2XRGA

Crystal structure of autotaxin (enpp2) in complex with the ha155 boronic acid inhibitor
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 115-302 188 1-114 431-803 303-430 114 373 slipknot
Chain Sequence
GSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIKVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDASFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAK------YDPKTIIAALTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPFQGDHG------------FDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPDEVSRPNYPGIMDLGCTCDTEERHLLYGRP------AVLYRTSYDILYH---------------------TDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWAYFQRVLVKKYASERNGVNVISGPIFDYNYDGLRDTEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTY
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 33-301 269 1-32 308-758 302-307 32 451 slipknot
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3.1 115-303 189 1-114 412-758 304-411 114 347 slipknot
view details
3.1 114-411 298 1-113 413-758 412-412 113 346 slipknot
view details
3.1 48-412 365 1-47 416-758 413-415 47 343 slipknot
sequence length 803
structure length 758
publication title Structural Basis of Substrate Discrimination and Integrin Binding by Autotaxin.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMB
source organism Rattus norvegicus
missing residues 341-346, 403-414, 502-507, 515-535
total genus Genus: 196
ec nomenclature ec 3.1.4.39: Alkylglycerophosphoethanolamine phosphodiesterase.
pdb deposition date 2010-09-14
KnotProt deposition date 2014-10-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01033 Somatomedin_B Somatomedin B domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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