2CFAB

Structure of viral flavin-dependant thymidylate synthase thyx
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S -31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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-31 68-165 98 1-67 204-215 166-203 67 12 slipknot
Chain Sequence
MSAKLISVTKPVVEGVNTAEELIAYAARVSNPENQINNKTASGLLKYCIRHKHWSIFETAFMTLELKTSRGIAAQVIRHRSFHFQEFS------------------------------PWWATEQEKLYAQSMELYNKALEKGIAKECA-----RFILPLSTPTTIYMSGTIRDWIHYIELRTSNGTQREHIDLANACKEIFIKEFSIAKALDW
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1m 64-131 68 1-3, 155-179 4-63, 132-154 3 25 slipknot
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3.1m 64-154 91 1-3, 156-179 4-63, 155-155 3 24 slipknot
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3.1m 64-155 92 1-3, 158-179 4-63, 156-157 3 22 slipknot
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2.1m 63-157 95 1-3, 169-179 4-62, 158-168 3 11 slipknot
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2.1m 61-168 108 1-12, 170-179 13-60, 169-169 12 10 slipknot
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2.1m 64-157 94 1-62, 169-179 63-63, 158-168 62 11 slipknot
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2.1m 65-153 89 1-63, 168-179 64-64, 154-167 63 12 slipknot
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2.1m 66-154 89 1-64, 162-179 65-65, 155-161 64 18 slipknot
missing residues 89-118, 120-124, 207
publication title Catalytic Mechanism and Structure of Viral Flavin-Dependent Thymidylate Synthase Thyx.
pubmed doi rcsb
structure length 179
molecule tags Transferase
source organism Paramecium bursaria chlorella virus 1
sequence length 215
total genus Genus: 51
molecule keywords THYMIDYLATE SYNTHASE
ec nomenclature ec 2.1.1.148: Thymidylate synthase (FAD).
pdb deposition date 2006-02-17
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF02511 Thy1 Thymidylate synthase complementing protein
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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