2Q72A

Crystal structure analysis of leut complexed with l-leucine, sodium, and imipramine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 214
Slipknot S +31 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 41-265 225 266-513 1-21 22-40 21 247 slipknot
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41 14-294 281 1-13 351-513 295-350 13 163 slipknot
Chain Sequence
KREHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPPP--TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHESAGTL
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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4.1 12-300 289 1-11 307-511 301-306 11 205 slipknot
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3.2 11-306 296 1-10 317-511 307-316 10 195 slipknot
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3.2 6-322 317 1-5 330-511 323-329 5 182 slipknot
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3.2 17-332 316 1-16 348-511 333-347 16 164 slipknot
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2.1 42-355 314 1-17, 402-511 18-41, 356-401 17 110 slipknot
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1.1 25-280 256 1-18, 289-511 19-24, 281-288 18 223 slipknot
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2.1 43-409 367 410-511 1-18 19-42 18 101 slipknot
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2.1 37-254 218 1-20, 274-511 21-36, 255-273 20 238 slipknot
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2.1 27-273 247 1-21, 282-511 22-26, 274-281 21 230 slipknot
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1.1 38-243 206 1-24, 252-511 25-37, 244-251 24 260 slipknot
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1.1 38-251 214 1-25, 256-511 26-37, 252-255 25 256 slipknot
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2.1 30-273 244 1-26, 282-511 27-29, 274-281 26 230 slipknot
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2.1 34-278 245 1-27, 291-511 28-33, 279-290 27 221 slipknot
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1.1 41-245 205 1-37, 256-511 38-40, 246-255 37 256 slipknot
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2.1 45-281 237 1-34, 294-511 35-44, 282-293 34 218 slipknot
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2.1 43-261 219 1-36, 275-511 37-42, 262-274 36 237 slipknot
sequence length 513
structure length 511
publication title Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Transporter
source organism Aquifex aeolicus
missing residues 130-131
total genus Genus: 214
ec nomenclature
pdb deposition date 2007-06-05
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling