2QB4A

Crystal structure analysis of leut complexed with l-leucine, sodium and desipramine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 215
Slipknot S +31 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 39-261 223 262-512 1-20 21-38 20 250 slipknot
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41 13-293 281 1-12 349-512 294-348 12 164 slipknot
Chain Sequence
REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPPP--TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHESAGTL
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 11-288 278 1-10 302-510 289-301 10 209 slipknot
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4.1 11-301 291 1-10 304-510 302-303 10 207 slipknot
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4.1 11-303 293 1-10 308-510 304-307 10 203 slipknot
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3.2 17-336 320 1-16 348-510 337-347 16 163 slipknot
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4.1 12-298 287 1-10, 304-510 11-11, 299-303 10 207 slipknot
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4.1 12-303 292 1-10, 306-510 11-11, 304-305 10 205 slipknot
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1.1 22-280 259 1-15, 289-510 16-21, 281-288 15 222 slipknot
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2.1 29-487 459 1-16, 507-510 17-28, 488-506 16 4 slipknot
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2.1 41-356 316 1-17, 401-510 18-40, 357-400 17 110 slipknot
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2.1 43-410 368 411-510 1-17 18-42 17 99 slipknot
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1.1 34-245 212 1-22, 255-510 23-33, 246-254 22 256 slipknot
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1.1 34-254 221 1-22, 258-510 23-33, 255-257 22 253 slipknot
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2.1 32-282 251 1-25, 291-510 26-31, 283-290 25 220 slipknot
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3.1 34-262 229 1-26, 276-510 27-33, 263-275 26 235 slipknot
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2.1 33-282 250 1-31, 291-510 32-32, 283-290 31 220 slipknot
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1.1 40-275 236 1-30, 292-510 31-39, 276-291 30 219 slipknot
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2.1 41-261 221 1-34, 276-510 35-40, 262-275 34 235 slipknot
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2.1 42-265 224 1-40, 276-510 41-41, 266-275 40 235 slipknot
sequence length 512
structure length 510
publication title Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Transporter
source organism Aquifex aeolicus
missing residues 129-130
total genus Genus: 215
ec nomenclature
pdb deposition date 2007-06-15
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling