2QEIA

Crystal structure analysis of leut complexed with l-alanine, sodium, and clomipramine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 41-265 225 266-513 1-22 23-40 22 247 slipknot
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41 14-294 281 1-13 349-513 295-348 13 165 slipknot
Chain Sequence
KREHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPPP--TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHESAGTL
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 11-289 279 1-10 301-511 290-300 10 211 slipknot
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4.1 13-301 289 1-12 312-511 302-311 12 200 slipknot
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4.1 6-313 308 1-5 332-511 314-331 5 180 slipknot
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3.2 8-315 308 1-5, 321-511 6-7, 316-320 5 191 slipknot
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3.2 19-331 313 1-18 349-511 332-348 18 163 slipknot
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1.1 26-281 256 1-16, 287-511 17-25, 282-286 16 225 slipknot
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2.1 27-486 460 1-17, 503-511 18-26, 487-502 17 9 slipknot
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2.1 42-354 313 1-19, 389-511 20-41, 355-388 19 123 slipknot
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2.1 44-408 365 409-511 1-19 20-43 19 102 slipknot
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2.1 36-256 221 1-20, 269-511 21-35, 257-268 20 243 slipknot
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1.1 41-245 205 1-25, 256-511 26-40, 246-255 25 256 slipknot
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1.1 40-275 236 1-26, 294-511 27-39, 276-293 26 218 slipknot
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3.1 35-268 234 1-29, 272-511 30-34, 269-271 29 240 slipknot
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3.1 38-265 228 1-34, 272-511 35-37, 266-271 34 240 slipknot
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2.1 42-388 347 1-34, 401-511 35-41, 389-400 34 111 slipknot
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2.1 41-270 230 1-35, 277-511 36-40, 271-276 35 235 slipknot
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2.1 44-263 220 1-36, 272-511 37-43, 264-271 36 240 slipknot
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2.1 42-271 230 1-40, 277-511 41-41, 272-276 40 235 slipknot
missing residues 130-131
publication title Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
pubmed doi rcsb
structure length 511
molecule tags Transport protein
source organism Aquifex aeolicus
sequence length 513
total genus Genus: 211
molecule keywords Transporter
ec nomenclature
pdb deposition date 2007-06-25
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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