3F3CA

Crystal structure of leut bound to 4-fluoro-l-phenylalanine and sodium
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 40-261 222 262-511 1-20 21-39 20 249 slipknot
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41 13-293 281 1-12 350-511 294-349 12 162 slipknot
Chain Sequence
REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPPP--TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHESAGT
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 10-286 277 1-9 301-509 287-300 9 209 slipknot
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3.2 11-298 288 1-10 304-509 299-303 10 206 slipknot
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4.1 11-303 293 1-10 309-509 304-308 10 201 slipknot
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4.1 6-308 303 1-5 317-509 309-316 5 193 slipknot
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3.2 16-333 318 1-15 349-509 334-348 15 161 slipknot
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3.2 10-328 319 1-3, 334-509 4-9, 329-333 3 176 slipknot
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2.1 24-363 340 1-17, 372-509 18-23, 364-371 17 138 slipknot
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1.1 32-253 222 1-18, 267-509 19-31, 254-266 18 243 slipknot
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2.1 30-272 243 1-18, 278-509 19-29, 273-277 18 232 slipknot
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1.1 30-277 248 1-18, 281-509 19-29, 278-280 18 229 slipknot
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2.1 29-475 447 1-18, 488-509 19-28, 476-487 18 22 slipknot
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2.1 41-409 369 410-509 1-19 20-40 19 99 slipknot
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1.1 41-274 234 1-23, 294-509 24-40, 275-293 23 216 slipknot
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1.1 41-293 253 1-24, 295-509 25-40, 294-294 24 215 slipknot
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1.1 33-273 241 1-29, 275-509 30-32, 274-274 29 235 slipknot
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2.1 41-273 233 1-32, 275-509 33-40, 274-274 32 235 slipknot
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1.1 40-243 204 1-28, 252-509 29-39, 244-251 28 258 slipknot
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2.1 40-251 212 1-28, 257-509 29-39, 252-256 28 253 slipknot
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2.1 41-261 221 1-32, 272-509 33-40, 262-271 32 238 slipknot
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2.1 41-394 354 1-33, 402-509 34-40, 395-401 33 108 slipknot
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3.1 41-271 231 1-34, 274-509 35-40, 272-273 34 236 slipknot
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2.1 41-403 363 1-35, 410-509 36-40, 404-409 35 100 slipknot
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2.1 43-262 220 1-40, 267-509 41-42, 263-266 40 243 slipknot
missing residues 129-130
publication title A competitive inhibitor traps LeuT in an open-to-out conformation.
pubmed doi rcsb
structure length 509
molecule tags Transport protein
source organism Aquifex aeolicus
sequence length 511
total genus Genus: 213
molecule keywords Transporter
ec nomenclature
pdb deposition date 2008-10-30
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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