3MT5A

Crystal structure of the human bk gating apparatus
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 188
Alphaknot: Q12791
Knot K -31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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-31 148-630 483 1-147, 631-714 147 84 knot
Chain Sequence
KHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEY------SRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKDNMDSN---------------------------------------------------------------VKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANDKECILASLNIKSMQFDSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVL----------DSLMSATYFNDNILTLIRTLVTGGALE-----------------------------------ALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAPSQCTKRYVITNPPYEFELVPTDLIFCLMQFD
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1m 78-582 505 1-77, 583-593 77 11 knot
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3.1m 13-555 543 1-12 569-593 556-568 12 25 slipknot
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3.1m 55-520 466 1-23, 542-593 24-54, 521-541 23 52 slipknot
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3.1m 55-541 487 1-23, 544-593 24-54, 542-543 23 50 slipknot
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3.1m 48-573 526 1-23, 583-593 24-47, 574-582 23 11 slipknot
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3.1m 52-573 522 1-47, 583-593 48-51, 574-582 47 11 slipknot
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3.1m 121-518 398 1-33, 545-593 34-120, 519-544 33 49 slipknot
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3.1m 121-544 424 1-33, 551-593 34-120, 545-550 33 43 slipknot
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3.1m 68-573 506 1-51, 583-593 52-67, 574-582 51 11 slipknot
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2.1m 88-553 466 1-38, 566-593 39-87, 554-565 38 28 slipknot
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3.1m 88-565 478 1-38, 568-593 39-87, 566-567 38 26 slipknot
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3.1m 88-567 480 1-38, 569-593 39-87, 568-568 38 25 slipknot
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3.1m 88-568 481 1-38, 571-593 39-87, 569-570 38 23 slipknot
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3.1m 78-573 496 1-67, 583-593 68-77, 574-582 67 11 slipknot
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3.1m 121-571 451 1-86, 587-593 87-120, 572-586 86 7 slipknot
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3.1m 119-586 468 1-86, 589-593 87-118, 587-588 86 5 slipknot
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3.1m 120-553 434 1-88, 569-593 89-119, 554-568 88 25 slipknot
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3.1m 120-568 449 1-88, 570-593 89-119, 569-569 88 24 slipknot
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3.1m 120-569 450 1-88, 571-593 89-119, 570-570 88 23 slipknot
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2.1m 117-508 392 1-94, 519-593 95-116, 509-518 94 75 slipknot
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2.1m 118-509 392 1-116, 519-593 117-117, 510-518 116 75 slipknot
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3.1m 144-553 410 1-121, 573-593 122-143, 554-572 121 21 slipknot
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3.1m 140-573 434 1-121, 587-593 122-139, 574-586 121 7 slipknot
sequence length 714
structure length 593
publication title Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution.
pubmed doi rcsb
molecule tags Membrane protein, transport protein
molecule keywords Potassium large conductance calcium-activated channel, subfa
source organism Homo sapiens
missing residues 229-234, 272-334, 465-474, 492-526, 604-606, 679-682
total genus Genus: 188
ec nomenclature
pdb deposition date 2010-04-30
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02254 TrkA_N TrkA-N domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling