3GWVA

Leucine transporter leut in complex with r-fluoxetine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 40-264 225 265-506 1-20 21-39 20 241 slipknot
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41 14-293 280 1-13 349-506 294-348 13 158 slipknot
Chain Sequence
REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPPP--TDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYITH------WTVWITRFYIIGLFLFLTFLVFLAERRRNH
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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4.1 8-299 292 1-7 305-498 300-304 7 194 slipknot
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3.2 9-326 318 1-8 336-498 327-335 8 163 slipknot
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3.2 14-332 319 1-13 350-498 333-349 13 149 slipknot
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4.1 11-308 298 1-4, 316-498 5-10, 309-315 4 183 slipknot
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4.1 15-316 302 1-7, 323-498 8-14, 317-322 7 176 slipknot
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2.1 29-255 227 1-15, 268-498 16-28, 256-267 15 231 slipknot
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2.1 24-476 453 1-16, 492-498 17-23, 477-491 16 7 slipknot
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1.1 25-273 249 1-17, 288-498 18-24, 274-287 17 211 slipknot
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2.1 42-406 365 407-498 1-17 18-41 17 91 slipknot
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2.1 42-354 313 1-18, 400-498 19-41, 355-399 18 99 slipknot
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2.1 30-276 247 1-24, 287-498 25-29, 277-286 24 212 slipknot
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1.1 40-244 205 1-25, 256-498 26-39, 245-255 25 243 slipknot
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1.1 35-279 245 1-29, 286-498 30-34, 280-285 29 213 slipknot
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1.1 35-285 251 1-26, 291-498 27-34, 286-290 26 208 slipknot
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2.1 41-261 221 1-33, 275-498 34-40, 262-274 33 224 slipknot
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2.1 41-274 234 1-33, 276-498 34-40, 275-275 33 223 slipknot
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1.1 42-272 231 1-33, 293-498 34-41, 273-292 33 206 slipknot
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1.1 43-273 231 1-41, 293-498 42-42, 274-292 41 206 slipknot
missing residues 129-130, 469-474
publication title Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
pubmed doi rcsb
structure length 498
molecule tags Transport protein
source organism Aquifex aeolicus
sequence length 506
total genus Genus: 206
molecule keywords Transporter
ec nomenclature
pdb deposition date 2009-04-01
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling