2M9PA

Nmr structure of an inhibitor bound dengue ns3 protease
Slipknot S -31 -31 -31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
-31 8-162 155 1-7 222-240 163-221 7 19 slipknot
Chain Sequence
GSAADLELERAADVKWEDQAEISGSSPILSITISEDGSMSIKNEEEEQTLGGGGSGGGGEFAGVLWDVPSPPPVGKAELEDGAYRIKQKGILGYSQIGAGVYKEGTFHTMWHVTRGAVLMHKGKRIEPSWADVKKDLISYGGGWKLEGEWKEGEEVQVLALEPGKNPRAVQTKPGLFKTNAGTIGAVSLDFSPGTSGSPIIDKKGKVVGLYGNGVVTRSGAYVSAIAQTEKSIEDNPEIE
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1m 10-156 147 1-9 171-240 157-170 9 70 slipknot
view details
2.1m 9-186 178 1-8 198-240 187-197 8 43 slipknot
view details
2.1m 9-212 204 1-8 225-240 213-224 8 16 slipknot
sequence length 240
structure length 240
publication title NMR structure of an inhibitor bound dengue NS3 protease provides new insights into the NS2B NS3 ligand interactions
rcsb
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Serine protease subunit NS2B, Serine protease NS3
source organism Dengue virus 2
total genus Genus: 36
ec nomenclature ec 2.1.1.56: mRNA (guanine-N(7)-)-methyltransferase.
ec 2.1.1.57: Methyltransferase cap1.
ec 2.7.7.48: RNA-directed RNA polymerase.
ec 3.4.21.91: Flavivirin.
ec 3.6.1.15: Nucleoside-triphosphate phosphatase.
ec 3.6.4.13: RNA helicase.
pdb deposition date 2013-06-18
KnotProt deposition date 2014-09-25
Image from the rcsb pdb (www.rcsb.org)
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