3GWUA

Leucine transporter leut in complex with sertraline
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 39-264 226 265-511 1-20 21-38 20 246 slipknot
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41 13-293 281 1-12 349-511 294-348 12 163 slipknot
Chain Sequence
REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPPP--TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHESAGT
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 10-287 278 1-9 301-509 288-300 9 209 slipknot
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4.1 12-296 285 1-11 307-509 297-306 11 203 slipknot
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4.1 12-306 295 1-11 308-509 307-307 11 202 slipknot
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4.1 8-312 305 1-7 318-509 313-317 7 192 slipknot
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4.1 7-326 320 1-6 332-509 327-331 6 178 slipknot
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3.2 14-332 319 1-13 347-509 333-346 13 163 slipknot
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2.1 39-406 368 407-509 1-15 16-38 15 102 slipknot
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2.1 25-357 333 1-17, 376-509 18-24, 358-375 17 134 slipknot
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1.1 26-279 254 1-20, 286-509 21-25, 280-285 20 224 slipknot
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2.1 41-253 213 1-23, 272-509 24-40, 254-271 23 238 slipknot
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1.1 37-242 206 1-25, 249-509 26-36, 243-248 25 261 slipknot
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1.1 37-248 212 1-25, 254-509 26-36, 249-253 25 256 slipknot
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2.1 38-243 206 1-36, 254-509 37-37, 244-253 36 256 slipknot
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2.1 33-271 239 1-28, 275-509 29-32, 272-274 28 235 slipknot
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1.1 40-243 204 1-37, 254-509 38-39, 244-253 37 256 slipknot
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2.1 41-275 235 1-29, 292-509 30-40, 276-291 29 218 slipknot
missing residues 129-130
publication title Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
pubmed doi rcsb
structure length 509
molecule tags Transport protein
source organism Aquifex aeolicus
sequence length 511
total genus Genus: 212
molecule keywords Transporter
ec nomenclature
pdb deposition date 2009-04-01
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling