3F3EA

Crystal structure of leut bound to l-leucine (30 mm) and sodium
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 39-264 226 265-511 1-20 21-38 20 246 slipknot
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41 15-293 279 1-14 350-511 294-349 14 162 slipknot
Chain Sequence
REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPPP--TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHESAGT
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 11-290 280 1-10 301-509 291-300 10 209 slipknot
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4.1 13-302 290 1-12 313-509 303-312 12 197 slipknot
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3.2 8-314 307 1-7 320-509 315-319 7 190 slipknot
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4.1 7-323 317 1-6 332-509 324-331 6 178 slipknot
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3.2 10-334 325 1-9 349-509 335-348 9 161 slipknot
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3.2 11-300 290 1-3, 303-509 4-10, 301-302 3 207 slipknot
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3.2 17-334 318 1-10, 343-509 11-16, 335-342 10 167 slipknot
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2.1 25-278 254 1-16, 287-509 17-24, 279-286 16 223 slipknot
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2.1 41-405 365 406-509 1-16 17-40 16 103 slipknot
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3.1 37-257 221 1-18, 273-509 19-36, 258-272 18 237 slipknot
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2.1 29-275 247 1-19, 284-509 20-28, 276-283 19 226 slipknot
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1.1 32-243 212 1-24, 252-509 25-31, 244-251 24 258 slipknot
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2.1 33-282 250 1-25, 292-509 26-32, 283-291 25 218 slipknot
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1.1 40-243 204 1-26, 259-509 27-39, 244-258 26 251 slipknot
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1.1 41-279 239 1-27, 294-509 28-40, 280-293 27 216 slipknot
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1.1 41-271 231 1-28, 280-509 29-40, 272-279 28 230 slipknot
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2.1 42-279 238 1-40, 294-509 41-41, 280-293 40 216 slipknot
missing residues 129-130
publication title A competitive inhibitor traps LeuT in an open-to-out conformation.
pubmed doi rcsb
structure length 509
molecule tags Transport protein
source organism Aquifex aeolicus
sequence length 511
total genus Genus: 215
molecule keywords Transporter
ec nomenclature
pdb deposition date 2008-10-30
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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