3GWWA

Leucine transporter leut in complex with s-fluoxetine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
  • Chain breaks within knot 41 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 202
Slipknot S +31 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 40-263 224 264-506 1-20 21-39 20 242 slipknot
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41 13-293 281 1-12 347-506 294-346 12 160 slipknot
Chain Sequence
REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPP-----PDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERRRNH
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.2 10-284 275 1-9 297-501 285-296 9 205 slipknot
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3.2 10-298 289 1-9 310-501 299-309 9 192 slipknot
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3.2 18-330 313 1-17 346-501 331-345 17 156 slipknot
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3.2 10-319 310 1-2, 326-501 3-9, 320-325 2 176 slipknot
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2.1 29-256 228 1-16, 271-501 17-28, 257-270 16 231 slipknot
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1.1 22-270 249 1-16, 279-501 17-21, 271-278 16 223 slipknot
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U.NKNOWN 41-350 310 1-17, 398-501 18-40, 351-397 17 104 slipknot
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2.1 35-416 382 1-17, 460-501 18-34, 417-459 17 42 slipknot
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2.1 41-403 363 404-501 1-18 19-40 18 97 slipknot
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1.1 29-281 253 1-22, 288-501 23-28, 282-287 22 214 slipknot
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1.1 35-253 219 1-29, 260-501 30-34, 254-259 29 242 slipknot
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2.1 41-268 228 1-30, 289-501 31-40, 269-288 30 213 slipknot
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2.1 41-258 218 1-34, 266-501 35-40, 259-265 34 236 slipknot
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3.1 41-265 225 1-34, 269-501 35-40, 266-268 34 233 slipknot
sequence length 506
structure length 501
publication title Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Transporter
source organism Aquifex aeolicus
missing residues 128-132
total genus Genus: 202
ec nomenclature
pdb deposition date 2009-04-01
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00209 SNF Sodium:neurotransmitter symporter family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling