2Q6HA

Crystal structure analysis of leut complexed with l-leucine, sodium, and clomipramine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 216
Slipknot S +31 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 40-263 224 264-514 1-22 23-39 22 250 slipknot
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41 15-295 281 1-14 349-514 296-348 14 166 slipknot
Chain Sequence
VKREHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPPP--TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHESAGTL
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 14-288 275 1-13 302-512 289-301 13 211 slipknot
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4.1 14-301 288 1-13 309-512 302-308 13 204 slipknot
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4.1 6-314 309 1-5 329-512 315-328 5 184 slipknot
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3.2 17-336 320 1-16 351-512 337-350 16 162 slipknot
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3.2 8-317 310 1-5, 324-512 6-7, 318-323 5 189 slipknot
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4.1 11-328 318 1-4, 335-512 5-10, 329-334 4 178 slipknot
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2.1 25-487 463 1-18, 504-512 19-24, 488-503 18 9 slipknot
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2.1 37-364 328 1-19, 393-512 20-36, 365-392 19 120 slipknot
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2.1 43-408 366 409-512 1-19 20-42 19 103 slipknot
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2.1 37-258 222 1-21, 270-512 22-36, 259-269 21 243 slipknot
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1.1 28-247 220 1-22, 254-512 23-27, 248-253 22 259 slipknot
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2.1 43-362 320 1-26, 400-512 27-42, 363-399 26 113 slipknot
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2.1 35-280 246 1-27, 288-512 28-34, 281-287 27 225 slipknot
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1.1 40-245 206 1-31, 254-512 32-39, 246-253 31 259 slipknot
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1.1 40-253 214 1-32, 256-512 33-39, 254-255 32 257 slipknot
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2.1 44-273 230 1-31, 296-512 32-43, 274-295 31 217 slipknot
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2.1 45-263 219 1-36, 278-512 37-44, 264-277 36 235 slipknot
sequence length 514
structure length 512
publication title Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Transporter
source organism Aquifex aeolicus
missing residues 131-132
total genus Genus: 216
ec nomenclature
pdb deposition date 2007-06-05
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling