SGFB 2GYRD 2R53A 1VPFA 1BTGB
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1WQ9 A;  2GH0 D;  2QR0 J;  1MJV B;  2VPF G;  2QJ9 B;  3QTK F;  1XWD E;  1AGQ B;  1FZV B;  2VPF F;  2ARV A;  2GNN B;  2QJB B;  1WAQ A;  1REW B;  1HCN B;  2FJH W;  2X1X E;  2FJH V;  1TZI V;  2XAC B;  1AGQ C;  1ES7 A;  3EO1 C;  1BND A;  1QFW B;  2GNN C;  1TZH V;  2VWE A;  2QJA A;  3B4V F;  2QCW A;  2QR0 C;  1PDG B;  1RV6 W;  3MJG B;  1RV6 V;  1TFG A;  1HRP B;  3HH2 B;  2QR0 O;  1AGQ D;  3B4V A;  1XWD B;  1PDG C;  2GNN D;  2B0U A;  3QTK E;  2ASK B;  1BJ1 W;  1NYU B;  1QTY R;  1BMP A;  1ZKZ A;  2QR0 D;  1BJ1 V;  1FL7 B;  2R52 B;  2VPF E;  3KFD B;  1LX5 A;  2GYR F;  1KLC A;  2X1W B;  2H64 A;  2PJY A;  2VPF C;  1AOC A;  2GOO A;  1DZ7 A;  1KAT W;  2R53 B;  1VPF B;  1WQ9 B;  1FL7 C;  1KAT V;  2QR0 U;  2QCQ B;  1E9J A;  2QJ9 A;  3KFD C;  2X1W C;  1AGQ A;  2GYR A;  2P6A A;  2ARV B;  2ARP A;  3EO1 L;  1VPF C;  1XWD D;  1KLA A;  2QR0 I;  1SGF Y;  2C7W A;  1NYU D;  3BK3 A;  3QTK B;  1FL7 D;  2H62 A;  3KFD D;  1BND B;  2VPF B;  2X1W D;  2VWE B;  3FUB B;  2QJA B;  2QCW B;  1B98 A;  2QR0 V;  2V5E B;  1HRP A;  1REU A;  1VPF D;  3QTK C;  1ES7 C;  2XV7 A;  1FLT W;  1TGJ A;  3B4V B;  1QTY S;  2B0U B;  1MJV A;  2GYZ A;  3B4V E;  1FZV A;  3BMP A;  2GNN A;  3EO1 I;  1NYS B;  1NT3 A;  3QTK D;  2QJB A;  2BHK A;  1REW A;  2VPF D;  1AOC B;  3FUB D;  1HCN A;  2QCQ A;  1HD4 A;  2XAC A;  2QR0 P;  1QFW A;  1S4Y B;  2GYR B;  2TGI A;  1VPP W;  2P6A B;  1VPP V;  1PDG A;  3MJG A;  2GYR E;  1KLA B;  3HH2 A;  1M4U L;  2C7W B;  1B8M A;  1QTY W;  3QTK A;  1KTZ A;  3BK3 B;  2GYR C;  1CZ8 W;  1QTY V;  1TZH W;  3EVS B;  1CZ8 V;  1XWD A;  2H62 B;  1FLT V;  2VPF A;  2GH0 C;  3BDY V;  1WQ8 A;  2ASK A;  2R52 A;  1LXI A;  2FJG W;  1FL7 A;  2FJG V;  3KFD A;  2GOO D;  2VPF H;  2X1W A;  1TGK A;  1KLC B;  1S4Y D;  1SGF B;  2GYR D;  2R53 A;  1VPF A;  1BTG B; 
#chains in the KnotProt database with same CATH topology
 1WQ9 A;  2GH0 D;  2QR0 J;  1MJV B;  2VPF G;  2QJ9 B;  3QTK F;  1XWD E;  1AGQ B;  1FZV B;  2VPF F;  2ARV A;  2GNN B;  2QJB B;  1WAQ A;  1REW B;  1HCN B;  2FJH W;  2X1X E;  2FJH V;  1TZI V;  2XAC B;  1AGQ C;  1ES7 A;  3EO1 C;  1BND A;  1QFW B;  2GNN C;  1TZH V;  2VWE A;  2QJA A;  3B4V F;  2QCW A;  2QR0 C;  1PDG B;  1RV6 W;  3MJG B;  1RV6 V;  1TFG A;  1HRP B;  3HH2 B;  2QR0 O;  1AGQ D;  3B4V A;  1XWD B;  1PDG C;  2GNN D;  2B0U A;  3QTK E;  2ASK B;  1BJ1 W;  1NYU B;  1QTY R;  1BMP A;  1ZKZ A;  2QR0 D;  1BJ1 V;  1FL7 B;  2R52 B;  2VPF E;  3KFD B;  1LX5 A;  2GYR F;  1KLC A;  2X1W B;  2H64 A;  2PJY A;  2VPF C;  1AOC A;  2GOO A;  1DZ7 A;  1KAT W;  2R53 B;  1VPF B;  1WQ9 B;  1FL7 C;  1KAT V;  2QR0 U;  2QCQ B;  1E9J A;  2QJ9 A;  3KFD C;  2X1W C;  1AGQ A;  2GYR A;  2P6A A;  2ARV B;  2ARP A;  3EO1 L;  1VPF C;  1XWD D;  1KLA A;  2QR0 I;  1SGF Y;  2C7W A;  1NYU D;  3BK3 A;  3QTK B;  1FL7 D;  2H62 A;  3KFD D;  1BND B;  2VPF B;  2X1W D;  2VWE B;  3FUB B;  2QJA B;  2QCW B;  1B98 A;  2QR0 V;  2V5E B;  1HRP A;  1REU A;  1VPF D;  3QTK C;  1ES7 C;  2XV7 A;  1FLT W;  1TGJ A;  3B4V B;  1QTY S;  2B0U B;  1MJV A;  2GYZ A;  3B4V E;  1FZV A;  3BMP A;  2GNN A;  3EO1 I;  1NYS B;  1NT3 A;  3QTK D;  2QJB A;  2BHK A;  1REW A;  2VPF D;  1AOC B;  3FUB D;  1HCN A;  2QCQ A;  1HD4 A;  2XAC A;  2QR0 P;  1QFW A;  1S4Y B;  2GYR B;  2TGI A;  1VPP W;  2P6A B;  1VPP V;  1PDG A;  3MJG A;  2GYR E;  1KLA B;  3HH2 A;  1M4U L;  2C7W B;  1B8M A;  1QTY W;  3QTK A;  1KTZ A;  3BK3 B;  2GYR C;  1CZ8 W;  1QTY V;  1TZH W;  3EVS B;  1CZ8 V;  1XWD A;  2H62 B;  1FLT V;  2VPF A;  2GH0 C;  3BDY V;  1WQ8 A;  2ASK A;  2R52 A;  1LXI A;  2FJG W;  1FL7 A;  2FJG V;  3KFD A;  2GOO D;  2VPF H;  2X1W A;  1TGK A;  1KLC B;  1S4Y D;  1SGF B;  2GYR D;  2R53 A;  1VPF A;  1BTG B; 
#chains in the KnotProt database with same CATH homology
 1WQ9 A;  2GH0 D;  2QR0 J;  1MJV B;  2VPF G;  2QJ9 B;  3QTK F;  1XWD E;  1AGQ B;  1FZV B;  2VPF F;  2ARV A;  2GNN B;  2QJB B;  1WAQ A;  1REW B;  1HCN B;  2FJH W;  2X1X E;  2FJH V;  1TZI V;  2XAC B;  1AGQ C;  1ES7 A;  3EO1 C;  1BND A;  1QFW B;  2GNN C;  1TZH V;  2VWE A;  2QJA A;  3B4V F;  2QCW A;  2QR0 C;  1PDG B;  1RV6 W;  3MJG B;  1RV6 V;  1TFG A;  1HRP B;  3HH2 B;  2QR0 O;  1AGQ D;  3B4V A;  1XWD B;  1PDG C;  2GNN D;  2B0U A;  3QTK E;  2ASK B;  1BJ1 W;  1NYU B;  1QTY R;  1BMP A;  1ZKZ A;  2QR0 D;  1BJ1 V;  1FL7 B;  2R52 B;  2VPF E;  3KFD B;  1LX5 A;  2GYR F;  1KLC A;  2X1W B;  2H64 A;  2PJY A;  2VPF C;  1AOC A;  2GOO A;  1DZ7 A;  1KAT W;  2R53 B;  1VPF B;  1WQ9 B;  1FL7 C;  1KAT V;  2QR0 U;  2QCQ B;  1E9J A;  2QJ9 A;  3KFD C;  2X1W C;  1AGQ A;  2GYR A;  2P6A A;  2ARV B;  2ARP A;  3EO1 L;  1VPF C;  1XWD D;  1KLA A;  2QR0 I;  1SGF Y;  2C7W A;  1NYU D;  3BK3 A;  3QTK B;  1FL7 D;  2H62 A;  3KFD D;  1BND B;  2VPF B;  2X1W D;  2VWE B;  3FUB B;  2QJA B;  2QCW B;  1B98 A;  2QR0 V;  2V5E B;  1HRP A;  1REU A;  1VPF D;  3QTK C;  1ES7 C;  2XV7 A;  1FLT W;  1TGJ A;  3B4V B;  1QTY S;  2B0U B;  1MJV A;  2GYZ A;  3B4V E;  1FZV A;  3BMP A;  2GNN A;  3EO1 I;  1NYS B;  1NT3 A;  3QTK D;  2QJB A;  2BHK A;  1REW A;  2VPF D;  1AOC B;  3FUB D;  1HCN A;  2QCQ A;  1HD4 A;  2XAC A;  2QR0 P;  1QFW A;  1S4Y B;  2GYR B;  2TGI A;  1VPP W;  2P6A B;  1VPP V;  1PDG A;  3MJG A;  2GYR E;  1KLA B;  3HH2 A;  1M4U L;  2C7W B;  1B8M A;  1QTY W;  3QTK A;  1KTZ A;  3BK3 B;  2GYR C;  1CZ8 W;  1QTY V;  1TZH W;  3EVS B;  1CZ8 V;  1XWD A;  2H62 B;  1FLT V;  2VPF A;  2GH0 C;  3BDY V;  1WQ8 A;  2ASK A;  2R52 A;  1LXI A;  2FJG W;  1FL7 A;  2FJG V;  3KFD A;  2GOO D;  2VPF H;  2X1W A;  1TGK A;  1KLC B;  1S4Y D;  1SGF B;  2GYR D;  2R53 A;  1VPF A;  1BTG B; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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