3E8DA

Crystal structures of the kinase domain of akt2 in complex with atp-competitive inhibitors
Warning
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 98
Knot K 41 41

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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41 35-322 288 1-34, 323-335 34 13 knot
Chain Sequence
KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI-------------------THFPQFDYSASIR
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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4.1 12-303 292 1-11, 304-316 11 13 knot
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3.2 15-309 295 310-316 1-11 12-14 11 6 slipknot
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3.2 26-305 280 306-316 1-19 20-25 19 10 slipknot
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3.2 34-303 270 304-316 1-23 24-33 23 12 slipknot
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3.2 38-304 267 305-316 1-33 34-37 33 11 slipknot
How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling