3TB3A

Crystal structure of the uch domain of uch-l5 with 6 residues deleted
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 68
Alphaknot: Q9Y5K5
Slipknot S -31 -31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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-31 5-162 158 1-4 213-220 163-212 4 8 slipknot
Chain Sequence
EWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNAAATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFAR----------------AFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSD
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1m 5-161 157 1-4 170-220 162-169 4 51 slipknot
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2.1m 4-169 166 1-3 177-220 170-176 3 44 slipknot
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2.1m 4-177 174 1-3 182-220 178-181 3 39 slipknot
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3.1m 6-182 177 1-5 213-220 183-212 5 8 slipknot
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3.1m 4-212 209 1-3 214-220 213-213 3 7 slipknot
sequence length 220
structure length 204
publication title Length of the active-site crossover loop defines the substrate specificity of ubiquitin C-terminal hydrolases for ubiquitin chains.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Ubiquitin carboxyl-terminal hydrolase isozyme L5
source organism Homo sapiens
missing residues 140-155
total genus Genus: 68
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2011-08-05
KnotProt deposition date 2018-09-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01088 Peptidase_C12 Ubiquitin carboxyl-terminal hydrolase, family 1
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling