2X1WB

Crystal structure of vegf-c in complex with domains 2 and 3 of vegfr2
Cysteine knot
Loop Piercing
view details
162-c-166-b-211-c-209 131-b-173
Chain Sequence
EILKSIDNEWRKTQCMPREVAIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSK
sequence length 98
structure length 98
publication title Structural Determinants of Growth Factor Binding and Specificity by Vegf Receptor 2.
pubmed doi rcsb
molecule tags Hormone/signaling protein
molecule keywords VASCULAR ENDOTHELIAL GROWTH FACTOR C
source organism Homo sapiens
ec nomenclature
pdb deposition date 2010-01-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.90.10 Mainly Beta Ribbon Cystine Knot Cytokines, subunit B Cystine-knot cytokines 2x1wB00
2GYRB 1HCNA 2QCWA 2GYRF 3KFDD 3FUBD 2QCWB 2X1WD 1FL7C 1XWDE 2PJYA 2QJBB 1FZVA 1BJ1W 1PDGC 1KATV 1SGFB 1LXIA 2QCQA 2ARVB 3B4VE 2ASKA 2QCQB 1AGQA 2H62A 2XV7A 2ASKB 2QR0O 1KLCA 1AGQB 2FJGV 1KLCB 1AGQD 2VPFA 2VWEA 3EVSB 2B0UB 1QFWB 2VPFB 2VWEB 1AOCA 3EO1L 2VPFF 2FJHV 3HH2A 3BDYV 1HD4A 1E9JA 2V5EB 2VPFD 3QTKA 1VPPW 2QR0C 1VPFB 2GYRA 3QTKB 2QR0I 2GNNC 1RV6W 1TZHW 3QTKF 1CZ8V 1TZIV 3QTKD 1NYUB 2QJBA 2GYRD 1TFGA 1FL7B 1KATW 2ARVA 1PDGB 2GH0D 1BMPA 1REWA 1WQ9B 1REWB 2QR0J 1BTGB 3BK3B 2B0UA 1QFWA 2P6AB 1B98A 3KFDC 2BHKA 1ES7A 2X1WC 2VPFH 2FJHW 2GOOA 2QR0P 1VPFA 1FLTW 3EO1C 1XWDA 3EO1I 2GYRE 1CZ8W 1XWDB 2ARPA 2X1XE 2GOOD 1BJ1V 1VPFD 2GNNB 2XACB 1LX5A 1XWDD 3B4VA 2R52B 1FL7A 1QTYV 1NYUD 1AGQC 1HRPA 3B4VB 3BMPA 1PDGA 3B4VF 2C7WB 1HRPB 1KLAB 1WQ9A 1TGJA 2TGIA 1FL7D 2R53B 2VPFC 3BK3A 2P6AA 1REUA 2FJGW 3MJGB 2QJAA 1NT3A 2H64A 1VPFC 3QTKC 1VPPV 2QJAB 2VPFE 1MJVB 2GYRC 1S4YB 3KFDB 3FUBB 1RV6V 2QR0U 2QR0V 2X1WB 2QJ9B 1S4YD 3QTKE 1TGKA 1HCNB 2GH0C 1SGFY 2GNNA 2VPFG 2XACA 1QTYR 2R52A 1DZ7A 1FZVB 2QR0D 2GYZA 1QTYW 1M4UL 2GNND 1WQ8A 1BNDA 2C7WA 1KLAA 1WAQA 1ZKZA 1BNDB 2R53A 2H62B 1KTZA 3MJGA 1ES7C 1B8MA 1NYSB 1QTYS 1MJVA 1AOCB 1FLTV 3KFDA 3HH2B 2X1WA 2QJ9A 1TZHV
chains in the KnotProt database with same CATH superfamily
2GYRB 1HCNA 2QCWA 2GYRF 3KFDD 3FUBD 2QCWB 2X1WD 1FL7C 1XWDE 2PJYA 2QJBB 1FZVA 1BJ1W 1PDGC 1KATV 1SGFB 1LXIA 2QCQA 2ARVB 3B4VE 2ASKA 2QCQB 1AGQA 2H62A 2XV7A 2ASKB 2QR0O 1KLCA 1AGQB 2FJGV 1KLCB 1AGQD 2VPFA 2VWEA 3EVSB 2B0UB 1QFWB 2VPFB 2VWEB 1AOCA 3EO1L 2VPFF 2FJHV 3HH2A 3BDYV 1HD4A 1E9JA 2V5EB 2VPFD 3QTKA 1VPPW 2QR0C 1VPFB 2GYRA 3QTKB 2QR0I 2GNNC 1RV6W 1TZHW 3QTKF 1CZ8V 1TZIV 3QTKD 1NYUB 2QJBA 2GYRD 1TFGA 1FL7B 1KATW 2ARVA 1PDGB 2GH0D 1BMPA 1REWA 1WQ9B 1REWB 2QR0J 1BTGB 3BK3B 2B0UA 1QFWA 2P6AB 1B98A 3KFDC 2BHKA 1ES7A 2X1WC 2VPFH 2FJHW 2GOOA 2QR0P 1VPFA 1FLTW 3EO1C 1XWDA 3EO1I 2GYRE 1CZ8W 1XWDB 2ARPA 2X1XE 2GOOD 1BJ1V 1VPFD 2GNNB 2XACB 1LX5A 1XWDD 3B4VA 2R52B 1FL7A 1QTYV 1NYUD 1AGQC 1HRPA 3B4VB 3BMPA 1PDGA 3B4VF 2C7WB 1HRPB 1KLAB 1WQ9A 1TGJA 2TGIA 1FL7D 2R53B 2VPFC 3BK3A 2P6AA 1REUA 2FJGW 3MJGB 2QJAA 1NT3A 2H64A 1VPFC 3QTKC 1VPPV 2QJAB 2VPFE 1MJVB 2GYRC 1S4YB 3KFDB 3FUBB 1RV6V 2QR0U 2QR0V 2X1WB 2QJ9B 1S4YD 3QTKE 1TGKA 1HCNB 2GH0C 1SGFY 2GNNA 2VPFG 2XACA 1QTYR 2R52A 1DZ7A 1FZVB 2QR0D 2GYZA 1QTYW 1M4UL 2GNND 1WQ8A 1BNDA 2C7WA 1KLAA 1WAQA 1ZKZA 1BNDB 2R53A 2H62B 1KTZA 3MJGA 1ES7C 1B8MA 1NYSB 1QTYS 1MJVA 1AOCB 1FLTV 3KFDA 3HH2B 2X1WA 2QJ9A 1TZHV
chains in the KnotProt database with same CATH topology
2GYRB 1HCNA 2QCWA 2GYRF 3KFDD 3FUBD 2QCWB 2X1WD 1FL7C 1XWDE 2PJYA 2QJBB 1FZVA 1BJ1W 1PDGC 1KATV 1SGFB 1LXIA 2QCQA 2ARVB 3B4VE 2ASKA 2QCQB 1AGQA 2H62A 2XV7A 2ASKB 2QR0O 1KLCA 1AGQB 2FJGV 1KLCB 1AGQD 2VPFA 2VWEA 3EVSB 2B0UB 1QFWB 2VPFB 2VWEB 1AOCA 3EO1L 2VPFF 2FJHV 3HH2A 3BDYV 1HD4A 1E9JA 2V5EB 2VPFD 3QTKA 1VPPW 2QR0C 1VPFB 2GYRA 3QTKB 2QR0I 2GNNC 1RV6W 1TZHW 3QTKF 1CZ8V 1TZIV 3QTKD 1NYUB 2QJBA 2GYRD 1TFGA 1FL7B 1KATW 2ARVA 1PDGB 2GH0D 1BMPA 1REWA 1WQ9B 1REWB 2QR0J 1BTGB 3BK3B 2B0UA 1QFWA 2P6AB 1B98A 3KFDC 2BHKA 1ES7A 2X1WC 2VPFH 2FJHW 2GOOA 2QR0P 1VPFA 1FLTW 3EO1C 1XWDA 3EO1I 2GYRE 1CZ8W 1XWDB 2ARPA 2X1XE 2GOOD 1BJ1V 1VPFD 2GNNB 2XACB 1LX5A 1XWDD 3B4VA 2R52B 1FL7A 1QTYV 1NYUD 1AGQC 1HRPA 3B4VB 3BMPA 1PDGA 3B4VF 2C7WB 1HRPB 1KLAB 1WQ9A 1TGJA 2TGIA 1FL7D 2R53B 2VPFC 3BK3A 2P6AA 1REUA 2FJGW 3MJGB 2QJAA 1NT3A 2H64A 1VPFC 3QTKC 1VPPV 2QJAB 2VPFE 1MJVB 2GYRC 1S4YB 3KFDB 3FUBB 1RV6V 2QR0U 2QR0V 2X1WB 2QJ9B 1S4YD 3QTKE 1TGKA 1HCNB 2GH0C 1SGFY 2GNNA 2VPFG 2XACA 1QTYR 2R52A 1DZ7A 1FZVB 2QR0D 2GYZA 1QTYW 1M4UL 2GNND 1WQ8A 1BNDA 2C7WA 1KLAA 1WAQA 1ZKZA 1BNDB 2R53A 2H62B 1KTZA 3MJGA 1ES7C 1B8MA 1NYSB 1QTYS 1MJVA 1AOCB 1FLTV 3KFDA 3HH2B 2X1WA 2QJ9A 1TZHV
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 2GYR B;  1HCN A;  2QCW A;  2GYR F;  3KFD D;  3FUB D;  2QCW B;  2X1W D;  1FL7 C;  1XWD E;  2PJY A;  2QJB B;  1FZV A;  1BJ1 W;  1PDG C;  1KAT V;  1SGF B;  1LXI A;  2QCQ A;  2ARV B;  3B4V E;  2ASK A;  2QCQ B;  1AGQ A;  2H62 A;  2XV7 A;  2ASK B;  2QR0 O;  1KLC A;  1AGQ B;  2FJG V;  1KLC B;  1AGQ D;  2VPF A;  2VWE A;  3EVS B;  2B0U B;  1QFW B;  2VPF B;  2VWE B;  1AOC A;  3EO1 L;  2VPF F;  2FJH V;  3HH2 A;  3BDY V;  1HD4 A;  1E9J A;  2V5E B;  2VPF D;  3QTK A;  1VPP W;  2QR0 C;  1VPF B;  2GYR A;  3QTK B;  2QR0 I;  2GNN C;  1RV6 W;  1TZH W;  3QTK F;  1CZ8 V;  1TZI V;  3QTK D;  1NYU B;  2QJB A;  2GYR D;  1TFG A;  1FL7 B;  1KAT W;  2ARV A;  1PDG B;  2GH0 D;  1BMP A;  1REW A;  1WQ9 B;  1REW B;  2QR0 J;  1BTG B;  3BK3 B;  2B0U A;  1QFW A;  2P6A B;  1B98 A;  3KFD C;  2BHK A;  1ES7 A;  2X1W C;  2VPF H;  2FJH W;  2GOO A;  2QR0 P;  1VPF A;  1FLT W;  3EO1 C;  1XWD A;  3EO1 I;  2GYR E;  1CZ8 W;  1XWD B;  2ARP A;  2X1X E;  2GOO D;  1BJ1 V;  1VPF D;  2GNN B;  2XAC B;  1LX5 A;  1XWD D;  3B4V A;  2R52 B;  1FL7 A;  1QTY V;  1NYU D;  1AGQ C;  1HRP A;  3B4V B;  3BMP A;  1PDG A;  3B4V F;  2C7W B;  1HRP B;  1KLA B;  1WQ9 A;  1TGJ A;  2TGI A;  1FL7 D;  2R53 B;  2VPF C;  3BK3 A;  2P6A A;  1REU A;  2FJG W;  3MJG B;  2QJA A;  1NT3 A;  2H64 A;  1VPF C;  3QTK C;  1VPP V;  2QJA B;  2VPF E;  1MJV B;  2GYR C;  1S4Y B;  3KFD B;  3FUB B;  1RV6 V;  2QR0 U;  2QR0 V;  2X1W B;  2QJ9 B;  1S4Y D;  3QTK E;  1TGK A;  1HCN B;  2GH0 C;  1SGF Y;  2GNN A;  2VPF G;  2XAC A;  1QTY R;  2R52 A;  1DZ7 A;  1FZV B;  2QR0 D;  2GYZ A;  1QTY W;  1M4U L;  2GNN D;  1WQ8 A;  1BND A;  2C7W A;  1KLA A;  1WAQ A;  1ZKZ A;  1BND B;  2R53 A;  2H62 B;  1KTZ A;  3MJG A;  1ES7 C;  1B8M A;  1NYS B;  1QTY S;  1MJV A;  1AOC B;  1FLT V;  3KFD A;  3HH2 B;  2X1W A;  2QJ9 A;  1TZH V; 
#chains in the KnotProt database with same CATH topology
 2GYR B;  1HCN A;  2QCW A;  2GYR F;  3KFD D;  3FUB D;  2QCW B;  2X1W D;  1FL7 C;  1XWD E;  2PJY A;  2QJB B;  1FZV A;  1BJ1 W;  1PDG C;  1KAT V;  1SGF B;  1LXI A;  2QCQ A;  2ARV B;  3B4V E;  2ASK A;  2QCQ B;  1AGQ A;  2H62 A;  2XV7 A;  2ASK B;  2QR0 O;  1KLC A;  1AGQ B;  2FJG V;  1KLC B;  1AGQ D;  2VPF A;  2VWE A;  3EVS B;  2B0U B;  1QFW B;  2VPF B;  2VWE B;  1AOC A;  3EO1 L;  2VPF F;  2FJH V;  3HH2 A;  3BDY V;  1HD4 A;  1E9J A;  2V5E B;  2VPF D;  3QTK A;  1VPP W;  2QR0 C;  1VPF B;  2GYR A;  3QTK B;  2QR0 I;  2GNN C;  1RV6 W;  1TZH W;  3QTK F;  1CZ8 V;  1TZI V;  3QTK D;  1NYU B;  2QJB A;  2GYR D;  1TFG A;  1FL7 B;  1KAT W;  2ARV A;  1PDG B;  2GH0 D;  1BMP A;  1REW A;  1WQ9 B;  1REW B;  2QR0 J;  1BTG B;  3BK3 B;  2B0U A;  1QFW A;  2P6A B;  1B98 A;  3KFD C;  2BHK A;  1ES7 A;  2X1W C;  2VPF H;  2FJH W;  2GOO A;  2QR0 P;  1VPF A;  1FLT W;  3EO1 C;  1XWD A;  3EO1 I;  2GYR E;  1CZ8 W;  1XWD B;  2ARP A;  2X1X E;  2GOO D;  1BJ1 V;  1VPF D;  2GNN B;  2XAC B;  1LX5 A;  1XWD D;  3B4V A;  2R52 B;  1FL7 A;  1QTY V;  1NYU D;  1AGQ C;  1HRP A;  3B4V B;  3BMP A;  1PDG A;  3B4V F;  2C7W B;  1HRP B;  1KLA B;  1WQ9 A;  1TGJ A;  2TGI A;  1FL7 D;  2R53 B;  2VPF C;  3BK3 A;  2P6A A;  1REU A;  2FJG W;  3MJG B;  2QJA A;  1NT3 A;  2H64 A;  1VPF C;  3QTK C;  1VPP V;  2QJA B;  2VPF E;  1MJV B;  2GYR C;  1S4Y B;  3KFD B;  3FUB B;  1RV6 V;  2QR0 U;  2QR0 V;  2X1W B;  2QJ9 B;  1S4Y D;  3QTK E;  1TGK A;  1HCN B;  2GH0 C;  1SGF Y;  2GNN A;  2VPF G;  2XAC A;  1QTY R;  2R52 A;  1DZ7 A;  1FZV B;  2QR0 D;  2GYZ A;  1QTY W;  1M4U L;  2GNN D;  1WQ8 A;  1BND A;  2C7W A;  1KLA A;  1WAQ A;  1ZKZ A;  1BND B;  2R53 A;  2H62 B;  1KTZ A;  3MJG A;  1ES7 C;  1B8M A;  1NYS B;  1QTY S;  1MJV A;  1AOC B;  1FLT V;  3KFD A;  3HH2 B;  2X1W A;  2QJ9 A;  1TZH V; 
#chains in the KnotProt database with same CATH homology
 2GYR B;  1HCN A;  2QCW A;  2GYR F;  3KFD D;  3FUB D;  2QCW B;  2X1W D;  1FL7 C;  1XWD E;  2PJY A;  2QJB B;  1FZV A;  1BJ1 W;  1PDG C;  1KAT V;  1SGF B;  1LXI A;  2QCQ A;  2ARV B;  3B4V E;  2ASK A;  2QCQ B;  1AGQ A;  2H62 A;  2XV7 A;  2ASK B;  2QR0 O;  1KLC A;  1AGQ B;  2FJG V;  1KLC B;  1AGQ D;  2VPF A;  2VWE A;  3EVS B;  2B0U B;  1QFW B;  2VPF B;  2VWE B;  1AOC A;  3EO1 L;  2VPF F;  2FJH V;  3HH2 A;  3BDY V;  1HD4 A;  1E9J A;  2V5E B;  2VPF D;  3QTK A;  1VPP W;  2QR0 C;  1VPF B;  2GYR A;  3QTK B;  2QR0 I;  2GNN C;  1RV6 W;  1TZH W;  3QTK F;  1CZ8 V;  1TZI V;  3QTK D;  1NYU B;  2QJB A;  2GYR D;  1TFG A;  1FL7 B;  1KAT W;  2ARV A;  1PDG B;  2GH0 D;  1BMP A;  1REW A;  1WQ9 B;  1REW B;  2QR0 J;  1BTG B;  3BK3 B;  2B0U A;  1QFW A;  2P6A B;  1B98 A;  3KFD C;  2BHK A;  1ES7 A;  2X1W C;  2VPF H;  2FJH W;  2GOO A;  2QR0 P;  1VPF A;  1FLT W;  3EO1 C;  1XWD A;  3EO1 I;  2GYR E;  1CZ8 W;  1XWD B;  2ARP A;  2X1X E;  2GOO D;  1BJ1 V;  1VPF D;  2GNN B;  2XAC B;  1LX5 A;  1XWD D;  3B4V A;  2R52 B;  1FL7 A;  1QTY V;  1NYU D;  1AGQ C;  1HRP A;  3B4V B;  3BMP A;  1PDG A;  3B4V F;  2C7W B;  1HRP B;  1KLA B;  1WQ9 A;  1TGJ A;  2TGI A;  1FL7 D;  2R53 B;  2VPF C;  3BK3 A;  2P6A A;  1REU A;  2FJG W;  3MJG B;  2QJA A;  1NT3 A;  2H64 A;  1VPF C;  3QTK C;  1VPP V;  2QJA B;  2VPF E;  1MJV B;  2GYR C;  1S4Y B;  3KFD B;  3FUB B;  1RV6 V;  2QR0 U;  2QR0 V;  2X1W B;  2QJ9 B;  1S4Y D;  3QTK E;  1TGK A;  1HCN B;  2GH0 C;  1SGF Y;  2GNN A;  2VPF G;  2XAC A;  1QTY R;  2R52 A;  1DZ7 A;  1FZV B;  2QR0 D;  2GYZ A;  1QTY W;  1M4U L;  2GNN D;  1WQ8 A;  1BND A;  2C7W A;  1KLA A;  1WAQ A;  1ZKZ A;  1BND B;  2R53 A;  2H62 B;  1KTZ A;  3MJG A;  1ES7 C;  1B8M A;  1NYS B;  1QTY S;  1MJV A;  1AOC B;  1FLT V;  3KFD A;  3HH2 B;  2X1W A;  2QJ9 A;  1TZH V; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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